Evaluation of the Sensitivity of Acinetobacter sp. burn isolates to Ciprofloxacin and some of other used antibiotics for treatment

Introduction: Acinetobacter sp < /em>. is usually considered to be opportunistic pathogens.  They are often multi-resistant to antibiotics, meaning that therapy and infection control are complicated. The relative effectiveness of ciprofloxacin in treatment of Acinetobacter infections has been shown in several studies, more ever detection of different susceptibilities to ciprofloxacin among Acinetobacter sp. is important for treatment of Acinetobacter infections. The aim of present study was to evaluate the sensitivity of 48 burn isolates of Acinetobacter to ciprofloxacin.

Materials and Methods: In this Descriptive Cross-sectional survey, 48 bacterial isolates were collected from burn wards of hospitals in Tehran, Iran. The isolates were further processed by the standard methods to identify as the Acinetobacter sp < /em>. The susceptibilities of isolates to different antibiotics were tested using agar disk diffusion method. Antibacterial activity of ciprofloxacin was measured by serial dilution of the antibiotic in broth media.

 Results: All the isolates were recognized as Acinetobacter baumannii. The average MBCs of ciprofloxacin against all strains of Acinetobacter sp. were 37.9 ± 33.1 μg mL-1. The rates of resistances were determined to antibiotics as follows: gentamicin 70.8%, ticarcillin 93.7%, ceftizoxime 75%, co-trimoxazole 79.1%, amikacin 52%, carbenicillin 93.7%, cefalotin 60.4%, cefazolin 100% piperacillin 88.9%, imipenem 14.6%, kanamycin 95.8%, and ofloxacin 95.8%.

Discussion and Conclusion: All of the isolates were resistant to ciprofloxacin. This data remind the worldwide emerging resistance against ciprofloxacin, and this is a serious problem in therapeutic management of Acinetobacter infections and has a local and worldwide concern since many ciprofloxacin resistant Acinetobacter isolates were also multi drug resistant strains