The effect of a period of resistance training along with the consumption of sumac supplement on Bcl-2 and Bax variables in Alzheimer's rats

Document Type : Original Article

Authors
Akbar Yegane Hashemi 1
Abbas Saremi 2
Mohammad Reza Afarinesh 3
1 Department of Physical Education, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2 Professor of Sports Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran
3 Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
10.22034/pjms.2024.2038683.1156
Abstract
Introduction: Bcl-2 and Bax are factors affecting the occurrence of Alzheimer's disease in the elderly.The aim of this study was to investigate the effect of a period of resistance training along with sumac supplementation on Bcl-2 and Bax variables in Alzheimer's rats.
Materials and Methods: In this experimental study, 35 rats were randomly divided into five control groups, Alzheimer's disease, Alzheimer's disease with sumac supplement, Alzheimer's disease with resistance training, and Alzheimer's disease with resistance training and sumac supplement consumption. Then, an amount of 8 mg/kg of trimethyltin chloride was injected into mice to induce Alzheimer's disease. Resistance exercises were performed for 12 weeks and blood samples were taken. The variables were analyzed by ELISA method. One-way ANOVA with Tukey's post hoc test at a significance level of 0.05 was used to analyze the data.
Results: The findings showed that a period of resistance training along with receiving sumac supplement, as well as receiving sumac alone caused a significant decrease in Bax protein expression (p<0.001) and an increase in Bcl-2 protein expression (p<0.001) in all researched groups (p<0.05).
Conclusion: The resistance training program along with the consumption of sumac supplement can reduce the expression of Bax protein and increase the expression of Bcl-2 protein in all research groups. This increase can probably reduce the progression of Alzheimer's disease or slow down its process.
Keywords
Alzheimer's Disease
Resistance Training
Sumac Supplement
Bcl-2
Bax
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