Comparison of Doppler ultrasonographic indices before and after cyclosporine A peak serum level in stable kidney transplanted recipients

Comparison of Doppler ultrasonographic indices before and after cyclosporine A peak serum level in stable kidney transplanted recipients Abstract: Background: Doppler ultrasonography is the best tool for assessment of transplanted kidneys’ vascular status. On the other hand cyclosporine A widely consume to prevent graft rejection, has some vasoconstriction effects influence the Doppler parameters. To date, there has been little agreement on this effect. This paper will focus on the evaluation of whether cyclosporine A was affect the Doppler parameters. Materials and methods: A cross-sectional study was performed on 31 stable patients, between 6-18 months after transplantation. All patients were received immunocompromised treatment including cyclosporine A. Interarenal Doppler indices, resistive index (RI) and pulsatility index and end diastolic velocity (EDV) and peak systolic velocity (PSV) were measured at interlobar artery level before and 2 hour after (peak serum level) the oral intake of cyclosporine A. Data analysis were made by SPSS software to estimate the influence of cyclosporine A on the Doppler parameters. Results: compared with Doppler parameters before and 2hour after cyclosporine A, among patients with mean serum creatinin levels about 1.3, values remained unchanged. Conclusion: In this study, consumption of cyclosporine A dose not lead to acute rise in ultrasonographic Doppler indices.