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:: Volume 16, Issue 4 (winter 2018) ::
jmj 2018, 16(4): 19-29 Back to browse issues page
The effect of Saccharin on spermatogenes, testiscular tissue and pituitary –gonad hormones axis in rats
Reza Paknejad , Vahid Hemayatkhah Jahromi *
Abstract:   (2442 Views)
Saccharin is an artificial, non-caloric sweetener used to sweeten products such as beverages, confectionary, biscuits, medicines and tooth pastes. This is while our body is not able to metabolized it. In the present study, the effect of saccharin on spermatogenesis, testicular tissue structure and pituitary-gonadal hormone axis in rats was investigated.
Material and Methods: 35 adult male Wistar rats were divided into five equal groups. The control group did not receive any solvent or drug. The sham group received 1ml distilled water per day as an intraperitoneal injection.  Experimental 1,2 and 3 groups received times daily, respectively 250,500 and 1000 mg/kg body weight saccharin intraperitoneal for 35 days. After about35 days, blood was taken from the animals and testicular tissue was isolated to examine the tissue. Data were analyzed by SPSS version 16 and one wayANOVA and post hoc Duncan test.
Results:The level of glucose in the experimental groups was significantly higher than the control group(p≤0.05).The concentration of testosterone DHEA, LH and FSH hormone in the experimental groups  had significant decrease than control group.
Also the numbers of spermatogonia, primary and secondary spermatocyte, Spermatid, Spermatozoide and sperm in the experimental groups had significant decrease than control and sham groups. But Sertoli and Leydig cells indicated no significant difference(p≤0.05).
Conclusions:Saccharin can affect the amounts of hormones and sex cells male devastating effects have and these influences will perhaps amount  to less to human generalized. Of course, in this case, how and the amount of the artificial sweetener used is very important
Keywords: Saccharin, Testis, Pituitary – Gonad Hormones Axis, Rat
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Type of Study: Letter to Editor | Subject: phatology
Received: 2018/09/2 | Revised: 2020/12/26 | Accepted: 2019/02/18
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Paknejad R, Hemayatkhah Jahromi V. The effect of Saccharin on spermatogenes, testiscular tissue and pituitary –gonad hormones axis in rats. jmj. 2018; 16 (4) :19-29
URL: http://jmj.jums.ac.ir/article-1-1199-en.html

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Volume 16, Issue 4 (winter 2018) Back to browse issues page
فصلنامه دانشگاه علوم پزشکی جهرم Journal of Jahrom University of Medical Sciences
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