Study on the effect of 4-weeks treatment of the aqueous extract of the roots of orchid plants on the serum concentration of colecystokinin hormone and body weight in male rats

Authors
hossein kargar jahromy
zahra Kargar Jahromi
zahra Khabbaz Kherameh
HamidReza Dowlatkhah
10.29252/jmj.13.1.15
Abstract
Background and objective: The growing trend of obesity is one of the biggest health challenges in the world. Stimulating the metabolism and increasing in energy using plant materials is one of the considerable methods to treat obesity. The aim of this study was to investigate the effect of aqueous extract of orchid plant roots on colecystokinin hormone serum levels and body weight in male rats. Materials and Methods: In this experimental study, 50 adult male Wistar rats were selected and randomly divided into 5 groups equally: control (no drug), sham(which received 1 ml of distilled water), the experimental group 1 (receiver 20 mg / kg aqueous extract of orchid plant roots), experimental group 2 (receiving 40 mg / kg aqueous extract of orchid ) and experimental group 3 (receiver 80 mg / kg aqueous extract of orchid plant). In the experimental groups, the extract was injected intraperitoneally for 28 days. In the twenty-ninth day, the mice were bled for the assessment of colecystokinin hormone serum level. Body weight was measured daily throughout the experiment. Findings: the dose-dependently injection of the aqueous extract of the orchid plant roots led to a significant increase in colesyctokitin hormone serum level and significant decrease in food intake and body weight in comparison to control (p<0.05). Conclusion: The aqueous extract of the orchid plants roots reduces the body weight by increasing colecystokinin hormone serum level.
Keywords
orchid
colecystokinin
Body weight
Male Rat