مجله علوم پزشکی پارس

تاثیر عصاره هیدروالکلی زنجبیل (zingiber officinale) بر میزان پروفایل لیپیدی موش های صحرایی نر به دنبال دریافت دوکسوروبیسین

نویسندگان

1 دانشجوی دکتری، گروه زیست شناسی، دانشگاه آزاد اسلامی واحد کازرون،کازرون، ایران

2 استادیار، دکتری فیزیولوژی، گروه زیست شناسی، دانشگاه آزاد اسلامی واحد داراب، داراب، ایران

3 دانشیار، گروه زیست شناسی، دانشکده علوم پایه، دانشگاه آزاد اسلامی واحد کازرون، کازرون، ایران

چکیده

مقدمه : دوکسوروبیسین منجر به اختلالات پروفایل لیپیدی می شود. این مطالعه با هدف ارزیابی تاثیر عصاره هیدروالکلی زنجبیل بر وضعیت پروفایل لیپیدی درموش های صحرایی نر به دنبال دریافت دوکسوروبیسن انجام شد.
روش کار:  در این مطالعه تجربی ، 63سر موش صحرایی نر بالغ  به هفت گروه نه تایی تقسیم شدند: گروه کنترل ، گروه شاهد دریافت کننده آب مقطر، گروه تجربی 1 دریافت کننده دوکسوروبیسین به میزان  20 mg/kg/bw   به صورت درون صفاقی و گروه های تجربی 2 و 3 به ترتیب به میزان 300 و 600  mg/kg/bw عصاره هیدروالکلی زنجبیل به صورت دهانی به مدت دو ماه دریافت کردند.  گروه های تجربی 5و 4 به ترتیب مقدار 600 20mg/kg/bw + mg/kg/bw  و 300 20mg/kg/bw+ mg/kg/bw دوکسوروبیسین و عصاره هیدروالکلی زنجبیل به مدت دو ماه دریافت کردند. بعد از پایان دوره آزمایش، نمونه های خونی جمع آوری و میزان سرمی پروفایل های لیپیدی اندازه گیری شد. داده های حاصل به کمک نرم افزار آماری SPSS  نسخه 19 با استفاده از آزمون تحلیل واریانس ها و آزمون تعقیبی توکی با هم مقایسه شدند.
  یافته‌ها : میزان سرمی تری گلیسرید، کلسترول تام ، کلسترول LDL در گروه  دریافت کننده دوکسوروبیسین نسبت به گروه کنترل به طور معناداری افزایش نشان داد، ولی میزان سرمی کلسترول HDL  در گروه  دریافت کننده دوکسوروبیسین نسبت به گروه کنترل به طور معناداری کاهش داشت. مقادیر سرمی تری گلیسرید ، کلسترول تام ، کلسترول LDL و کلسترول HDL در گروه هایmg/kg/bw  600
+ 20mg/kg/bw   و 300 20mg/kg/bw +  mg/kg/bw  نسبت به گروه دوکسوروبیسین کاهش معناداری  نشان داد( P<0.05 ) .
نتیجه گیری:  احتمالا عصاره هیدروالکلی زنجبیل به دلیل داشتن ترکیبات آنتی اکسیدانی باعث بهبود پروفایل لیپیدی پس از دریافت دوکسوروبیسین می شود.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of hydroalcoholic extract of ginger (Zingiber officinale) on the lipid profile of male rats after receiving doxorubicin

نویسندگان [English]

  • Marzieh Niakan 1
  • Habib alla Johary 2
  • Mehrdad Shariati 3

1 Ph.D Student, Department of Biology, Faculty of Sciences, Islamic Azad University, Kazerun Branch, Kazerun, Iran

2 Assistant Professor, Department of Biology, Faculty of Sciences, Islamic Azad University, Darab Branch, Darab, Iran

3 Associated Professor, Department of Biology, Faculty of Sciences, Islamic Azad University, Kazerun Branch, Kazerun, Iran

چکیده [English]

Introduction: Doxorubicin leads to lipid profile disorders. The aim of this study was to evaluate the effect of hydroalcoholic extract of ginger (Zingiber officinale) on the lipid profile of male rats after receiving doxorubicin.
Materials and Methods: In this experimental study, 63 adult male rats were divided into 7 groups of 9: control group, sham group: received distilled water. Experimental group 1 received 20 mg / kg/ bw doxorubicin intraperitoneally, experimental groups 2 and 3 received 300 mg / kg/ bw and 600 mg / kg/ bw of hydroalcoholic extract of ginger orally for 2 months, respectively. Experimental groups 5 and 4 received doxorubicin and hydroalcoholic extract of ginger (20 mg / kg/ bw + 300 mg / kg/ bw) and (20 mg / kg/ bw + 600 mg / kg/ bw), respectively for 2 months. After the end of the experimental period, blood samples were collected and serum levels of lipid profiles were measured. Data were analyzed using SPSS software version 19 and the groups were compared by ANOVA and Tukey test.
Results: Serum levels of triglyceride, total cholesterol, and LDL cholesterol were significantly increased in the doxorubicin group compared to the control group. Serum HDL cholesterol levels in the doxorubicin group showed a significant decrease compared to the control group. Serum levels of triglycerides, total cholesterol, LDL cholesterol and HDL cholesterol in the groups (20 mg / kg/ bw + 300 mg / kg/ bw) and (20 mg / kg/ bw + 600 mg / kg/ bw) showed a significant decrease compared to the doxorubicin group (P<0.05).
Conclusion: Ginger hydroalcoholic extract probably improved its lipid profile after receiving doxorubicin due to its
antioxidant properties.

کلیدواژه‌ها [English]

  • Ginger
  • Doxorubicin
  • Lipid profile
  • Rat
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مجله علوم پزشکی پارس
دوره 20، شماره 1
فروردین 1401
صفحه 22-30