مجله علوم پزشکی پارس

بررسی فراوانی عفونت هلیکوباکتر پیلوری در افراد مشکوک به گاستریت مزمن مراجعه کننده به کلینیک تخصصی گوارش میلاد شهر سلماس با آزمایش اوره آز تنفسی

نویسندگان

1 وزارت بهداشت درمان وآموزش پزشکی

2 مرکز علم و فنآوری زیست شناسی

چکیده

مقدمه: عفونت هلیکوباکتر پیلوری شیوع بالایی دارد و به طور تقریبی نیمی از جمعیت جهان به این باکتری آلوده هستند. آزمایش تنفسی اوره (UBT) مهمترین آزمایش غیرتهاجمی برای تشخیص هلیکوباکتر پیلوری است. هدف مطالعه حاضر، بررسی میزان فراوانی عفونت هلیکوباکترپیلوری در شهرستان سلماس با روش اوره آز تنفسی بود.
روش کار: مطالعه حاضر روی 80  نفر از مراجعه کنندگان به کلینیک تخصصی گوارش با علایمی همچون تهوع و استفراغ، وجود گاستریت مزمن، سابقه تیتر آنتی بادی IgG مثبت که از طریق پر کردن پرسشنامه و انجام آزمایش اوره آز تنفسی مورد ارزیابی قرار گرفتند، انجام شد. در این مطالعه از آزمون پیرسون، آزمون مربع کای و آزمون تی در  نرم افزار SPSS-21 برای تجزیه و تحلیل داده ها استفاده شد.
یافته­ها: از مجموع 80 نفر، تعداد 37 نفر (46 درصد) دارای عفونت و 43 نفر (54 درصد) فاقد عفونت هلیکوباکتر پیلوری بودند. فراوانی هلیکوباکتر پیلوری در افراد با گروه‌های سنی 50-31 دارای بیش ترین میزان شیوع و افراد کمتر از 20 سال داری کمترین میزان فراوانی نسبت به بقیه گروه های سنی بود. در این مطالعه بین مصرف دخانیات و نیز میزان تحصیلات با فراوانی عفونت در بیماران رابطه معنا‌داری مشاهده نشد.  
نتیجه گیری: با افزایش سطح دانش و آگاهی مرتبط با عوامل دخیل در ایجاد بیماری می‌توان شیوع عفونت هلیکوباکتر پیلوری را کاهش داده و به سطح مطلوب رساند.

کلیدواژه‌ها

عنوان مقاله [English]

Frequency of Helicobacter Pylori Infection in Patients Suspected of Chronic Gastritis Visiting Milad Gastroenterology Clinic of Salmas Using Urea Breath Test

نویسندگان [English]

  • Rasoul Mohammadi 1
  • Babak Barati 1
  • Javid Taghinejad 2
  • Ali Sadeghi 2
  • Mehdi Roshdi Maleki 2
  • Mahtab Gharibnavaz 2

1

2

چکیده [English]

Introduction: Helicobacter pylori infection is highly prevalent and approximately half of the world's population is infected with this bacterium. Urea breath test (UBT) is the most important non-invasive method for diagnosing Helicobacter pylori. This study aimed to evaluate frequency of H. pylori infection in Salmas city, Iran using UBT. Materials and Method: In this case series study, 80 individuals with symptoms of nausea and vomiting, chronic gastritis and a history of positive IgG -confirmed through a checklist- were examined with UBT. Data was analyzed in Spss21 software using Pearson’s, Chi-square and t tests. Results: Of the 80 patients, 37 were infected with H. pylori (46%) and 43 had no infections (54%). The most frequently infected group was aged 51-60 years, while patients younger than 21 years old were the least frequently infected. The frequency of infection had no significant relationship with smoking and education level. Conclusion: Increasing the level of knowledge and health awareness associated with the factors involved in the development of the disease, the prevalence of H. pylori infection can be reduced to a desirable level.  

کلیدواژه‌ها [English]

  • Prevalence
  • Helicobacter pylori
  • Urea Breath Test
  • Salmas
1. Sonnenberg A.Review article: historic changes of Helicobacter pylori-associated diseases. Aliment Pharmacol Ther. 2013; 38(4): 329–42. 2. Amedei A, Munari F, Della Bella C, et al. Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma. Intern Emerg Med. 2014; 9(3):303–9. 3. Nonaka K, Ohata K, Matsuhashi N,et al. Is narrow-band imaging useful for histological evaluation of gastric mucosa-associated lymphoid tissue lymphoma after treatment Dig Endosc. 2014; 26(3):358–64. 4. Suzuki H, Marshall B J, fami Hibi T. Overview: Helicobacter pylori and Extragastric Disease. Int J Hematol. 2006; 84(2): 291-300. 5. Goodwin, C. Helicobacter pylori Biology and Clinical Practice. Boca Raton: CRC Press. 2017. 6. Pizzi M, Saraggi D, Fassan M, et al. Secondary prevention of epidemic gastric cancer in the model of Helicobacter pylori-associated gastritis. Dig Dis. 2014; 32(3):265–74. 7. Thaker Y, Moon A, Afzali A. Helicobacter pylori: A review of Epidemiology, Tretment and Management. J clin Gastroentreol Treat.2016; 2(1):2-5. 8. Guillermo I. Perez-Perez. Dietrich Rothenbacher, et al. Epidemiology of Helicobacter pylori Infection. Black well publishing Ltd, 2004; 9(1):1-6. 9. Hanada K,Graham DY. Helicobacter pylori and the molecular pathogenesis of intestinal-type gastric carcinoma. Expert Rev Anticancer Ther. 2014; 14(8):947–54. 10. Graham DY. History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer. World J Gastroenterol. 2014; 20(18):5191–204. 11. Dominic J. Hare, Hepcidin: a real-time biomarker of iron need, Metalloids, 2017; 9(6):606-618. 12. Zevit N, Balicer RD, Cohen HA, et al. Inverse association between Helicobacter pylori and pediatric asthma in a high-prevalence population. 2012; 17(1):30–35. 13. Nikakhlagh S et al. Determining the Role of Helicobacter pylori in Chronic Sinus Infections Using the Polymerase Chain Reaction. Jundishapur J Microbiol. 2015; 8(3):1-4. 14. Malekzadeh R, Sotoudeh M, Derakhshan M, et al. Prevalence of gastric precancerous lesions in Ardabil, a high incidence province for gastric adenocarcinoma in the northwest of Iran. J clinpathol, 2004; 57)1(: 37-42(Persian). 15. Pantoflickova D, Scott DR, Sachs G, et al. 13C urea breathe test (UBT) in the diagnosis of Helicobacter pylori: why does it work better with acid test meals Gut. 2003; 52(7):933–937. 16. Glynn MK, Friedman CR, Gold BD, et al. Seroincidence of Helicobacter pylori infection in a cohort of rural Bolivian children: acquisition and analysis of possible risk factors. Clinic infect dis, 2002; 35(9):1059-65. 17. Johannes G. Kusters, Amoud H.M. Van Vliet, et al. Pathogenesis of Helicobacter pylori infection. Clinical Microbiology Review, 2006; 4(4):449-490. 18. Karen J. Goodman, Stephaniel.joyce, et al. Ismond. Extrangastric Diseases Associated with Helicobacter Pylori infection. Current Gastroenterology Reports. 2006;8(3):458-464. 19. R. Malekzadeh, M. H. Derakhshan, and Z. Malekzadeh. Gastric cancer in Iran: epidemiology and risk factors, Archives of Iranian Medicine, 2009; 12(6):576-583. 20. Dorji D, Dendup T, Malaty HM, et al. Epidemiology of Helicobacter pylori in Bhutan: the role of environment and Geographic location. 2014; 19(1):69–73. 21. McKeown I, Orr P, MacDonald S et al. Helicobacter pylori in the Canadian arctic: seroprevalence and detection in community water samples. Am J Gastroenterol.1999; 94(22):1823–1829. 22. Santiago P, Moreno Yand Ferrus MA. Identification of Viable Helicobacter pylori in Drinking Water Supplies by Cultural and Molecular Techniques. Health Science Reports. 2015; 20 (4):252-259. 23. Aziz RK, Khalifa MM, Sharaf RR. Contaminated water as a source of Helicobacter pylori infection: A review. Journal of Advanced Research.2015; 6(4): 539-54. 24. Den Hollander WJ, Holster IL, den Hoed CM, et al. Ethnicity is a strong predictor for Helicobacter pylori infection in young women in a multi‐ethnic European city.J Gastroenterol Hepatol.2013; 28(11):1705–11. 25. Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a nationally‐representative, cross‐sectional, screening with the 13C‐Urea breath test. BMC Public Health. 2013; 13(21):4-12. 26. Benajah DA, Lahbabi M, Alaoui S, et al. Prevalence of Helicobacter pylori and its recurrence after successful eradication in a developing nation (Morocco). Clin Res Hepatol Gastroenterol. 2013; 37(5):519–26. 27. Alvarado‐Esquivel C. Seroepidemiology of Helicobacter pylori infection in pregnant women in rural Durango. Mexico Int J Biomed Sci. 2013; 9(4):224–9. 28. Zhu Y, Zhou X, Wu J, et al. Risk factors and prevalence of Helicobacter pylori infection in persistent high incidence area of gastric carcinoma in Yangzhong city. Gastroenterol Res Pract.2014;10(11):1-10 29. Megrand F, Lehours P. Helicobacter pylori detection and antimicrobial susceptibility testing. Clin Microbial Rev. 2007; 20(2):280-322. 30. Ogihara A, Kikuchi S, Hasegawa A, et al. Relationship between Helicobacter pylori infection and smoking and drinking habits. J Gastroenterol Hepatol. 2000; 15(3):271–76. 31. Porras C, Nodora J, Sexton R, et al. Epidemiology of Helicobacter pylori infection in six Latin American countries (SWOG Trial S0701). Cancer Causes Control. 2013; 24(2):209–15. 32. Ghasemi-Kebria F, Ghaemi E, Azadfar S, et al. Epidemiology of Helicobacter pylori infection among Iranian children. Arab J Gastroenterol 2013; 14(9):169–72. 33. Seung-Hyun Ma, Woohyun Jung, Elisabete Weiderpass, et al. Impact of alcohol drinking on gastric cancer development according to Helicobacter pylori infection status. British Journal of Cancer.2015; 113(9): 381–1388. 34. Gao CM, Takezaki T, Ding JH, et al. Protective effect of allium vegetables against both esophageal and stomach cancer: a simultaneous case-referent study of a high-epidemic area in Jiangsu Province, China. Jpn J Cancer Res 1999; 90(6):614–21. 35. Jarosz M, Dzieniszewski J, Dabrowska-Ufniarz E, et al. Effects of high dose vitamin C treatment on Helicobacter pylori infection and total vitamin C concentration in gastric juice. Eur J Cancer Prev 1998; 7(6):449–54. 36. Y Hu, J‐H.Wan, X.‐Y. Li,Y. Zhu, D.Y. Graham, et al. Systematic review with meta‐analysis: the global recurrence rate of Helicobacter pylori, Alimentary Pharmacology & Therapeutics, 2017;47(1):773-779.
مجله علوم پزشکی پارس
دوره 16، شماره 2 - شماره پیاپی 44
تیر 1397
صفحه 35-41