Pars Journal of Medical Sciences

Frequency of Group B Streptococcus Colonization in pregnant women in Jahrom, 2014

Authors

Abstract

Introduction: Group B Streptococcous (GBS) is a leading cause of neonatal infections such as meningitis and septicemia and plays a significant role in maternal infections including pyelonephritis, chorioamnionitis, and post partum infection. Diagnosis and treatment of these infections can reduce maternal and neonatal morbidity and mortality. So the aim of this study is Prevalence of Group B Streptococcus Colonization in The 35 - 37 weeks of Pregnancy referring to Honari clinic in Jahrom, 2014. Materials & Methods: In this study, 403 pregnant women in The 35 - 37 weeks referring to Honari clinic in Jahrom, (after explaining the study, getting informed onsent and demographic informations) rectal and vaginal samples were taken. The samples were placed in transport media, transported to the Laboratory and tested for GBS. Data were analyzed by SPSS software, Fisher tests and Chi square Results: In this study, the prevalence of positive vaginal, rectal and rectovaginal GBS culture in pregnant women were 16.4%, 5.2% and 1.7% respectively. There werer significant correlation found between this positive cultures and maternal age, genital diseases status and pregnancy induced hypertension, but no significant correlation found between this positive cultures and abortion status, diabetes mellitus, Disease after birth mom status, Preterm delivery, Urinary infection status, Location, Nationality, education level, disease after birth in The baby and section. Conclusion:According to the high prevalence (19/9%) GBS colonization in pregnant women in Jahrom should present appropriate solutions for the prevention of invasive infection in mothers and infants infected.

Keywords

References: 1. Lee I.S, Chu J, Heo D.F, Calvisi Z, Sun T, Roskams A. Durnez, A.J. Demetris. Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling.J.S. Hepatology,2004; 667–676. 2. X.P. Chen, F.Z. Qiu, Z.D. Wu, Z.W. Zhang, Z.Y. Huang, Y.F. Chen, Br. Long-term outcome of resection of large hepatocellular carcinoma, J. Surg. 93,2006; 600–606. 3. Kavazis AN, Smuder AJ, Min K, et al. Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72. Am J Physiol Heart 2010; 299: 1515–1524. 4. Maksimenkoa A, Dosiob F, Mougina J, et al. A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity. Published online January 2, 2014; E217–E226. 5. Szabolcs G, Csaba H, Petra L, et al. High Throughput Screening Identifies a Novel Compound Protecting Cardiomyocytes from Doxorubicin-Induced Damage. Oxidative Medicine and Cellular Longevity 2015; Article ID 178513, 1-12 pages 6. Ashrafi J, Dabidi Roshan V. Is Short-term Exercise a Therapeutic Tool for Improvement of Cardioprotection Against DOX-induced Cardiotoxicity? An Experimental Controlled Protocol in Rats. Asian Pacific J Cancer Prev 2012; 13: 4025-4030. 7. Ascensao A, Oliviera PJ, Magalhaes, J. Exercise as a beneficial adjunct therapy during Doxorubicin treatment-Role of mitochondria in cardio protection. Int J Cardiol 2012; 156: 4-10. 8. Martins R A, Minari AL, Chaves MD, et al. Exercise preconditioning modulates genotoxicity induced by doxorubicin in multiple organs of rats. Cell Biochem Funct 2012; 30: 293-296. 9. Li M, XiongZh G. Ion channels as targets for cancer therapy. Int J Physiol Pathophysiol Pharmaco 2011; l: 3(2):156-166. 10. Wang G, Zhang J, Liu L, et al. Quercetin potentiates doxorubicin mediated antitumor effects against liver cancer through p53/Bcl-xl. PLoS One. Doi 2012; 10.1371. 11. Chen CT, Wang ZH, Hsu C.Ch, et al. In Vivo Protective Effects of Diosgenin against Doxorubicin-Induced Cardiotoxicity. Nutr 2015; 7, 4938-4954; doi:10.3390/nu7064938 12. Cheung K G, Cole LK, Xiang B, et al. SIRT3 attenuates doxorubicin-induced oxidative stress and improves mitochondrial respiration in H9c2 cardiomyocytes. JBC Papers in Press 2015; M114.607960 13. Ascensao A, Magalhaes J, Soares J, et al. Endurance training attenuates doxorubicin-induced cardiac oxidative damage in mice. Int J Cardiol 2005; 100: 451–460. 14. Ascensao A, Magalhaes J, Soares JM, et al. Moderate endurance training prevents doxorubicin-induced in vivo mitochondriopathy and reduces the development of cardiac apoptosis. Am J Physiol Heart CircPhysiol 2005; 289: H722–H73. 15. Serpil C, Gulsen C, Fatma G. O, et al. Hepatoprotective Effect of 17β-stradiol as Antioxidant Modulators Against Stress Damage. Hepat Mon 2015; 15(2): e22633. 16. Tayeb W, Nakbi A, Trabelsi M, et al. Hepatotoxicity induced by sub-acute exposure of rats to 2,4-Dichlorophenoxyacetic acid based herbicide “Désormone lourd”. J.Hazard Mater 2010; 180: 225-233. 17. Viswanatha SA, Gulliaya S, Thippeswamy A, et al. Cardioprotective effect of curcumin against oxorubicin-induced myocardial toxicity in albino rats. Indian J Pharmacol 2012; 44(1): 73–7. 18. Zolfagharzadeh F, Dabidi Roshan V. Pretreatment hepatoprotective effect of regular aerobic training against hepatic toxicity induced by doxorubicin in rats. Asian Pacific J Cancer Prev 2013;14(5):5227-32. 19. Asea BK, Pedersen. Heat Shock Proteins and Whole Body Physiology, Springer Science+Business Media B.V 2010; 57–83 & 217–240. 20. Gibson1 OR. Mee1 J. ATaylor L, et al. Isothermic and fixed-intensity heat acclimation methods elicit equal increases in Hsp72 mRNA. Scand J Med Sci Sports 2015; 25 (Suppl. 1): 259–268 21. Injac R, Perse M, Cerne M, et al. Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer. Biomater 2009; 30|: 1184-96. 22. Krause M, Rodrigues-Krause J. Extracellular heat shock proteins (eHSP70) in exercise: Possible targets outside the immune system and their role for neurodegenerative disorders treatment. Med Hypothesis 2011; 76: 286-290. 23. Ruell PA, Thompson MW, Hoffman KM. Heat shock proteins as an aid in the treatment and diagnosis of heat stroke. J Thermal Biol 2009; 34, 1-7. 24. Brian G, Vicente R, Jamie A, et al. HSP72 Is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism,and Insulin Sensitivity in Skeletal Muscle. Diabetes 2014; 63:1488–1505 25. Dabidi-Roshan V, Rahnama N, Abdi Hamzehkolaei H, et al. Heat shock protein responses to eccentric weight or treadmill exercise in active young females Sport Sci Health 2009; 5: 75–80. 26. Kavazis AN, Smuder AJ, Min K, et al. Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72. Am J Physiol Heart CircPhysiol 2010; 299(5):H1515-24. 27. Ascensão A, Oliveira PJ, Magalhães J. Exercise as a beneficial adjunct therapy during Doxorubicin treatment—Role of itochondria in cardioprotection. Int J Cardiol 2012; 156:4–10. 28. Henninger C, Huelsenbeck J, Huelsenbeck S, Grösch S, Schad A, Lackner KJ, et al. The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity. Toxicol Appl Pharmacol 2012;261(1):66-73. 29. Binder RJ. Heat-shock protein-based vaccines for cancer and infectious disease.Expert Rev Vaccines 2008; 7 (3): 383–93. 30. Nishikawa M, Takemoto S, Takakura Y. Heat shock protein derivatives for delivery of antigens to antigen presenting cells".Int J Pharm 2008; 354: (1–2): 23–7. 31. Raschi, E, Vasina V, Ursino M, et al. Anticancer drugs and cardiotoxicity: Insights and perspectives in the era of targeted therapy. Pharmacol Ther 2010;125:196–218. 32. Swamy AV, Gulliaya S, Thippeswamy A, et al. Cardioprotective effect of curcumin against doxorubicin- induced myocardial toxicity in albino rats. Indian J Pharmacol 2012; 44: 73–77. 33. Chatterjee K, Zhang J, Honbo N, et al. Doxorubicin Cardiomyopathy. Cardiology 2010; 115:155–162. 34. Chen B, Peng X, Pentassuglia L, et al. Molecular and cellular mechanisms of anthracycline cardiotoxicity. Cardiovasc Toxicol 2007;7: 114−121. 35. Tsitsimpikou C, Kioukia-Fougia N, Tsarouhas K, et al. Administration of tomato juice ameliorates lactate dehydrogenase and creatinine kinase responses to anaerobic training. Food Chem Toxicol Doi 2013; 10.1016. 36. Ogonovsky H, Sasvari M, Dosek A, et al. The effects of moderate, strenuous and overtraining on oxidative stress markers and DNA repair in rat liver. Can J Appl physiol 2005; 30: 186-95.