1- Berne RM, Levy MN, Koeppen BM, Tanton BA. Text book of physiology. 5th edition. Philadephia: Mosby 2004; 97-9. 2- Oscar A. Pain pathway and mechanism of neuropthic pain. University at Buffalo 2007; 30(1): 133-8. 3- Levine D, shrrington S. The In tegrative action of the nervous system Acentennia LappraisaL. JournaL of the Neuro Logica Lscience 2007; 253:1-6. 4- Chiu H, SiLmana A, MacfarLan G, Ray D, Gupta A, Dickens C. Poor sleep and depression are independently associated with a reduced pain threshold. Results of a Population Based Study Pain 2005; 115(3):316-21. 5- Mazilu D, Ionescu R. TOPICAL NONSTEROID ANTI-INFLAMATORY DRUGS-INDICATIONS, EFFICACY AND SAFETY. Romanian Journal of Rheumatology. 2019 Jan 1;28(1). 6- Endress PK. Development and evolution of extreme synorganization in angiosperm flowers and diversity: a comparison of Apocynaceae and Orchidaceae. Annals of Botany. 2016 Apr 1;117(5):749-67. 7- Kargar Jahromi H, Karimi Jashni H, Sameni H, Abedi HA, Kargar Jahromi Z, Khabbaz Kherameh Z. The Effect of Aqueous Extract of Dactylorhiza Maculate Root on the Concentration of Hypothalamic-pituitary-thyroid Axis Hormones in Adult Female Rats. Int J Med Res Health Sci 2016; 5:248-252. 8- Kaya S, Tekin AR. The effect of salep content on the rheological characteristics of a typical ice- cream mix. J Food Eng 2001; 47(1): 59-62. 9- Cozzolino S, Widmer A. Orchid diversity: an evolutionary consequence of deception? Trends Ecol Evol 2005; 20(9): 487-494. 10- Baronelumaga MR, Cozzolino S, Kocyan A. Exine micromorphology of Orchidinae (Orchidoideae, Orchidaceae): phylogenetic constraints or ecological influences? Ann Bot 2006; 98(1): 237-244. 11- Hernandez JA, Thimmaiah A. Meta-analysis of 10 herbs of Iowa for traditional, homeopathic and modern medicinal uses. Int J Complement Alt Med. 2018;11(6):326-32. 12- Pourahmad M, Kargar Jahromi H, Kargar Jahromi Z. Protective Effect of Salep on Liver. Hepat Mon 2015; 15(4): e28137. 13- Tekinsen KK, Guner A. Chemical composition and physiocochemical proprtiies of tubera salep produced from som Prchidacea species. Food Chem 2010; 121(2): 468-471. 14- Farhoosh R, Riazi AR. A compositional study on two current types of salep in Iran and their rheological properties as a function of concentration and temperature. Food Hydrocolloids 2007; 21: 660–666 15- Ahmadianai A, Hosseiny J, Semnanian S, Javan M, Saeedi F, Kamalinajad M. Antinociceptive and anti-inflammatory effects of Elaeagnus angustifolia fruit extract. J Ethanopharmacology 2000; 72(1-2): 287-92. 16- Toker G, Kupeli E, Memisoglu M, Yesilada E. Flavonoids with antinociceptive and anti-inflammatory activities from the leaves of Tilia argentea (silver linden). J Ethanopharmacology 2004. 95(2-3): 393-7. 17- Mehmat O, Yagiz U, Mehmat G. Comparison of the effects of specific and nonspeciefic inhibition of nitric oxide synthase on morphine analgesia, tplerance and dependence in mice. Life Sci 2003; 72:1943-51. 18- Kaur R, Chopra K, Singh D. Role of alpha2 receptors in quercetin-induced behavioral despair in mice. J Med Food 2007. 10: 165-68. 19- Ortega-Alvaro A, Berrocoso E, Rey-Brea R, Leza JC, Mico JA. Comparison of the antinociceptive effects of ibuprofen arginate and ibuprofen in rat models of inflammatory and neuropathic pain. Life Sci 2012; 90(1-2): 13-20. 20- Malmberg AB, Yaksh TL. Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats. J Neurosci 1955; 15(4): 2768-76. 21- Nasri S, Ramezanghorbani A, Kamalinejad M. Analgesic and anti-inflammatory effects of hydroalcoholic extract of Stachys Lavandolifolia Vahl S, aerial parts in male mice. Armaghan Danesh 2011; 16(2): 161-71. 22- Basim A, Hojjati MR, Alibabaei Z, Fathpoor H. Evaluating the analgesic effect of Cucurbita maxima Duch hydro-alcoholic extract in rats. J Shahrekord Univ Med Sci 2014; 16(4): 88-94. 23- Faraji Z, Nikzad H, Parivar K, Nikzad M. The effect of aqueous extract of Salep Tubers on the structure of testis and sexual hormones in male mice. Journal of Jahrom University of Medical Sciences . 2013; 11( 1): 71-76. 24- Harton LR, Richardson JR, Armendariz A, Nazarian A. Dissociation of morphine analgesic effects in the sensory and affective components of formalin-induced spontaneous pain in male and female rats. Brain research. 2017 Mar 1;1658:36-41. 25- Cordova MM, Martins DF, Silva MD, Baggio CH, Carbonero ER, Ruthes AC, Iacomini M, Santos ARS. Polysaccharide glucomannan isolated from Heterodermia obscurata attenuates acute and chronic pain in mice. Carbohydrate Polymers 2013; 92 : 2058– 2064. 26- Pereira MI, Ruthes AC, Carbonero ER, Marcon R, Baggio CH, Freitas CS, et al. Chemical structure and selected biological properties of a glucomannan from the lichenized fungus Heterodermia obscurata. Phytochemistry 2010; 71: 2132–2139. 27- de Souza ET, de Lira DP, de Queiroz AC, da Silva DJ, de Aquino AB, Mella EA, et al. The antinociceptive and antiinflammatory activities of caulerpin, a bisindole alkaloid isolated from seaweeds of the genus Caulerpa. Mar Drugs 2009; 7(4):689-704. 28- Ji RR, Strichartz G. Cell signaling and the genesis of neuropathic pain. Science STKE 2004; 252. 29- Brenner GJ, Ji RR, Shaffer S, Woolf CJ. Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. European Journal of Neuroscience 2004; 20: 375–384. 30- Guo W, Zou S, Guan Y, Ikeda T, Tal M, Dubner R, et al. Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia. Journal of Neuroscience 2002; 22: 6208–6217. 31- Kawasaki Y, Zhang L, Cheng JK, Ji RR. Cytokine mechanisms of central sensitization: Distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. Journal of Neuroscience 2008; 28: 5189–5194. 32- Hoodgar F, Nasri S, Amin Gh. Investigation of Antinociceptive and Anti-inflammatory Effects of Hydroalcoholic Extract of Securigera Securidaca L. Ofogh-e-Danesh, Journal of Gonabad University of Medical Sciences 2011; 17(2): 12-20. 33- Golabi S, hassanpour-ezati M, Rohampour K. Effect of aqueous extracts of sun-dew (Drosera spatulata) on the firing rate of PGi nucleus neurons after formalin-induced pain in rats. Journal of Physiology and Pharmacology 1389. 14 (3): 287-282. 34- علی بابایی زهرا، پیله وریان علی اصغر، شیرانی منوچهر، خیری سلیمان، تاجی فاطمه، عسگری اعظم، رفیعیان محمود. مجله دانشگاه علوم پزشکی شهرکرد، ویژه نامه طب تکمیلی. 1388. ص: 14-9. 35- Lopez LS, Pereira SS, Silva L, Figueiredo kA, Moura BA, Almeida F, Sousa F. Antinociceptive effect ofTopiramate in models of acute pain and diabetic neuropathy in rodents. Life Sciences 2009; 16, 84(3-4): 105-110. 36- دشتی رحمتآبادی محمدحسین، وحیدی مهرجردی علیرضا، پیلهوران علی اصغر، فرزان فاطمه. بررسی اثر عصاره دارچین بر درد مزمن در موش سفید بزرگ آزمایشگاهی با استفاده از آزمون فرمالین. مجله دانشگاه علوم پزشکی و خدمات بهداشتی – درمانی شهید صدوقی یزد، دوره 17، شماره 2. 1388. ص: 199-190. 37- Khalil Z, Liu T, Helwe RD. Free radicals contribute to the reduction in peripheral vascular responses and the maintenance of thermal hyperalgesia in rats with chronic constriction injury. Pain 1999; 79(1):31-37. 38- Picq M, Cheav SL, Prigent AF. Effect of two flavonoid compounds on central nervous system. Analgesic activity. Life Sci 1991; 49(26):1979-88. 39- Juergens UR, Stöber M, Vetter H. Inhibition of cytokine production and arachidonic acid metabolism by eucalyptol (1.8-cineole) in human blood monocytes in vitro. Eur J Med Res 1998. 11:508-10.