1. Siesj BK. Pathophysiology and treatment of focal cerebral ischemia. J Neurosurg 1992; 77(2):169-84. 2. Benchoua A, Guégan C, Couriaud C, et al. Specific caspase pathways are activated in the two stages of cerebral infarction. J Neurosci 2001; 21(18):7127-34. 3. Murakami K, Kondo T, Chan PH. Reperfusion following focal cerebral ischemia alters distribution of neuronal cells with DNA fragmentation in mice. Brain Res 1997; 751(1):160-4. 4. Siesjö BK. Cell damage in the brain: a speculative synthesis. J Cereb Blood Flow Metab 1981; 1(2):155-85. 5. Britton M, Rafols J, Alousi S, et al. The effects of middle cerebral artery occlusion on central nervous system apoptotic events in normal and diabetic rats. Int J Exp Disabil Res 2003; 4(1):13-20. 6. Tatsuki I, Motohiro I, Shozo N, et al. Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury. J Neural Transm 2011; 118(9):1263-72. 7. Ang ET, Gomez-Pinilla F. Potential therapeutic effects of exercise to the brain. Curr Med Chem 2007; 14:2564-2571. 8. Somani SM, Ravi R, Rybak LP. Effect of exercise training on antioxidant system in brain region of rat. Pharmacol Biochem Behav 1995; 50:635-639. 9. Soriano FX, Papadia S. Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability. J Neurosci 2006; 26(17):4509-4518. 10. Liebelt B, Papapetrou P, Ali A. Exercise preconditioning reduces neuronal apoptosis in stroke by upregulating heat shock protein-70 (heat shock protein-72) and extracellular-signal-regulated-kinase 1/2. Neuroscience 2010; 166(4):1091-1100. 11. Ploughman M, Granter-Button S, Chernenko G. Exercise intensity influences the temporal profile of growth factors involved in neuronal plasticity following focal ischemia 2007; 1150:207-216. 12. Goto S, Radak Z. Regular exercise attenuates oxidative stress in aging rat tissues: a possible mechanism toward anti-aging medicine. JESF 2007; 5(1):1-6. 13. Zhang F, Jia J, Wu Y, et al. The effect of treadmill training pre-exercise on glutamate receptor expression in rats after cerebral ischemia. Int Mol Sci 2010; 11(7):2658-2669. 14. Zhang F, Wu Y, Jia J. Exercise preconditioning and brain ischemic tolerance. Neuroscience 2011; 177: 170-176. 15. Sharifi ZN, Abolhassani F, Hassanzadeh G, et al. Neuroprotective treatment with FK506 reduces hippocampal damage and prevents learning and memory deficits after transient global ischemia in rat. Arch Neurosci 2013; 1(1):35-40. 16. Sharifi ZN, Abolhassani F, Zarrindast MR, et al. Effects of FK506 on Hippocampal CA1 Cells Following Transient Global Ischemia/Reperfusion in Wistar Rat. Stroke Res Treat 2012; 2012: 809417; 1-8. 17. Harooni HE, Naghdi N, Sepehri H, et al. The role of hippocampal nitric oxide (NO) on learning and immediate, short-and long-term memory retrieval in inhibitory avoidance task in male adult rats. Behav Brain Res 2009; 201(1):166-172. 18. Popa-Wagner A, Stocker K, Balseanu AT, et al. Effects of granulocyte-colony stimulating factor after stroke in aged rats. Stroke 2010; 41(5):1027-31. 19. Van Meeteren NL, Brakkee JH, Helders PJ, et al. The effect of exercise training on functional recovery after sciatic nerve crush in the rat. J Peripher Nerv Syst 1998; 3(4):277-82. 20. Cotman CW, Berchtold NC. Physical activity and the maintenance of cognition: learning from animal models. Alzheimers Dement 2007; 3(2): 30-37. 21. Burghardt PR, Fulk LJ, Hand GA, et al. The effects of chronic treadmill and wheel running on behavior in rats. Brain Res 2004; 1019:84-96. 22. Ankarcrona M, Dypbukt JM, Bonfoco E, et al. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 1995; 15(4):961-973. 23. Hossmann KA. Glutamate Mediated Injury in Focal Cerebral Ischemia: The Excitotoxin Hypothesis Revised. Brain Pathol 1994; 4(1):23-36. 24. Sugawara T, Fujimura M, Noshita N, et al. Neuronal death/survival signaling pathways in cerebral ischemia. Neuro Rx 2004; 1(1):17-25. 25. Zwagerman N, Plumlee C, Guthikonda M, et al. Toll-like receptor-4 and cytokine cascade in stroke after exercise. Neurol Res 2010; 32(2):123-6. 26. Zwagerman N, Sprague S, Davis MD, et al. Pre-ischemic exercise preserves cerebral blood flow during reperfusion in stroke. Neurol Res 2010; 32(5):523-9. 27. Ness JK, Scaduto RC, Wood TL. IGF-I prevents glutamate-mediated bax translocation and cytochrome C release in O4+ oligodendrocyte progenitors. Glia 2004; 46(2):183–194. 28. Jia J, Feng Z, Yong-Shan H. Treadmill pre-training suppresses the release of glutamate resulting from cerebral ischemia in rats. Exp Brain Res 2010; 204(2):173-179. 29. Jia J, Hu Y-S, Wu Y, et al. Pre-ischemic treadmill training affects glutamate and gamma aminobutyric acid levels in the striatal dialysate of a rat model of cerebral ischemia. Life Sci 2009; 84(15):505-11. 30. Khaksari M, Aboutaleb N, Nasirinezhad F, et al. Apelin-13 protects the brain against ischemic reperfusion injury and cerebral edema in a transient model of focal cerebral ischemia. J Mol Neurosi 2012; 48(1):201-8. 31. Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001; 21(1):2-14. 32. Radak Z, Kumogai S, Taylor AW. Effects of exercise on brain function: role of free radicals. Appl Physiol Nutr Metab 2007; 32(5):942-946. 33. Giffard RG, Yenari MA. Many mechanisms for hsp70 protection from cerebral ischemia. J Neurosurg Anesthesiol 2004; 16(1):53-61. 34. Matsumori Y, Hong SM, Aoyama K, et al. Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury. J Cereb Blood Flow Metab 2005; 25(7):899-910. 35. Kiang JG, Tsokos GC. Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacol Ther 1998; 80(2):183-201. 36. Ohtsuka K, Suzuki T. Roles of molecular chaperones in the nervous system. Brain Res Bull 2000; 53(2):141-146. 37. Starnes JW, Choilawala AM, Taylor RP, et al. Myocardial heat shock protein 70 expression in young and old rats after identical exercise programs. J Gerontol A Biol Sci Med Sci 2005; 60(8):963–969. 38. Botchkina GI, Meistrell M, Botchkina IL, et al. Expression of TNF and TNF receptors (p55 and p75) in the rat brain after focal cerebral ischemia. Mol Med 1997; 3(11):765. 39. Baillat G, Garrouste F, Remacle-Bonnet M, et al. Bcl-xL/Bax ratio is altered by IFNg in TNFα but not in TRAIL-induced apoptosis in colon cancer cell line. Biochim Biophys Acta 2005; 1745(1): 101– 110. 40. Bruce AJ, Boling W, Kindy MS, et al. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 1996; 2(7):788-94. 41. Wang RY, Yang YR, Yu SM. Protective effects of treadmill training on infarction in rats. Brain Res 2001; 922(1):140-3. 42. Reyes JR, Wu Y, Lai Q, et al. Early inflammatory response in rat brain after peripheral thermal injury. Neurosci letters 2006; 407(1):11-5. 43. Cohen-Cory S, Kidane AH, Shirkey NJ, et al. Brain-derived neurotrophic factor and the development of structural neuronal connectivity: Dev Neurobiol 2010; 70(5):271-288. 44. Kim H, Li Q, Hempstead BL, et al. Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brainderived endothelial cells. J Biol Chem 2004; 279(32):33538-33546. 45. Kuipers SD, Bramham CR. Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapy. Curr Opin Drug Discov Devel 2006; 9(5):580-586. 46. Ding Y, Li J, Luan X, et al. Exercise Pre-conditioning Reduces Brain Damage in Ischemic Rats That May be Associated with Regional Angiogenesis and Cellular Overexpression of Neurotrophin. Neuroscience 2004; 124(3):583-591. 47. Ang ET, Wong PT, Moochhala S, et al. Neuroprotection associated with running: is it a result of increased endogenous neurotrophic factors? Neuroscience 2003; 118(2):335-345. 48. Tang KC, Xia FC, Wagner PD, Breen E. Exercise-induced VEGF transcriptional activation in brain, lung and skeletal muscle. Respir Physiol Neurobiol 2010; 170(1):16-22.