لیپوپروتئین با چگالی پایین اکسید شده در سکته قلبی حاد: یک مطالعه مورد-شاهدی

نویسندگان
پیمان ایزدپناه 1
محمد شجاعی 2
زهرا شیبانی 3
امین مصلی نژاد 4
کرامت اله رحمانیان 5
1 استادیار، گروه قلب و عروق،دانشگاه علوم پزشکی شیراز،شیراز،ایران
2 استاد، مرکز تحقیقات بیماری های غیرواگیر، دانشگاه علوم پزشکی، جهرم، ایران
3 متخصص داخلی،دانشگاه علوم پزشکی شیراز،شیراز،ایران
4 بخش مراقبت قلب، بیمارستان پیمانیه،دانشگاه علوم پزشکی جهرم، جهرم،ایران
5 دانشیار، مرکز تحقیقات مولفه های اجتماعی سلامت،دانشگاه علوم پزشکی جهرم، جهرم،ایران
10.52547/jmj.18.1.8
چکیده
مقدمه: متابولیسم بسیاری از چربی ها از جمله اسیدهای چرب آزاد و لیپوپروتئین با چگالی پایین اکسید شده ( Oxidized Low Density Lipoprotein, ox-LDL) نقش مهمی در ایجاد آترواسکلروزیس دارد. هدف از انجام مطالعه حاضر تعیین ارتباط این لیپوپروتئین با سکته قلبی حاد بود.
روش کار: مطالعه مورد- شاهدی روی 43 بیمار مبتلا به سکته قلبی حاد و 43 فرد فاقد نشانه ها و سابقه بیماری قلبی-عروقی یا مغزی-عروقی همسان شده با بیماران از نظر سن و جنسیت انجام شد. از کیت الیزا ساخت شرکت مرکودی، سوئد برای سنجش لیپوپروتئین با چگالی پایین اکسید شده استفاده شد. داده ها به کمک نرم افزار SPSS، نسخه 16 ثبت و سپس تجزیه و تحلیل شدند. سطح معناداری آماری کمتر از 0.05 در نظر گرفته شد.
یافته ها: دو گروه مورد بررسی از نظر سن، جنسیت، استعمال سیگار، سابقه خانوادگی ایسکمی قلبی، هیپرتری گلیسیریدمی، هیپرکلسترولمی، پرفشاری خون، دیابت قندی نوع 2 و وجود بیماری، اختلاف معناداری نداشتند. میانگین غلظت سرمی لیپوپروتئین با چگالی پایین اکسید شده در گروه بیماران و شاهد تفاوت معناداری داشت و میزان آن در گروه مورد (µg/ml 2.14 ± 1.67) بیشتر از گروه شاهد (µg/ml 1.03 ± 1.18) بود ( P=0.001 ). با استفاده از رگرسیون لجستیک چند متغیره و ورود متغیرهای مورد مطالعه در مدل، عامل  LDL اکسید شده به طور مستقلی با خطر بروز سکته قلبی حاد (OR= 1.74, CI95%: 1.2-20.52, p= 0.003) همراه بود.
نتیجه گیری: افزایش  LDL اکسید شده با سکته قلبی حاد ارتباط دارد و ممکن است در تشخیص سکته قلبی کمک کننده باشد.
 
کلیدواژه‌ها
LDL اکسید شده
سکته قلبی
سابقه خانوادگی
سیگاری

عنوان مقاله English

Oxidised LDL in Acute Myocardial Infarction: A Case-Control Study

نویسندگان English

Payman Izadpanah 1
Mohammad Shojaei 2
Zahra Shiebani 3
Amin Mosalanejad 4
Karamatollah Rahmanian 5
1 Assisstant Professor, Deputy of Cardiology, Shiraz University of Medical Sciences, Shiraz, Iran
2 Professor, Research Center for Non Communicable Disease, Jahrom University of Medical Sciences, Jahrom, Iran
3 Internist, Shiraz University of Medical Sciences, Shiraz, Iran
4 Cardiac Care Unit, Peimanieh Hospital, Jahrom University of Medical Sciences, Jahrom, Iran
5 Associate Professor, Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran
چکیده English

Introduction: The metabolism of many fats, including free fatty acids and oxidized low density lipoprotein (ox-LDL)
play an important role in the development of atherosclerosis. The aim of this study was to determine the association between circulating ox-LDL and acute myocardial infarction.
Materials and Methods: The case control study conducted on 43 patients with acute myocardial infarction and 43 volunteers who had no signs, symptoms or history of cardiovascular or cerebrovascular disease and matched to
patients for age and sex (control). We used ELISA kit (company of Mercodia, Sweden) to measure circulating ox-LDL. The data recorded and then analyzed by SPSS software version 16. Statistical significance was considered as p-value less than 0.05.
Results: Two study groups significantly were no differences as age, sex, smoking, family history of ischemic heart disease, hypertriglyceridemia, hypercholesterolemia, hypertension, diabetes mellitus type 2, and disease existence. There was a significant difference between the mean concentration of ox-LDL in AMI and control group as it was higher in the patients (2.14 ± 1.67 μg/ml) than the controls (1.03 ±1.18 μg/ml, p= 0.001). Using logistic regression analysis and entering variables of study in the model, ox-LDL factor was independently associated with the risk of myocardial infarction (OR= 1.74, CI95%: 1.2-20.52, P= 0.003).
Conclusions: Elevated ox-LDL is associated with the acute myocardial infarction and may also be helpful in the early
detection of myocardial infarction.

کلیدواژه‌ها English

Oxidised LDL
Myocardial Infarction
Family History
Smoking
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