[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 13, Issue 4 (winter 2015) ::
jmj 2015, 13(4): 47-55 Back to browse issues page
In vitro study of antibacterial effect of new thiazole, imidazole and tetrahydropyridine derivatives against Proteus vulgaris
Ghasemi Behzad *, Beizaei Hamid, Najimi Mohsen
Abstract:   (4244 Views)

Introduction:

Proteus vulgaris is one of a nosocomial pathogens and recently, the spread of antibiotic-resistance of this bacterium has encouraged researchers to investigate new antibacterial agents against it. Thiazole, imidazolidin and tetrahydropyridine derivatives are new antibacterial compounds that their inhibitory effects have proved against many pathogenic bacteria. In this study, antibacterial effects of 15 new thiazole, imidazolidin and tetrahydropyridine derivatives has evaluated against P. vulgaris.

Materials and Methods:

In this study, a solution of all the synthesized derivatives were prepared in DMSO as solvent, the antibacterial effects of derivatives were evaluated using disk diffusion and microdilution methods in order to measure zone diameters of bacterial growth inhibition and determine the minimum inhibitory concentration (MIC), respectively.

Results:

Results showed that imidazole and tetrahydropyridine derivatives 9a-g and thiazole derivatives 6a-c, 10a and 10c had any inhibitory effect on P. vulgaris, only, inhibitory effects of three thiazole derivatives 6d, 9 and 10b were observed with zone diameters of bacterial growth inhibition of 22.1±0.2, 10.2±0.1 and 4.3±0.1 mm and MIC of 128, 512 and 1024 μg/ml on P. vulgaris, respectively.

Conclusion:

In this research, antibacterial effect of some new thiazole derivatives (6d, 9 and 10b) was proved on standard strains of P. vulgaris and to use the compounds as medicines, their effects must be evaluated on drug-resistant strains of P. vulgaris in future studies.

Keywords: antibacterial effect, thiazoles, imidazoles, tetrahydropyridines, P. vulgaris.
Full-Text [PDF 675 kb]   (6175 Downloads)    
Type of Study: Research | Subject: Microbshensi
Received: 2015/09/9 | Revised: 2017/06/21 | Accepted: 2016/03/7
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Behzad G, Hamid B, Mohsen N. In vitro study of antibacterial effect of new thiazole, imidazole and tetrahydropyridine derivatives against Proteus vulgaris. jmj. 2015; 13 (4) :47-55
URL: http://jmj.jums.ac.ir/article-1-605-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 13, Issue 4 (winter 2015) Back to browse issues page
فصلنامه دانشگاه علوم پزشکی جهرم Journal of Jahrom University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 4419