مجله علوم پزشکی پارس

تاثیر تمرین هوازی منظم بر مقادیر فتوئین- A و آدیپونکتین در زنان یائسه مبتلا به دیابت نوع 2 دارای اضافه وزن

نویسندگان

1 دانشیار فیزیولوژی ورزشی، گروه تربیت بدنی، دانشگاه آزاد اسلامی واحد قائمشهر، قائم شهر، ایران

2 کارشناس ارشد فیزیولوژی ورزش، گروه تربیت بدنی،دانشگاه آزاداسلامی واحدساری، ساری، ایران

چکیده

مقدمه: مقدار بالای فتوئین -A و هیپوآدیپونکتینی با اختلال در تنظیم گلوگز و پاتوژنز دیابت نوع دو همراه است. از این رو، هدف از پژوهش حاضر تعیین اثر تمرینات هوازی منظم بر مقادیر پلاسمایی فتوئین- A و آدیپونکتین در زنان یائسه مبتلا به دیابت نوع دو دارای اضافه وزن بود.
روش کار: در این پژوهش نیمه تجربی، ابتدا به صورت در دسترس و هدفمند، 20 زن یائسه مبتلا به دیابت نوع دو انتخاب و سپس به روش تصادفی ساده به گروه های تمرین و کنترل تقسیم شدند (n=10). برنامه تمرینی شامل 25 تا 40 دقیقه تمرین هوازی با شدت 50 تا 70 حداکثر ضربان قلب، سه جلسه در هفته و به مدت هشت هفته بود. مقادیر پلاسمایی فتوئین- A  و آدیپونکتین به روش الایزا و مقدار گلوگز به روش رنگ سنجی آنزیماتیک اندازه گیری شد. داده ها با استفاده از آزمون های t زوجی و  t مستقل در سطح معناداری 0.05˂P با کمک نرم افزار SPSS تحلیل شدند.
یافته ها: بر اساس نتایج پس از 8 هفته تمرین هوازی مقادیر گلوگز ناشتا (0.002=P )،  فتوئین-  A (P =0.001) و وزن بدن(0.001=P) در زنان یائسه مبتلا به دیابت نوع دو کاهش و مقدار آدیپونکتین (0.001>P ) افزایش یافت.
نتیجه گیری: به نظر می رسد فعالیت ورزشی هوازی منظم می تواند برخی از اثرات مطلوب خود را در شرایط پاتولوژیکی دیابت نوع دو  از طریق کاهش مقادیر پلاسمایی فتوئین -A و  تنطیم مثبت آدیپونکتین میانجی گری کند.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of Regular Exercise Training on Fetuin-A and Adiponectin Levels in Postmenopausal Owerweight Women with Type 2 Diabetes Mellitus

نویسندگان [English]

  • Masoumeh Habibian 1
  • Fatemeh Abbaszadeh Talarposhti 2

1 ssociate professor, Department of Physical Education and sport Science, Qaemshahar Branch, Islamic Azad University, Qaemshahar, Iran

2 MSc, Department of Physical Education and sport Science, Sari Branch, Islamic Azad University, Sari, Iran

چکیده [English]

Introduction: Higher levels of fetuin-A and hypoadiponectinemia are associated with impaired glucose regulation and
pathogenesis of type 2 diabetes. The aim of this study was to determine the effect of regular exercise training on Fetuin-A and Adiponectin levels in postmenopausal overweight women with type 2 diabetes mellitus (T2DM).
Materials & Methods: In this semi experimental research, twenty sedentary postmenopausal overweight with T2DM were
selected through convenience sampling and then randomly divided into control and exercise groups (n=10). Training program consisted of 25-40 minutes of aerobic exercise at 50-70 percent of maximal heart rate, 3 sessions per week for 8 weeks. The plasma levels of Fetuin-A and Adiponectin using ELISA method and glucose levels via enzymatic colorimetric method were measured. Data were analyzed by paired and independent t tests. The level of statistical significance was set at P< 0.05.
Results: Based on the results, after 8 weeks of aerobic exercise the levels of fasting glucose (P = 0.002), Fetuin-A (P=0.001) and body weight (P = 0.001) decreased in postmenopausal women with type 2 diabetes and adiponectin levels (P< 0.001) increased.
Conclusion: It seems that regular aerobic exercise can mediate some of its beneficial effects in the pathological
conditions of type 2 diabetes by lowering plasma levels of Fetuin-A and up-regulating adiponectin.

کلیدواژه‌ها [English]

  • Adiponectin
  • Exercise Trainig
  • Fetuin-A
  • type 2 diabetes
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مجله علوم پزشکی پارس
دوره 18، شماره 2 - شماره پیاپی 52
تیر 1399
صفحه 49-56