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:: Volume 19, Issue 4 (winter 2021) ::
jmj 2021, 19(4): 53-62 Back to browse issues page
Effect of Coenzyme Q10 on oxidative/antioxidative biomarkers level in the testis of streptozotocin-induced diabetic rats
Mehri Rezaei , Maryam Baazm , Ali Khosrobeghi , Fatemeh Samimi , Farideh Jalali Mashayekhi *
Arak University of Medical Sciences, Arak, Iran
Abstract:   (598 Views)
Background and Aim: Oxidative stress, through the production of reactive oxygen species (ROS), has been proposed as the root cause underlying the development of diabetes and its related complications such as testicular tissue damage.
 Antioxidants supplementation have been reported to improve testicular function and oxidative stress-induced in diabetes.The study aimed to determine the Coenzyme Q10 (CoQ10) effects on the oxidative status in the testicular tissue of streptozotocin-induced diabetic rats.
Materials and Methods: In the experimental study, 30 male Wistar rats were studied. The rats were randomly divided into four 5-rat groups including: saline, sesame oil (as a vehicle), healthy group treated with CoQ10 (10 mg/kg/day), diabetic (induced with streptozotocin: 55 mg/kg), and CoQ10-treated diabetic (10 mg/kg/d). Then, levels of Malondialdehyde (MDA), Total Oxidant Status (TOS), and Total Antioxidant Capacity (TAC) and Oxidative stress index) OSI were measured in the homogenized of testicular tissue.
Results: Analysis of data showed a significant decrease in the level of testis MDA (P=0.001), TAC (P=0.029) and OSI (P=0.033) in the CoQ10-treated diabetic group compared to the diabetic rats. No significant change was observed in the TOS (P=0.529) level in diabetic rats' testis treated with CoQ10 compared to diabetic rats.
Conclusion: Collectively, our results demonstrated the possible effects of CoQ10 in attenuating diabetes-induced oxidative damage, in testicular tissue.
Keywords: Coenzyme Q10, Diabetes mellitus, Malondialdehyde, Oxidative stress index
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Type of Study: Research | Subject: Biochemestry
Received: 2021/06/30 | Revised: 2022/04/18 | Accepted: 2022/01/30
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Research code: 6216
Ethics code: IR.ARAKMU.REC.1399.196


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Rezaei M, Baazm M, Khosrobeghi A, Samimi F, Jalali Mashayekhi F. Effect of Coenzyme Q10 on oxidative/antioxidative biomarkers level in the testis of streptozotocin-induced diabetic rats. jmj. 2021; 19 (4) :53-62
URL: http://jmj.jums.ac.ir/article-1-1625-en.html


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Volume 19, Issue 4 (winter 2021) Back to browse issues page
فصلنامه دانشگاه علوم پزشکی جهرم Journal of Jahrom University of Medical Sciences
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