Evaluation of renal, hepatic, cardiac and hematological diagnostic factors in patients with asthma


1 Instructor, Department of Nursing, Abadan University of Medical Sciences, Abadan, Iran

2 Medical student, Student Research Committee of Abadan University of Medical Sciences, Abadan, Iran

3 Assistant Professor, Department of Infectious Diseases, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran

4 Assistant Professor of Biostatistics, Department of Public Health, School of Health, Abadan University of Medical Sciences

5 Instructor, Department of Epidemiology, Asadabad School of Medical Sciences, Asadabad, Iran

6 Clinical Research Development Unit of Taleghani Educational Hospital, Abadan University of Medical Sciences, Abadan, Iran

7 Instructor, Department of Health Information Technology, Abadan University of Medical Sciences, Abadan, Iran

8 Assistant Professor, Department of Physiology, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran


Introduction: Asthma is the most common chronic respiratory disease and is a major cause of disability and has high
economic costs. Therefore, the aim of this study was to evaluate laboratory diagnostic factors in patients with asthma.
Materials and Methods: The present study is a cross-sectional analytical study that by referring to the medical records
department in the educational hospitals of Abadan University of Medical Sciences, information about age, sex, and laboratory diagnostic factors of patients with asthma admitted from March 21, 2019, to March 19, 2020 was received.
Results: The results of this study showed that the statistical population of patients with asthma included 636 of
which 344 (54.1%) were female and 292 (45.9%) were male and this difference was significant. Mean biochemical markers including blood sugar, triglycerides, liver markers such as SGOT, total and direct bilirubin, hematological factors such as mean ESR and INR were higher than normal and cardiac marker CK was lower than normal.
Conclusions: The results of this study showed that in patients with hospitalized asthma, liver disorders (more in women than men), hyperbilirubinemia, hyperglycemia, hyperlipidemia and impaired cardiac marker, coagulation and inflammation are observed. As a result, more research and timely treatment should be done to prevent further complications of the disease.


1. Fazlollahi MR, Najmi M, Fallahnezhad M, Sabetkish N, Kazemnejad A, Bidad k, etal. The prevalence of asthma in Iranian adults: The first national survey and the most recent updates.The Clinical Respiratory Journal 2016; 12(5): 1872-1881. [Farsi] 2. Shariat M, Rostamian E, Moayeri H, Shariat M, Sharifi L. A review on the relation between obesity and vitamin D with pediatric asthma, and a report of a pilot study in Tehran, Iran: review article. Tehran Univ Med J 2020; 78(5): 274-83. [Farsi] 3. Nanda A, Wasan AN. Asthma in Adults. Med Clin N Am 2019; https://doi.org/10.1016/j.mcna.2019.08.013. 4. Tafti MG, Abdollahi N, Shajari A, Modersi V. The Association between Obesity and Severityof Asthma in Children. J TOLOO E BEHDASHT 2019; 17(6):12-20. [Farsi] 5. Wu TD, Brigham EP, McCormack MC, Asthma in the Primary Care Setting. Med Clin North Am 2019 May; 103(3): 435–452. 6. Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, et al. Inflammatory and comorbid eatures of patients with severe asthma and frequent exacerbation. American journal respiratory and critical care medicine 2017; 195(3):302-13. 7. Price D, Wilson AM, Chisholm A, Rigazio A, Burden A, Thomas M, et al. Predicting frequent asthma exacerbations using blood eosinophil count and other patient data routinely available in clinical practice. Journal of asthma and allergy 2016; 9:1. 8. Chun-YLI, Steven R, Erickson, Chung-Hsuen WU. Metformin use and asthma outcomes among pationts with concurrent asthma and diabetes. Respirology (2016); 21: 1210–1218. 9. Rogala B, Bozek A, Gluck J. Is there a relationship between asthma and diabetes? Journal of Asthma 2019; DOI: 10.1080/02770903.2019.1652642. 10. Roh JH, Lee H, Bae YJ, Park CS, Kim HJ, Yoon SY. Association between Nonalcoholic Fatty Liver Disease and the Incidence of Asthma in Adults: Finding from a Nationwide Study in Korea. Research Square 2021; DOI: https://doi.org/10.21203/rs.3.rs-579281/v1. 11. Wang W, Ji HL. Epithelial Sodium and Chloride Channels and Asthma. Chin Med J 2015; 128(16).2242-9. 12. Kuzniewicz MW, Niki H, Walsh EM, McCulloch CE, Newman TB. Hyperbilirubinemia, Phototherapy and Childhood Asthma. Pediatrics 2018; 142(4): e20180662. 13. Gillissen A, Paparoupa M. Inflammation and infections in asthma. Clin Respir J 2015; 9: 257–269. 14. Amundson D, Seda G, Daheshia M. Recognizing Asthma Mimics and Asthma Complications. MILITARY MEDICINE 2011; 176(10):1162. 15. Kabeya Y, Kato K, Tomita M, Katsuki T, Oikawa Y, Association of Glycemic Status With Impaired Lung Function Among Recipients of a Health Screening Program: A Cross-Sectional Study in Japenese Adults. J Epidemiol 2014; 24(5):410-416. 16. Wu TD, Brigham EP, Keet CA, Brown TT, Hansel NN, McCormack MC. Association Between Pre-Diabetes/Diabetes and Asthma Exacerbations in a Claims-Based Obese Asthma Cohort. J Allergy Clin Immunol Pract 2019; 7(6): 1868–1873. 17. Jiang T, Dai L, Li P, Zhao J, Wang X, An L and etal. Lipid metabolism and identification of biomarkers in asthma by lipidomic analysis. BBA - Molecular and Cell Biology of Lipid 2020; https://doi.org/10.1016/j.bbalip.2020.158853. 18. Sim S, Choi Y, Park HS. Potential Metabolic Biomarkers in Adult Asthmatics.Metabtes 2021; 11(430). 1-29. 19. Das RR, Naik SS. Neonatal hyperbilirubinemia and childhood allergic diseases: a systematic review. Pediatr Allergy Immunol 2015; 26(1):2-11. 20. Elliot JG, Noble PB, Mauad T, Bai TR, Abramson MJ, McKay KO. Inflammation-dependent and independent airway remodelling in asthma. Respirology 2018; 23(12): 1138-1145. 21. Rasyid SA, Armayani, Yuniati, Lio TMP, Analysis of serum glutamic pyruvic transaminase and serum glutamic oxaloacetic transaminas levels in tuberculosis pationts who are undergoing oat treatment in Kendari City General Hospital, Kota Kendari, Indonesia. Infectious Disease Reports 2020; 12(1): 75-77.