Polyamine transporter ATP13A2 and Covid-19: a microarray assay-based and functional analysis study

Authors
Mohsen Alipour 1
Abazar Roustazadeh 2
1 Department of Biochemistry, Department of Advanced Medical Sciences and Technologies, Jahrom University of Medical Sciences, Jahrom, Iran
2 Department of Biochemistry, Department of Advanced Medical Sciences and Technologies, Research Center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran
10.22034/pjms.2022.700479
Abstract
Introduction: Unfortunately, a lot of people infected with and died due to covid-19. The exact mechanism of causative
virus in human body is unknown. The aims of the study were to survey and analysis the microarray data and to perform functional analysis to unveil the new mechanisms of this virus in regarding to human cells.
Materials and Methods: NCBI microarray extracted data were analyzed by GEO2R and R package. Up- and down regulated genes were extracted and functional analysis was performed.
Results: Results showed that in Log2 expression greater than 3 and lesser than -3 of transcriptome, there were 319 and 573 up-regulated genes in mild and severe covid-19 patients, respectively. Also there were 156 and 590 down-regulated genes in mild and severe covid-19 patients, respectively. GO analysis showed that deferentially expressed gene pattern in severe covid-19 patients is related to ATP13A2.
Conclusion: Covid-19 probably regulates its vitality in human cells through interplay with factors such as ATP13A2.
Keywords
Covid-19
Microarray
ATP13A2
Functional Analysis
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