Comparison of ketamine and dexmedetomidine in maintaining hemodynamic stability in laparoscopic cholecystectomy surgery with general anesthesia : a double-blind randomized clinical trial study
Document Type : Original Article
Authors
1 Department of Surgery, Jahrom University of Medical Sciences, Jahrom, Iran.
2 Associate Professor, Anesthesia Department, Anesthesia and Pain Control Research Center, Jahrom University of Medical Sciences, Jahrom, Iran
3 Department of Surgery, Jahrom University of Medical Sciences, Jahrom, Iran
4 Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran
Abstract
Introduction: One of the basic features of a successful anesthesia is reversible loss of consciousness with immobility, lack of awareness, not responding to painful stimulation and not remembering surgical interventions. The present study was conducted with the aim of comparing ketamine and dexmedetomidine in maintaining hemodynamic stability in laparoscopic head cystectomy surgery with general anesthesia.
Materials and Methods: This study is a double-blind randomized clinical trial Study. 90 patients aged 18 to 44 (in three groups of 30) were evaluated during general anesthesia. Inclusion criteria included anesthesia class (ASA I, II) and consent to participate in the study. Patients were randomly divided into three groups: 1) control and 2) intervention with ketamine, intervention and 3) intervention with dexmedetomidine. Patients' hemodynamic symptoms (systolic blood pressure, diastolic blood pressure, mean arterial pressure, blood oxygen saturation percentage and heart rate) were evaluated. Data analysis was done using descriptive statistics (mean, percentage and standard deviation) and inferential statistical tests (Mann-Whitney and Kruskal-Wallis) using SPSS version 21 software.
Results: The findings of the research showed that between the three groups of ketamine, dexmedetomidine and control in the times before induction, after induction, 5 minutes after, 15 minutes after, 30 minutes after, 60 minutes after, in recovery and outside of recovery, from There was a significant difference in mean systolic and diastolic blood pressure and mean arterial blood pressure (P<0.05). But there was no significant difference in heart rate between the three groups at these times (P<0.05). The average percentage of blood oxygen saturation in the ketamine group was lower than the dexmedetomidine and control groups (P<0.05).
Conclusion: Based on the results of the present study, the use of dexmedetomidine in laparoscopic cholecystectomy surgery compared to ketamine causes hemodynamic stability in laparoscopic cholecystectomy surgery with general anesthesia.
Keywords
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