Introduction: Lead is one of the toxic and heavy metals that had different effects and side effects on biological systems of living creatures suchas humon, also, it causes various risks such as infertility. This study investigate antioxidant effect of cinnamon on elimination of lead poisoning in reproductive system in order to find a solutim for the problem of people in facing with lead.

Materials and methods: The animals in this into 7 groups of 6 rats that includes one control group which received no remedy, control group 1 (solvent), control group 2 (0.6 g/l lead acetate daily), control group 3 (1.5 g/kg cinnamon extract daily), experimental group 1,2,3 that daily received 0.6 g/l lead acetate in addition to respectively received 0.1, 0.2 , 0.5 g/kg cinnamon extract for 14 days. Then, statistical data determineal significantly by ANOVA (one – way analysis of variance) through SPSS software , version 18.

Results: The results shows that The concentration of the hormone estrogen decreased in control group 2 and increased in control group 3 signiticantly compared to control group in 5% level. The concentrate of hormone progesterone decreased in control group 2 and increased in control group 3 significantly compared to control group.

Conclusion: The results of this study indicates that cinnamon extract in a dose dependent manner and with antioxidant properties reduces the side effects of lead on sex hormones.