Effect of liver function on immunity to hepatitis-B virus in vaccinated patients undergoing hemodialysis, Jahrom-Iran 2025

Document Type : Original Article

Authors
Masihollah Shakeri 1
Forough Sadeghi 2
Sara Rahmanian 1
Heshmatollah Shakeri 3
Karamatollah Rahmanian 4
Vahid Rahmanian 5
Fatemeh Sotoodeh Jahromi 6
AbdolReza Sotoodeh Jahromi 7
1 Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences
2 Student Research Committee, Jahrom University of medical sciences
3 Zoonoses Research Center. Jahrom University of Medical Sciences, Jahrom, Iran
4 Research Center for Social determinants of health, Jahrom University of medical sciences
5 Department of Public Health, Torbat Jam Faculty of Medical Sciences
6 Student Research Committee, Shiraz University of medical sciences
7 Jahrom University of Medical Sciences.
10.22034/pjms.2026.2088772.1282
Abstract
Background: Dialysis patients are at high risk of hepatitis B virus (HBV) infection due to shared dialysis machines. This study aimed to determine the association of immunity to HBV with serum levels of liver function markers in dialysis patients vaccinated against HBV.
Methods: This cross-sectional-analytical study was conducted on 64 dialysis patients in Jahrom-Iran, 2025. Demographic information, serum levels of antibodies against HBV, and liver function indexes were extracted from the patients' records. After collection, the data were analyzed using SPSS-16 software and descriptive and analytical statistics.
Results: Of the 64 dialysis patients studied, 59.4% were male. 87.50% of patients were immune to HBV. There was no significant difference in terms of age, gender, and HBV immunity status (P >0.05). The mean serum levels of transferases, alkaline phosphatase, and bilirubin were statistically significantly different in immune and non-immune patients (P <0.05).
Conclusion: The immunity rate to HBV in the studied patients is satisfactory compared to the results of other studies. This immunity has a significant inverse relationship with the serum levels of transferases, alkaline phosphatase and bilirubin. It is recommended to conduct detailed studies with a larger sample size to investigate the role of these factors and liver diseases on immunity to HBV in dialysis patients.
Keywords
Hepatitis B immunity
bilirubin
alkaline phosphatase
transferase
dialysis