1- Coz GM, Gaveriaux-Ruff C, Simonin F. Opioid-induced hyperalgesia: Cellular and molecular mechanisms. Neuroscience. 2016;338:160-82. 2-James MW, Hawkey CJ. Assessment of non-steroidal anti-inflammatory drug (NSAID) damage in the human gastrointestinal tract. British journal of clinical pharmacology. 2003;56(2):146-55. 3-Gonzalez R, Ballester I, Lopez-Posadas R, Suarez MD, Zarzuelo A, Martinez-Augustin O, et al. Effects of flavonoids and other polyphenols on inflammation. Critical reviews in food science and nutrition. 2011;51(4):331-62. 4.- Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta medica. 1991;57(1):1-7. 5. Srinivas L, Shalini VK, Shylaja M. Turmerin: a water soluble antioxidant peptide from turmeric [Curcuma longa]. Archives of biochemistry and biophysics. 1992;292(2):617-23. 6. Pan R, Qiu S, Lu DX, Dong J. Curcumin improves learning and memory ability and its neuroprotective mechanism in mice. Chinese medical journal. 2008;121(9):832-9. 7. Kim DC, Kim SH, Choi BH, Baek NI, Kim D, Kim MJ, et al. Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors. Biological & pharmaceutical bulletin. 2005;28(12):2220-4. 8. Bao W, Li K, Rong S, Yao P, Hao L, Ying C, et al. Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 induction. Journal of ethnopharmacology. 2010;128(2):549-53. 9. Abe Y, Hashimoto S, Horie T. Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacological research : the official journal of the Italian Pharmacological Society. 1999;39(1):41-7. 10. Zhu X, Li Q, Chang R, Yang D, Song Z, Guo Q, et al. Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model. PloS one. 2014;9(3):e91303. 11. Zhu Q, Sun Y, Yun X, Ou Y, Zhang W, Li JX. Antinociceptive effects of curcumin in a rat model of postoperative pain. Scientific reports. 2014;4:4932. 12. Yimam M, Lee YC, Moore B, Jiao P, Hong M, Nam JB, et al. Analgesic and anti-inflammatory effects of UP1304, a botanical composite containing standardized extracts of Curcuma longa and Morus alba. Journal of integrative medicine. 2016;14(1):60-8. 13. Yimam M, Lee YC, Moore B, Jiao P, Hong M, Nam JB, et al. UP1304, a Botanical Composition Containing Two Standardized Extracts of Curcuma longa and Morus alba, Mitigates Pain and Inflammation in Adjuvant-induced Arthritic Rats. Pharmacognosy research. 2016;8(2):112-7. 14. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Alternative medicine review : a journal of clinical therapeutic. 2009;14(2):141-53. 15. Ammon HP, Safayhi H, Mack T, Sabieraj J. Mechanism of antiinflammatory actions of curcumine and boswellic acids. Journal of ethnopharmacology. 1993;38(2-3):113-9. 16. RANJBAR A, RANJBAR M. The anti-inflammatory effects of the Curcuma longa extract in experimental model of inflammation. 2009. 17. Heeba GH, Mahmoud ME, El Hanafy AA. Anti-inflammatory potential of curcumin and quercetin in rats: role of oxidative stress, heme oxygenase-1 and TNF-alpha. Toxicology and industrial health. 2014;30(6):551-60. 18. Kuo ML, Huang TS, Lin JK. Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. Biochimica et biophysica acta. 1996;1317(2):95-100. 19. Weber WM, Hunsaker LA, Abcouwer SF, Deck LM, Vander Jagt DL. Anti-oxidant activities of curcumin and related enones. Bioorganic & medicinal chemistry. 2005;13(11):3811-20. 20. De R, Kundu P, Swarnakar S, Ramamurthy T, Chowdhury A, Nair GB, et al. Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. Antimicrobial agents and chemotherapy. 2009;53(4):1592-7. 21. Lev-Ari S, Maimon Y, Strier L, Kazanov D, Arber N. Down-regulation of prostaglandin E2 by curcumin is correlated with inhibition of cell growth and induction of apoptosis in human colon carcinoma cell lines. Journal of the Society for Integrative Oncology. 2006;4(1):21-6. 22. Ranjbar A. The Analgesic Effect of Solenanthus Circinnatus Root Extract in Male Rat. Journal of Isfahan Medical School. 2010;27(101). 23. Dubuisson D, Dennis SG. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain. 1977;4(2):161-74. 24. D'AMOUR FE, SMITH DL. A method for determining loss of pain sensation. Journal of Pharmacology and Experimental Therapeutics. 1941;72(1):74-9. 25. De Jongh RF, Vissers KC, Meert TF, Booij LH, De Deyne CS, Heylen RJ. The role of interleukin-6 in nociception and pain. Anesthesia and analgesia. 2003;96(4):1096-103, table of contents. 26. Ip WKE, Hoshi N. Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. 2017;356(6337):513-9. 27. Dileep KV, Tintu I, Sadasivan C. Molecular docking studies of curcumin analogs with phospholipase A2. Interdisciplinary sciences, computational life sciences. 2011;3(3):189-97. 28. Calabrese V, Butterfield DA, Stella AM. Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer's disease. The Italian journal of biochemistry. 2003;52(4):177-81. 29. Zhao X, Xu Y, Zhao Q, Chen CR, Liu AM, Huang ZL. Curcumin exerts antinociceptive effects in a mouse model of neuropathic pain: descending monoamine system and opioid receptors are differentially involved. Neuropharmacology. 2012;62(2):843-54. 30. Ji FT, Liang JJ, Liu L, Cao MH, Li F. Curcumin exerts antinociceptive effects by inhibiting the activation of astrocytes in spinal dorsal horn and the intracellular extracellular signal-regulated kinase signaling pathway in rat model of chronic constriction injury. Chinese medical journal. 2013;126(6):1125-31.