مجله علوم پزشکی پارس

مقایسه اثر 8 هفته تمرین ترکیبی و مصرف مکمل اسید لینولئیک کونژوگه بر سطوح سرمی رزیستین،گلوکز ناشتا، مقاومت به انسولین و عوامل خطرساز قلبی- عروقی زنان چاق

نویسندگان

1 وزارت بهداشت

2 دانشگاه آزاد اسلامی

چکیده

مقدمه:هدف از تحقیق حاضر مقایسه اثر 8هفته تمرین ترکیبی و مصرف مکمل اسید لینولئیک کونژوگه بر سطح سرمی رزیستین،گلوکز ناشتا و مقاومت انسولینی و عوامل خطر ساز قلبی-عروقی زنان چاق بود.
روش کار: 40 زن چاق و اضافه وزن به صورت هدفمند انتخاب و به طورتصادفی به4 گروه تمرین ترکیبی، مکمل ، تمرین ترکیبی و مکمل و کنترل تقسیم شدند. آزمودنی های گروه تمرین و تمرین - مکمل در برنامه تمرین ترکیبی (هوازی-مقاومتی)3روز در هفته با شدت 55 تا 75درصد یک تکرار بیشینه و 55 تا 75حداکثر ضربان قلب بیشینه شرکت کردند.گروه مکمل و تمرین ومکمل روزانه 4 گرم مکمل مکمل اسید لینولئیک کونژوگه و گروه کنترل روزانه 4 گرم دارونما دریافت نمودند.پس از 8 هفته و 48ساعت بعد از آخرین جلسه تمرین ، رزیستین،گلوکز،انسولین ومشخصات آنتروپومتریک مجدداً اندازه گیری شد.داده ها با استفاده  از آزمون t همبسته و از آزمون تحلیل کواریانس  و آزمون تعقیبی بونفرونی در سطح 05/0P≤ با استفاده از نرم افزار آماری SPSS نسخه 22، محاسبه شد.
یافته ها: بعد از هشت هفته تمرینات ترکیبی و مکمل مکمل اسید لینولئیک کونژوگه باعث کاهش سطح سرمی رزیستین ، گلوکزناشتا ،انسولین ومقاومت به انسولین وشاخص های ترکیب بدنی شد 05(/0 P≤). گلوکزناشتا ،انسولین ومقاومت به انسولین وشاخص های ترکیب بدن بین گروهها معنادار بود ( 05/0P≤).
نتیجه گیری:8هفته تمرین ترکیبی و مکمل مکمل اسید لینولئیک کونژوگه با کاهش سطح سرمی رزیستین، گلوکز ناشتا ،مقاومت به انسولین و کنترل وزن، خطر دیابت نوع 2 ،آترواسکلروز و خطر بیماری  قلبی عروقی درزنان چاق کاهش دهد.
 

کلیدواژه‌ها

عنوان مقاله [English]

compare the effect of 8 weeks combined training and conjugated linoleic acids supplementation on serum levels of resistin , Fasting Glucose,insulin resistance and Cardiovascular risk factors obese women

نویسندگان [English]

  • mahnaz sadeghi 1
  • khosro jalali dehkordi 2
  • gholamreza sharifi 1

1

2

چکیده [English]

Introduction:The purpose of this study was to compare the effect of 8 weeks combined training and conjugated linoleic acids supplementationon  on serum levels of resistin , Fasting Glucose,insulin resistance and Cardiovascular risk factors obese women.
Materials and Methods:40 obese women  were selected and randomly divided into 4 groups of combined e training, CLA supplementation, combined training and CLA supplementation and control .combined training program 3 days a week with an intensity of 55-75% of a 1RM, and 55 to 75 maximum heart rate. The supplement and exercise group received daily 4 g CLA supplements and control group received 4 g of placebo daily. After 8 weeks and 48 hours after the last training session, all variables were re-measured. In order to statistical analysis, t-test was used and covariance analysis was used to check the difference between groups. the significance level of the tests was considered to be P≤0.05. All computing was performed by using SPSS software version 22.
Results: After eight weeks of combined training and conjugated linoleic acid supplemented were decreased the serum levels of resistin, glucose, insulin and insulin resistance and body compositin. (P≤0.05). Fasting glucose, insulin and insulin resistance, and body composition indices were significant between groups(P≤0.05).
Conclusion: 8 weeks combination training  and CLA supplementation  with  decrease serum level of  resistin, Fasting Glucose ,insulin resistance and Body composition and control weight decreased The risk of type 2 diabetes, atherosclerosis, and the risk of cardiovascular disease in obese women.
 

کلیدواژه‌ها [English]

  • Combined training and CLA supplements
  • Resistin
  • Insulin resistance
  • body composition indices
1.Haghjoo M, Abdossaleh Z, Hoseini SA. Effect of 8-week Zumba training on overweight women’s body composition. Pars Journal of Medical Sciences 2016;14(2):21-30. 2.Karamatollah R, Mohammad S. Relationship of pre-diabetes and diabetes mellitus with cardiovascular risk factors: A Case-Control studyPars Journal of Medical Sciences2017;15(4):1-8.3. James J. Exercise predicts long-term weight loss in women with class 1 and class 2 obesity through effects on emotional eating and its correlates. Journal of Physical Activity&Helth2018;15(1):57-63. 4 .Bruun JM, Stallknecht B, Helge JW, Richelsen B. Interleukin-18 in plasma and dipose tissue: effects of obesity, insulin resistance and weight loss. Eur J Endocrinol, 2007;157(4): 465-71. 5-Haghighi A,Shojaee M,Hedayati M,Yarahmadi H.Effect of arobic training on adiponectin,resisrin serum and antropometric index Obesity Women.Olampic Journal2013;21(1):1-10. 6- Rahmani Gobadi M, Rahmaninia F, Mirzaei1 B, Hedayati M .Effects of 8 weeks of aerobic training on Agouti-related peptide, appetite hormones and insulin resistance in overweight sedentary women. Pars Journal of Medical Sciences2016:14(2):1-8. 7. Cebeci E,Cengiz C,Meltem G, Serhat K.The Main Determinants of Serum Resistin Level in Type 2 Diabetic Patients are Renal Function and Inflammation not Presence of Microvascular Complication, Obesity and Insulin Resistance.Experimental and Clinical Endocrinology & Diabetes2018;3(14);1-12. 8. Tajmanesh M, Aryaeian N, Hosseini M, Mazaheri R, Kordi R. Evaluation of the effect of conjugated linoleic acids supplementation onblood pressure and body composition of 20-27 year old males: A doubleblind,placebo-controlled clinical trial2013;20(116):46-55. 9.Bulut S, Bodur E , Turnagol H. Effects of conjugated linoleic acidsupplementation and exercise on post-heparin lipoprotein lipase, butyrylcholinesterase, blood lipid profile and glucose metabolism in young men.2013; 203(1):323-329. 10. Lehnen E, Ramos da Silva M, Camach, Aline A, Machado Lehnen. A. A review on effects of conjugated linoleicfatty acid (CLA) upon body compositionand energetic metabolism ournal of the International Society of Sports Nutrition2015;14(2):3-11. 11. Kreider, R. B, Ferreira, M. P, Greenwood, M, Wilson, M, and Almada, A. L. Effects of conjugated linoleic acid supplementatio during resistance training on body composition, bone density, strength, and selectedhematological markers. J. Strength Cond. Res2002; 16: 325–334. 12. Pinkoski, C, Chilibeck, P.D, Candow, D.G, Esliger, D, Ewaschuk, J.B,Farthing, M, Jonathan, P, Zella, G. . The effects of conju-gated linoleic acidsupplementation during resistance training2. Med Sci SportsExerc.2006 . 38(2): 339-348. 13. Botero JP. Shiguemoto GE, Presets J, Marin CT, Do Prado WL, Pontes CS, et al. ffects of Long-term periodized resistance training on body composition, leptin, resistin and muscle Strength in elderly post-menopausal women. J sport Med Phys Fitness2013; 53(3):289-94. 14.Kashef M,Azad A,Khalilzade M.Effect of concurrent conjugated linoleic acid and resistane training on body composition ,leptine and strength muscle femal non athletic2014;7(1)123-139. 15. Jamali E, Asad MR, Rassouli A.Effect of eight-week endurance exercise on resistin gene expression in visceral adipose tissues in obese rats 2016;25(1):20-31. 16. Giannopoulou I, Fernhall B, Carhart R, Weinstock R, Baynard T, Figueroa A, et al. Effects of diet and/or exercise onthe adipocytokine and inflammatory cytokine levels of postmenopausal women with type 2 diabetes. Metabolism 2005;54(7):866-75. 17.Monzillo LU, Hamdy O, Horton ES, Ledbury S, Mullooly C, Jarema C, et al. Effect of lifestyle modification on adipokine in obese subjects with insulin resistance. Obes Res 2003; 11:1048-1054 18-Qi Q, Wang J, Li H, Yu Z, Ye X, Hu FB, et al. Associations of resistin with inflammatory and fibrinolytic markers,insulin resistance, and metabolic syndrome in middle-aged and older Chinese. Eur J Endocrinol 2008; 159:585-593. 19-Belury M.A, Mahon A, Banni S. The Conjugated LinoleicAcid (CLA) isomer, t10c12-CLA, is inversely associated with changes inbody weight and serum leptin in subjects with type 2 diabetes mellitus. J Nutr2003; 133(1):257-60. 20-Gaullier J.H, Hoye K, Kristiansen K, Fagertun H, Vik H. Supplementation with conjugated linoleic acid for 24 months is welltolerated by and reduces body fat mass in healthy, overweight humans". J Nutr.2005; 135(4): 778-84 21.Hamedinia M,Haghighi A.Efecte of arobic training on insulin resistanc and adiponectine serum in female obesity.Olampic208;13(4). 22. Domınguez CS . Inverse association between serum resistin and insulin resistance in humans: Diabetes Res Clin Pract.2008; 82: 256-261 23- Ross R, Janssen I, Dawson J, Kungl AM, Kuk JL, Wong SL, et al. Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. Obesity 2004; 12(5): 789–9 24.Tofighi A,Samadian Z,Mehdizade E,Zolfaghari M.Responc resisrine serum to priod arobic training and correlation with metabolic index in Type 2 diabetic. Tabriz University of Medical Sciences2013;;(18):25-36. 25. Syvertsen C , Hakse J , Hoivik HO , Gaullier JM , Nurminiemi M , With conjugated Lino leic acid on insulin resistance in Overweight and obese . Int J obes (Lond),2007; 31 : 1148-54. 26. Michishita T, Kobayashi S, Katsuya T, ogihara T, kawabuchi k. Evaluation of the antiobesity effects of an amino acid mixture and conjugated linoleic acid on exercising healthy over weight Human an: a randomize, double-blind, placebo – controlled trial. J Int Med Res2012; 38:844-59 27.Tajmanesh M,Arianian N,Hoseyni M,Maaheri R,Kordi R.Effect of conjugated Lino leic acid supplemention on blood peressure and body composition femal young 20-27 yers old. Razi University of Medical Sciences 2013;20(116): 28-Busiello RA , Savarese S,Lombardi A . Mitochod rial uncou Pling proteins and energy etabolism . front physiol 2015; 6 ( 36):12-24.
مجله علوم پزشکی پارس
دوره 16، شماره 2 - شماره پیاپی 44
تیر 1397
صفحه 16-26