تاثیر تمرین تناوبی همراه با مصرف مکمل ویتامین E بر سطوح پلاسمایی fCK18 و آنزیم های کبدی در مردان دارای کبدچرب غیرالکلی

نوع مقاله : مقاله پژوهشی

نویسندگان
1 گروه تربیت بدنی، واحد اهواز، دانشگاه آزاد اسلامی، اهواز، ایران.
2 گروه تربیت بدنی، واحد اهواز، دانشگاه آزاد اسلامی، اهواز، ایران
چکیده
مقدمه: امروزه شیوع بیماری های متابولیکی مانند کبدچرب غیرالکلی در سراسر دنیا رو به افزایش است. این بیماری که عمدتاً به دلیل سبک زندگی نادرست ایجاد می شود در صورت عدم کنترل به فیبروز و حتی سرطان کبد منجر می شود، لذا کنترل این بیماری در مراحل اولیه آن ضروری است.
هدف از تحقیق حاضر بررسی تأثیر هشت هفته تمرین تناوبی و مصرف مکمل ویتامین E بر سطوح پالسمایی 18fCK و آنزیم های ALT و AST در مردان دارای بیماری کبد چرب غیرالکلی بود.
روش کار: در تحقیق نیمه تجربی حاضر تعداد 40 نفر مرد میانسال دارای کبدچرب غیرالکلی با دامنه سنی 45 تا 60 سال بصورت هدفمند انتخاب و سپس بطور تصادفی به 4 گروه، تمرین تناوبی، ویتامین E، تمرین تناوبی + ویتامین E و گروه کنترل تقسیم شدند. گروه تمرین تناوبی، به مدت هشت هفته و با تواتر سه جلسه در هفته و با شدت 50-75 درصد ضربان قلب ذخیره براساس اصل اضافه بار تدریجی تمرین را انجام دادند. گروه ویتامین E، به صورت روزانه قرص ویتامین E با دوز 400 میلی گرم را مصرف کردند و گروه کنترل در هیچ برنامه تمرینی شرکت نکردند. 48 ساعت قبل و بعد از دوره تمرین در همه گروهها و بصورت همزمان نمونهگیری خونی انجام شد و سطوح پالسمایی 18fCK به روش الایزا و سطوح سرمی آنزیم های
ALT و AST به روش کنتیک آنزیمی اندازه گیری شد. برای مقایسه تغییرات درون گروهی از آزمون t وابسته و جهت مقایسه بین گروهی متغیرها از آزمون تحلیل واریانس یک طرفه (آنوا) استفاده شد. داده ها در سطح معنی داری 0/05 و به کمک نرم افزار -23SPSS تجزیه و تحلیل شدند.
یافته ها: نتایج نشان داد که هشت هفته تمرین تناوبی به تنهایی و همراه با مصرف ویتامین E، منجر به کاهش معنی دار سطوح پالسمایی 18fCK و انزیم های ALT و AST شد ( 0/05 < P)، در حالیکه مصرف ویتامین E به تنهایی تأثیر معنی داری بر سطوح این پروتئین و آنزیمهای کبدی نداشت
(P < 0/05).
نتیجه گیری: با توجه به نتایج پژوهش حاضر توصیه می شود افراد دارای کبد چرب غیرالکلی، جهت بهبود وضعیت خود و کاهش آسیب های کبدی ناشی از این بیماری از تمرینات ورزشی تناوبی همراه با مصرف ویتامین E استفاده نمایند
کلیدواژه‌ها

عنوان مقاله English

The effect of interval training combined with vitamin E supplementation on plasma levels of fCK18 and liver enzymes in men with nonalcoholic fatty liver disease

نویسندگان English

Ayeh Sorkhi 1
Mehdi bostani 2
1 Department of Physical Education, Ahv.C., Islamic Azad University, Ahvaz, Iran.
2 Department of Physical Education, Ahv.C., Islamic Azad University, Ahvaz, Iran.
چکیده English

The prevalence of fatty liver disease is increasing worldwide, thus he purpose of the present study was to investigate the effect of eight weeks of interval training and vitamin E supplementation on plasma fCK18 levels in men with nonalcoholic fatty liver disease. Forty middle-aged men with nonalcoholic fatty liver disease, aged 45 to 60 years, were purposively selected and then randomly divided into 4 groups: interval training, vitamin E, interval training + vitamin E, and control group. The interval training group performed training based on the principle of gradual overload for eight weeks, three sessions per week, at an intensity of 50-75% of heart rate reserve. The vitamin E group consumed 400 mg of vitamin E tablets daily, and the control group did not participate in any training program. Blood samples were taken simultaneously 48 hours before and after the training period in all groups, and plasma fCK18 levels were measured by ELISA protein assay.
Results: The results showed that eight weeks of interval training alone and combined with vitamin E consumption resulted in a significant decrease in plasma fCK18 levels (P < 0.05), while vitamin E consumption alone had no significant effect on the levels of this protein (P < 0.05). Conclusion: According to the results of the present study, it is recommended that people with non-alcoholic fatty liver disease use interval training combined with vitamin E consumption to improve their condition and reduce liver damage caused by this disease.

کلیدواژه‌ها English

NAFLD
interval training
fCK18
vitamin E
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