Cytomegalovirus Infection in Renal Recipients in Al_Zahra Hospital of Isfahan
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Abstract
Introduction: Renal transplant patients who receive immunosuppressive drugs are prone to opportunistic infections such as CMV. CMV activity occurs in patients who have IgG anti CMV , causing severe morbidity, with high mortality and transplant rejection.
This study was conducted to detect the prevalence of anti CMV (IgM, IgG) before transplantation and long term follow up of active CMV disease incidence.
Methods: In this descriptive analytic study, all of the 70 patients who were candidates for renal transplantation during 1381-1384 were studied in Al_Zahra Hospital of Isfahan .After blood sampling and filling were out the questioners, Elisa test for anti CMV (IgM, IgG) was performed and the prevalence of these antibodies were calculated. Also, the prevalence of these antibodies was calculated according to age and a gender and long term follow up was done for the incidence of acute CMV infection following transplantation.
Results: 64 out of 70 patients (91/4%) had IgG-anti CMV. There was 38 male (59/4%) and 26 female (40/6%). Two of them who were female has had IgM anti CMV. person had IgM-anti CMV that both of them were female (100%).There was relationship between anti CMV IgG prevalence and age (p<0/05) and no relationship between anti CMV IgG and gender.
There was no relationship between anti CMV IgM and age/gender. Two cases (2/8%) of active CMV disease occurred during six months after transplantation , one of whom rejected the transplant.
Discussion: According to the prevalence of anti CMV IgG among the studied patients, there was a high risk of re infection which causing sever complication and transplant rejection .Therefore to prevent sever infection and resulting infection, it is recommended that CMV serology be performed before transplantation Also ,weekly PCR as a screening test and detecting anti genenia pp are recommended.
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