تاثیر استازولاماید بر فشار داخل چشم پس از تزریق داخل زجاجیه بواسیزوماب، تریامسینولون استوناید و ترکیب این دو دارو

نوع مقاله : مقاله پژوهشی

نویسندگان
مرکز تحقیقات چشم پزشکی پوستچی، دپارتمان چشم پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران
چکیده
مقدمه: فشار داخل چشمی اغلب به طور گذرا پس از تزریق های داخل چشمی افزایش می یابد که این امر ناشی از افزای ش سریع حجم داخل چشمی است. مطالعه حاضر با هدف بررسی اثر استازولامید خوراکی بر فشار داخل چشم پس از تزریق های داخل زجاجیه چشم طراحی شد.
روش کار: این مطالعه مقطعی-تحلیلی در بیمارستان دستغیب و درمانگاه پوستچی در سال 1402 انجام شد. در این مطالعه از روش نمونه گیری در دسترس استفاده شد. 1073 بیمار 18 تا 82 ساله وارد مطالعه شدند که از این تعداد، 479 بیمار یک ساعت پیش از تزریق داخل چشمی، قرص استازولامید خوراکی دریافت کردند، در حالی که 594 بیمار هیچ دارو یی قبل از تزریق دریافت نکردند.
یافته ها: در مجموع 1073 چشم (از 1073 بیمار) وارد این مطالعه شدند. از این تعداد، 456 نفر ( %42/5) مرد و 617 نفر ( %57/5) زن بودند، با میانگین سنی 38.2 ± 10.8 سال که از 18 تا 82 سال متغیر بود.یافته ها نشان داد که تفاوت معناداری بین دو گروه از نظر سن (0/329=value-p)، جنس (0/6022 =value-p)و نوع داروی تزریقی (0/3898 =value-p )وجود نداشت و بین دو گروه از نظر افزایش فشار چشم بیشتر از 5 میلیمتر جیوه در ماه اول (0/89 =value-p )نسبت به فشار چشم پایه (قبل از تزریق ) و همچنین فشار چشم بالاتر از 25 میلیمتر جیوه در روز اول (0/36 =value-p )و ماه اول (0/92 =value-p )وجود نداشت.
نتیجه گیری: تجویز استازولامید خوراکی پیش از تزریق های داخل چشمی به نظر می رسد مزیت بالینی قابل توجهی در پیشگیری از افزایش موقت یا ماندگار فشار داخل چشمی نداشته باشد. با توجه به اثربخشی محدود، عوارض احتمالی و هزینه اضافی، مصرف روتین این دارو پیش از تزریق های داخل چشمی معمول توصیه نمی شود.
کلیدواژه‌ها

عنوان مقاله English

Effect of Acetazolamide on Intraocular Pressure After Intravitreal Injections of Bevacizumab, Triamcinolone Acetonide and Combination of Bevacizumab - Triamcinolone Acetonide

نویسندگان English

Ehsan Namvar
Mohammadkarim Johari
MohammadHosein Nowrouzzadeh
Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده English

Introduction: Intraocular pressure (IOP) often rises transiently following intravitreal injections as a result of the rapid increase in intraocular volume produced by the injected drug solution. Understanding how to manage this temporary pressure spike is clinically important, particularly for patients with ocular hypertension. The present study was designed with the aim of examining a larger number of patients compared to previous similar studies, in order to more precisely investigate the effect of oral acetazolamide in preventing intraocular pressure increase resulting from intraocular injections.
Methods: This study was a cross-sectional descriptive study conducted in Dastgheib hospital and Poostchi ophthalmology clinic in 2023, which included a total of 1,073 patients aged 18 to 82 years. Of these, 479 patients received an oral acetazolamide tablet one hour prior to the intraocular injection, while 594 patients did not receive any medication before injection.
Results: The analysis revealed that pre-injection administration of oral acetazolamide did not result in a statistically significant or lasting reduction in IOP after intravitreal injection, and its observed effect was minimal and short-term.
Conclusion: Administration of oral acetazolamide before intravitreal injections seem to offer little clinical advantage in preventing transient or sustained IOP increases. Considering its limited efficacy, potential side effects, and additional cost, routine pre-injection use of this medication may not be warranted in standard ophthalmic practice.

کلیدواژه‌ها English

Acetazolamide
increased intraocular pressure
intravitreal injection &‌‌‌‌‌‌‌‌‌‌ndash
bevacizumab
triamcinolone acetonide
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