1. Hall JE. Guyton and Hall textbook of medical
physiology e-Book: Elsevier Health Sciences; 2015.
2. Kuhlmann L, Lehnertz K, Richardson MP, Schelter
B, Zaveri HP. Seizure prediction—ready for a new
era. Nat Rev Neurol. 2018;14(10):618-30.
3. Fisher RS. Animal models of the epilepsies. Brain
Res Rev. 1989;14(3):245-78.
4. Perucca E. The pharmacological treatment of
epilepsy: recent advances and future perspectives.
Acta Epileptologica. 2021;3(1):22.
5. He L-Y, Hu M-B, Li R-L, Zhao R, Fan L-H, He L,
et al. Natural medicines for the treatment of epilepsy:
bioactive components, pharmacology and
mechanism. Front Pharmacol. 2021;12:604040.
6. Gharari Z, Hanachi P, Sadeghinia H, Walker TR.
Eco-Friendly Green Synthesis and Characterization
of Silver Nanoparticles by Scutellaria multicaulis
Leaf Extract and Its Biological Activities.
Pharmaceuticals. 2023;16(7):992.
7. Hussain F, Mittal S, Joshee N, Parajuli P.
Application of Bioactive Compounds from
Scutellaria in Neurologic Disorders. In: Essa MM,
Akbar M, Guillemin G, editors. The Benefits of
Natural Products for Neurodegenerative Diseases.
Cham: Springer International Publishing; 2016. p.
79-94.
8. Parsafar S, Nayeri Z, Aliakbari F, Shahi F,
Mohammadi M, Morshedi D. Multipleneuroprotective features of Scutellaria pinnatifida–
derived small molecule. Heliyon. 2020;6 (8): e04737
9. Yune TY, Lee JY, Cui CM, Kim HC, Oh TH.
Neuroprotective effect of Scutellaria baicalensis on
spinal cord injury in rats. Neurochem.
2009;110(4):1276-87.
10. Monteiro ÁB, Alves AF, Portela ACR, Pires HFO,
de Melo MP, Barbosa NMMV, et al.
Pentylenetetrazole: A review. Neurochem Int.
2024:105841.
11. Hashemi P, Moloudi MR, Vahabzadeh Z,
Izadpanah E. Anticonvulsant Effects of Royal Jelly
in Kainic Acid-Induced Animal Model of Temporal
Lobe Epilepsy Through Antioxidant Activity.
Neurochem Res. 2023 2023/07/01;48(7):2187-95.
12. Yilgor A, Demir C. Determination of oxidative
stress level and some antioxidant activities in
refractory epilepsy patients. Sci Rep.
2024;14(1):6688.
13. Lin T-K, Pai M-S, Yeh K-C, Hung C-F, Wang S-J.
Hydrogen inhalation exerts anti-seizure effects by
preventing oxidative stress and inflammation in the
hippocampus in a rat model of kainic acid-
inducedseizures. Neurochem Int. 2025;183:105925.
14. Rabidas SS, Prakash C, Tyagi J, Suryavanshi J,
Kumar P, Bhattacharya J, et al. A Comprehensive
Review on Anti-Inflammatory Response of
Flavonoids in Experimentally-Induced Epileptic
Seizures. Brain Sci. 2023;13(1):102.
15. Tambun R, Alexander V, Ginting Y, editors.
Performance comparison of maceration method,
soxhletation method, and microwave-assisted
extraction in extracting active compounds from
soursop leaves (Annona muricata): A review .IOP
Conference Series: Materials Science and
Engineering; 2021: IOP Publishing.
16. Taiwe GS, Ndieudieu Kouamou AL, Dabole B,
Ambassa ARM, Mambou HMAY, Bila RB, et al.
Protective Effects of Anthocleista djalonensis
Extracts against Pentylenetetrazole‐Induced Epileptic
Seizures and Neuronal Cell Loss: Role of
Antioxidant Defense System. Evidence‐Based
Complement Altern Med. 2021;2021(1):5523705.
17. Giselvania A, Juniantito V, Wibowo H, Siregar TP,
Gondhowiardjo S. Induction of Hepatocellular
Carcinoma in Conventional Domestic Swine Using
N-Diethylnitrosamine and Phenobarbital. Cancer
Manag Res. 2024:245-57.
18. Buhr P, Kolstrup S, Nikolajsen L-L, Bollen P. The
anaesthetic effects of ketamine/xylazine/midazolam
in C57Bl/6JRj mice. Scand J Lab Anim Sci.
2023;49:21-7.
19. Elsayed AA, Menze ET, Tadros MG, Ibrahim BM,
Sabri NA, Khalifa AE. Effects of genistein on
pentylenetetrazole-induced behavioral and
neurochemical deficits in ovariectomized rats.
Naunyn-Schmiedeberg's Arch Pharmacol.
2018;391(1):27-36.
20. Aldarmaa J, Liu Z, Long J, Mo X, Ma J, Liu J.
Anti-convulsant effect and mechanism of Astragalus
mongholicus extract in vitro and in vivo: protection
against oxidative damage and mitochondrial
dysfunction. Neurochem Res. 2010;35(1):33.
21. Zamani K, Fakhri S, Kiani A, Abbaszadeh F,
Farzaei MH. Rutin engages opioid/benzodiazepine
receptors towards anti-neuropathic potential in a rat
model of chronic constriction injury: relevance to its
antioxidant and anti-inflammatory effects. Naunyn-
Schmiedeberg's Arch Pharmacol. 2025:1-15.
22. Chen Z, Brodie MJ, Ding D, Kwan P. Editorial:
Epidemiology of epilepsy and seizures. Front
Epidemiol. 2023; 3:1273163.
23. Rodideal T, Frunzete ME, Olaru ȘM, Grigore MN,
Zamfirache MM, Ivanescu LC. Comparative analysis
of seed morphology in genus Scutellaria L. Notulae
Botanicae Horti Agrobotanici Cluj-Napoca.
2024;52(3): 14088.
24. Li R, Yan X, Zhao Y, Liu H, Wang J, Yuan Y, et
al. Oxidative Stress Induced by Nuclear Factor
Erythroid 2-Related Factor 2 (NRF2) Dysfunction
Aggravates Chronic Inflammation Through the
NAD+/SIRT3 Axis and Promotes Renal Injury in
Diabetes. Antioxidants. 2025;14(3):267.
25. Tripathi S, Kharkwal G, Mishra R, Singh G.
Nuclear factor erythroid 2-related factor 2 (Nrf2)
signaling in heavy metals-induced oxidative stress.
Heliyon. 2024. 6;10(18):e37545.
26. Zieniuk B, Uğur Ş. The Therapeutic Potential of
Baicalin and Baicalein in Breast Cancer: A
Systematic Review of Mechanisms and Efficacy.
Curr Issues Mol Biol. 2025;47(3):181.
27. Gharari Z, Hanachi P, Walker TR. Green
synthesized Ag-nanoparticles using Scutellaria
multicaulis stem extract and their selective
cytotoxicity against breast cancer. Analytic Biochem.
2022;653:114786.
28. Gathwala G, Marwah A, Gahlaut V, Marwah P.
Effect of high-dose phenobarbital on oxidative stress
in perinatal asphyxia: an open label randomized
controlled trial. Indian Pediatr. 2011;48:613-7.
29. Diaz-Ruiz A, Mendez-Armenta M, Galván-Arzate
S, Manjarrez J, Nava-Ruiz C, Santander I, et al.
Antioxidant, Anticonvulsive and Neuroprotective
Effects of Dapsone and Phenobarbital Against Kainic
Acid-Induced Damage in Rats. Neurochem Res.
2013;38(9):1819-27.
30. Hussain S, Rasul A, Hussain G, Rasheed M, Manan
M, Riaz K, et al. Physiological Significance of
Oxidative Stress and Anti-oxidative System. In:
Imran A, Hussain G, editors. The Role of Natural
Antioxidants in Brain Disorders. Cham: Springer
International Publishing; 2023. p. 49-69.
31. Quinlan S, Khan T, McFall D, Campos-Rodriguez
C, Forcelli PA. Early life phenobarbital exposure
dysregulates the hippocampal transcriptome. Front
Pharmacol. 2024;15:1340691.