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:: Volume 14, Issue 3 (fall 2016) ::
jmj 2016, 14(3): 27-34 Back to browse issues page
The Effect of resistance training circuit with Medicago sativa extracts on levels of Osteoprotegerin and Nuclear Factor of Kappa-B in thin girls
Parvin Farzanegi *, Khatereh Ebrahimi, Masoumeh Habibian
Abstract:   (4297 Views)



 Osteoporosis is the most common metabolic bone disease with high prevalence that various factors are involved in the pathogenesis of this disease, including the low body mass index and lack of physical activity. Change in lifestyle represents a successful strategy to prevent future disease. Therefore the aim of this study was determine the interactive effects of resistance training and Medicago sativa extracts consumption on serum level of steoprotegerin and nuclear factor kappa B in thin girls.

Materials and Methods:

In one Quasi-experimental study, 28 female students (16 to 19 years) divided into 4 groups, including: supplement, training , training-supplement and Control randomly. Resistance training program consisted of 10 exercise movements at 60-80% of one repeated maximal in 8-12 repetition (in 3 circuits), 60 min per day and 3 sessions per week for 4 weeks. Intake Medicago sativa supplement was 1 ml/kg body weight for 3 times a day. Data were analyzed with Paired t and ANOVA tests ( P<0.05) .


Four weeks of resistance training, supplementation and the combined intervention were associated with a significant increase in steoprotegerin and  decrease in nuclear factor kappa B levels (P<0/05) in thin girls. Furthermore combined intervention were associated with greater changes in percent changes of these inducator compare training and supplement groups (p<0.05).


Regular resistance training with consumption of Medicago sativa extracts as a non-drug therapy can increase bone formation markers and also reduce the activity of the absorbency pathway in thin adolescent girls. Of course the combination of exercise and supplement are more effective than the separate effects of each them.

Keywords: Resistance training, Medicago sativa, steoprotegerin, nuclear factor kappa B, thinness.
Full-Text [PDF 428 kb]   (1461 Downloads)    
Type of Study: Research | Subject: Physiology varzeshi
Received: 2016/06/11 | Revised: 2017/06/12 | Accepted: 2016/11/9
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farzanegi P, ebrahimi K, habibian M. The Effect of resistance training circuit with Medicago sativa extracts on levels of Osteoprotegerin and Nuclear Factor of Kappa-B in thin girls. jmj 2016; 14 (3) :27-34
URL: http://jmj.jums.ac.ir/article-1-768-en.html

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Volume 14, Issue 3 (fall 2016) Back to browse issues page
فصلنامه دانشگاه علوم پزشکی جهرم Journal of Jahrom University of Medical Sciences
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