[1]. Rajaei F, Rad JS, Niknafs B, et al. "Effect of vitrification on apoptosis in mouse blastocysts". J Reprod Infertil; 7: 14-22. (2004). [2]. Aggarwal BB, Surh YJ, Shihsodia S (Ed).: "The molecular targets and therapeutic uses of curcumin in health and disease". Adv Exp Med Biol 595; 8: (2007). [3]. Feizolahi F, Azarbayjani MA, Nasehi M, et al. "Comparison the Effect of Short-term Swimming Training and Curcumin Supplementation on Damaged Spatial Memory after Binge Ethanol Drinking in Male Rats: Preliminary Report". Journal of Medicinal Plants”, 16(10), 174-184, (2016). [4]. Moradi Kelardeh B, Azarbayjani MA, Peeri M, et al. "Effect of Curcumin Supplementation and Resistance Training in Patients with Nonalcoholic Fatty Liver Disease". Journal of Medicinal Plants. 15(60), 161-172, (2016). [5]. Geng, Hai-Hua, Rui Li, Ya-Min Su, Jie Xiao, Min Pan, Xing-Xing Cai, and Xiao-Ping Ji. "Curcumin protects cardiac myocyte against hypoxia-induced apoptosis through upregulating miR-7a/b expression." Biomedicine & Pharmacotherapy 81 (2016): 258-264. [6]. Marfe, Gabriella, Marco Tafani, Bruna Pucci, Carla Di Stefano, Manuela Indelicato, Angela Andreoli, Matteo Antonio Russo, Paola Sinibaldi-Salimei, and Vincenzo Manzi. "RETRACTED ARTICLE: The effect of marathon on mRNA expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners." BMC physiology 10, no. 1 (2010): 7. [7]. Ahmadiasl, Nasser, Farhad Ghadiri Soufi, Mohammadreza Alipour, Mohammadreza Bonyadi, Farzam Sheikhzadeh, Amirmansour Vatankhah, Iraj Salehi, and Mehran Mesgari. "Effects of age increment and 36-week exercise training on antioxidant enzymes and apoptosis in rat heart tissue." Journal of sports science & medicine 6, no. 2 (2007): 243. [8]. Amirkhani Z, Azarbayjani MA, MatinHomaee H, Pri M, “Effect of Combining Resistance Training and Curcumin Supplementation on Lipid Profile in Inactive Obese and Overweight Females”, Iranian Journal of Obstetrics, Gynecology and Infertility, 2017. [9]. Rezai SH, Matin homaee H, Azarbayjani MA. et al. " The Effect of Intense and Moderate Interval Aerobic Exercise and Curcumin Consumption on the Gene Expression of c-Kit in Stem Cells of Old Rats Heart". Journal of Fasa University of Medical Sciences. 6(1), (2016). [10]. Jafari A, Pourrazi H, Nikookheslat S, and Baradaran B. "Effect of Exercise Training on Bcl-2 and Bax Gene Expression in the Rat Heart." Gene, Cell and Tissue, 2(4), (2015). [11]. Jafari, M., Shirbazou, S., Sadraie, S.H., Kaka, G. and Norozi, M., 2015. The role of apoptosis in the cellular response of liver and spleen of BALB/c mice in cutaneous leishmaniasis. Iranian journal of medical sciences, 40(2), p.133. [12]. Suliman, Ayoub, Arh Lam, Rakesh Datta, and Rakesh K. Srivastava. "Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and-independent pathways." Oncogene 20, no. 17 (2001): 2122-2133. [13]. Kroemer, Guido. "Mitochondrial control of apoptosis: an introduction." Biochemical and biophysical research communications 304, no. 3 (2003): 433-435. [14]. KOSTANECKI, K., J. MIŁOBĘDZKA, and W. LAMPE. "Zur Kenntnis des Curcumins." Berichte der Deutschen Chemischen Gesellschaft 43, no. 2 (1910): 2163-2170. [15]. Wang, Yuehong, Jinjun Zhao, Wei Yang, Yayan Bi, Jing Chi, Juanjuan Tian, and Weimin Li. "High-dose alcohol induces reactive oxygen species-mediated apoptosis via PKC-β/p66Shc in mouse primary cardiomyocytes." Biochemical and biophysical research communications 456, no. 2 (2015): 656-661. [16]. Maheshwari, R.K.; Singh, A.K.; Gaddipati, J.; Srimal, R.C. “Multiple biological activities of curcumin: A short review”, Life Sci. )2006(, 78(18), 2081-2087. [17]. Yu, Linsheng, Yanyan Fan, Guanghua Ye, Junli Li, Xiangping Feng, Kezhi Lin, Miuwu Dong, and Zhenyuan Wang. "Curcumin inhibits apoptosis and brain edema induced by hypoxia-hypercapnia brain damage in rat models." The American journal of the medical sciences, 349(6), (2015): 521-525. [18]. Manna P., Das J., Ghosh J., Sil P.C. “Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid”, Free Radic Biol Med, )2010(, 48 (11):1465-84. [19]. Tao, Pei, Haiyan Yin, and Yonghui Ma. "Study of the mechanisms of curcumin on mitochondrial permeability transition of hepatocytes in rats with sepsis." Zhonghua wei zhong bing ji jiu yi xue 26, no. 9 (2014): 666-670. [20]. Somasundaram, Sivagurunathan, Natalie A. Edmund, Dominic T. Moore, George W. Small, Yue Y. Shi, and Robert Z. Orlowski. "Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer." Cancer research 62, no. 13 (2002): 3868-3875. [21]. Ghoneim, Asser I. "Effects of curcumin on ethanol-induced hepatocyte necrosis and apoptosis: implication of lipid peroxidation and cytochrome c." Naunyn-Schmiedeberg's archives of pharmacology, 379(1), (2009): 47-60. [22]. Samuhasaneeto, Suchittra, Duangporn Thong-Ngam, Onanong Kulaputana, Doungsamon Suyasunanont, and Naruemon Klaikeaw. "Curcumin Decreased Oxidative Stress, Inhibited NF-𝜅 B Activation, and Improved Liver Pathology in Ethanol-Induced Liver Injury in Rats." BioMed Research International, (2009). [23]. Tiwari, Vinod, and Kanwaljit Chopra. "Attenuation of oxidative stress, neuroinflammation, and apoptosis by curcumin prevents cognitive deficits in rats postnatally exposed to ethanol." Psychopharmacology (2012): 1-17. [24]. Bulku, Elida, Sidney J Stohs, Lorraine Cicero, Tracy Brooks, Herb Halley, and Sidhartha D Ray. "Curcumin exposure modulates multiple pro-apoptotic and anti-apoptotic signaling pathways to antagonize acetaminophen-induced toxicity." Current neurovascular research 9, no. 1 (2012): 58-71. [25]. Wang, Long. "Curcumin prevents the non-alcoholic fatty hepatitis via mitochondria protection and apoptosis reduction." International journal of clinical and experimental pathology 8, no. 9 (2015): 11503. [26]. Motaghinejad, Majid, Morteza Karimian, Ozra Motaghinejad, Behnaz Shabab, Iraj Yazdani, and Sulail Fatima. "Protective effects of various dosage of Curcumin against morphine induced apoptosis and oxidative stress in rat isolated hippocampus." Pharmacological Reports 67, no. 2 (2015): 230-235 [27]. Yu, Wei, Wenliang Zha, Zhiqiang Ke, Qing Min, Cairong Li, Huirong Sun, and Chao Liu. "Curcumin protects neonatal rat cardiomyocytes against high glucose-induced apoptosis via PI3K/Akt signalling pathway." Journal of diabetes research (2016) [28]. Yan, Xiaochen, Bo Pan, Tiewei Lv, Lingjuan Liu, Jing Zhu, Wen Shen, Xupei Huang, and Jie Tian. "Inhibition of histone acetylation by curcumin reduces alcohol-induced fetal cardiac apoptosis." Journal of biomedical science 24, no. 1 (2017): 1. [29]. Shin, Hyun Joo, Ji Yeong Lee, Eunyung Son, Dong Hun Lee, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, and Gu Seob Roh. "Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice." Neuroscience letters 416, no. 1 (2007): 49-54. [30]. Mirdar Harijani SH. Musavi N, Hamidian, Gh.R,.et al, "Effect of Endurance Swimming Training and Silymarin Treatment on Changes in Liver Apoptotic Index in Pregnant Rats Exposed to Cadmium", Journal Mediine university Rafssanjan, 13(8):705-714, (2014). [31]. Su, Shu-Hui, Chauying J. Jen, and Hsiun-ing Chen. "NO signaling in exercise training-induced anti-apoptotic effects in human neutrophils." Biochemical and biophysical research communications 405, no. 1 (2011): 58-63. [32]. Seppet, Enn, Ehte Orlova, Teet Seene, and Frank N. Gellerich. "Adaptation of cardiac and skeletal muscle mitochondria to endurance training: implications for cardiac protection." In Cardiac Adaptations, pp. 375-402. Springer New York, 2013. [33]. Higashi Y, Sukhanov S, Anwar A, Shai SY, Delafontaine P. “Aging, atherosclerosis, and IGF-1”, J Gerontol A Biol Sci Med Sci )2012(; 67(6):626-639. [34]. Li, Chun-Ying, Jae-Seon Lee, Young-Gyu Ko, Jong-Il Kim, and Jeong-Sun Seo. "Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation." Journal of Biological Chemistry 275, no. 33 (2000): 25665-25671. [35]. Beere, Helen M., Beni B. Wolf, Kelvin Cain, Dick D. Mosser, Artin Mahboubi, Tomomi Kuwana, Pankaj Tailor, Richard I. Morimoto, Gerald M. Cohen, and Douglas R. Green. "Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome." Nature cell biology, 2(8), (2000): 469-475. [36]. Reed, John C. "Apoptosis-regulating proteins as targets for drug discovery." Trends in molecular medicine, 7(7), (2001): 314-319. [37]. Radak, Zsolt, Shuzo Kumagai, Hideko Nakamoto, and Sataro Goto. "8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats." Journal of Applied Physiology, 102(4) (2007): 1696-1701. [38]. Huang, Chih-Yang, Ai-Lun Yang, Yueh-Min Lin, Fan-Ni Wu, James A. Lin, Yi-Sheng Chan, Fuu-Jen Tsai, Chang-Hai Tsai, Chia-Hua Kuo, and Shin-Da Lee. "Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts." Journal of applied physiology 112, no. 5 (2012): 883-891. [39]. Siu, Parco M., Randall W. Bryner, Julie K. Martyn, and Stephen E. Alway. "Apoptotic adaptations from exercise training in skeletal and cardiac muscles." The FASEB Journal, 18(10), (2004): 1150-1152. [40]. Quindry, John, Joel French, Karyn Hamilton, Youngil Lee, Jawahar L. Mehta, and Scott Powers. "Exercise training provides cardioprotection against ischemia–reperfusion induced apoptosis in young and old animals." Experimental gerontology, 40(5), (2005): 416- 425. [41]. Delchev, S., K. Georgieva, Y. Koeva, and P. Atanassova. "Bcl-2 and Bax Expression in Rat Myocardium after Acute Exercise and Endurance Training." In Proceeding of the Balkan Scientific Conference of Biology in Plovdiv (Bulgaria), pp. 19-21. )2005(. [42]. Kavazis A N, “Exercise preconditioning of the myocardium”. Sports Med 39(11), (2009) 923-935. [43]. Peterson, Jonathan M., Randall W. Bryner, Amy Sindler, Jefferson C. Frisbee, and Stephen E. Alway. "Mitochondrial apoptotic signaling is elevated in cardiac but not skeletal muscle in the obese Zucker rat and is reduced with aerobic exercise." Journal of applied physiology 105, no. 6 (2008): 1934 - 1943.‎ [44]. Cheng, Shiu-Min, Tsung-Jung Ho, Ai-Lun Yang, I-Ju Chen, Chung-Lan Kao, Fan-Ni Wu, James A. Lin et al. "Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats." International journal of cardiology 167, no. 2 (2013): 478-485. [45]. Lu, Kai, Li Wang, Changying Wang, Yuan Yang, Dayi Hu, and Rongjing Ding. "Effects of high-intensity interval versus continuous moderate‑intensity aerobic exercise on apoptosis, oxidative stress and metabolism of the infarcted myocardium in a rat model." Molecular medicine reports 12, no. 2 (2015): 2374-2382. [46]. Lee, S-D., W-C. Shyu, I-S. Cheng, C-H. Kuo, Y-S. Chan, Y-M. Lin, C-Y. Tasi, C-H. Tsai, T-J. Ho, and C-Y. Huang. "Effects of exercise training on cardiac apoptosis in obese rats." Nutrition, Metabolism and Cardiovascular Diseases 23, no. 6 (2013): 566-573. [47]. Choi, Jun-Ho, Tae-Soo Kim, Joon-Ki Park, Young-Je Sim, Kijeong Kim, and Sam-Jun Lee. "Short-term treadmill exercise preserves sensory-motor function through inhibiting apoptosis in the hippocampus of hypoxic ischemia injury rat pups." Journal of exercise rehabilitation, 9(5), (2013): 457. [48]. Santana, Eduardo Tadeu, Andrey Jorge Serra, José Antonio Silva Junior, Danilo Sales Bocalini, Valério Garrone Barauna, José Eduardo Krieger, and Paulo José Ferreira Tucci. "Aerobic exercise training induces an anti-apoptotic milieu in myocardial tissue." Motriz: Revista de Educação Física 20, no. 2 (2014): 233-238 [49]. Zhao, Y. C. "Effects of exercise training on myocardial mitochondrial miR-499-CaN-Drp-1 apoptotic pathway in mice." Zhongguo ying yong sheng li xue za zhi= Zhongguo yingyong shenglixue zazhi= Chinese journal of applied physiology, 31(3), (2015): 259-263. [50]. Doustar Y, Mohajeri D, Rezaei A, et al, "The effect of endurance swimming exercise on the occurrence of apoptosis in experimental diabetic myopathic rats", Journal of Islamic Azad Uni. 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[54].Sadat Hoseini S.K, Dabidi Roshan VA, " The interactive effects of two forced and voluntary exercise training method and Nanocurcumin supplement on doxorubicin-induced hepatotoxicity in aging induced by D-galactos". Tehran University Medical Journal TUMS Publications, 74(11), (2017): 807-816. [55]. Razavi Majd Z, Matin Homaee H, Azarbayjani MA, "Effects of Concurrent Regular Aerobic Training and Garlic Extract on Cardiac Tissue Apoptosis Markers in Aged Rats with Chronic Kidney Disease", Journal of Medicinal Plants. 2(62), (2017); 54-64. [56]. Zikaki, Kyriaki, Ioanna-Katerina Aggeli, Catherine Gaitanaki, and Isidoros Beis. "Curcumin induces the apoptotic intrinsic pathway via upregulation of reactive oxygen species and JNKs in H9c2 cardiac myoblasts." Apoptosis, 19(6), (2014): 958-974. [57]. Zhu, Lin, Ming Bao Han, Yuan Gao, Huan Wang, Ling Dai, Ying Wen, and Li Xin Na. "Curcumin triggers apoptosis via upregulation of Bax/Bcl-2 ratio and caspase activation in SW872 human adipocytes." Molecular medicine reports 12, no. 1 (2015): 1151-1156. [58]. El-Sayed, Eman M., Amal S. Abd El-azeem, Abeer A. Afify, Manal H. Shabana, and Hanaa H. Ahmed. "Cardioprotective effects of Curcuma longa L. extracts against doxorubicin-induced cardiotoxicity in rats." Journal of Medicinal Plants Research, 5(17) (2011): 4049-4058. [59]. Sandri, Marco, Ugo Carraro, Marzena Podhorska-Okolov, Corrado Rizzi, Paola Arslan, Daniela Monti, and Claudio Franceschi. "Apoptosis, DNA damage and ubiquitin expression in normal and mdx muscle fibers after exercise." FEBS letters 373, no. 3 (1995): 291-295. [60]. Qiguan, Jin. "The Effects of Chronic Exhaustive Training on Apoptosis of Muscles Rats [J]." SPORTS & SCIENCE, 5 (1999): 006. [1]. Rajaei F, Rad JS, Niknafs B, et al. "Effect of vitrification on apoptosis in mouse blastocysts". J Reprod Infertil; 7: 14-22. (2004). [2]. Aggarwal BB, Surh YJ, Shihsodia S (Ed).: "The molecular targets and therapeutic uses of curcumin in health and disease". Adv Exp Med Biol 595; 8: (2007). [3]. Feizolahi F, Azarbayjani MA, Nasehi M, et al. "Comparison the Effect of Short-term Swimming Training and Curcumin Supplementation on Damaged Spatial Memory after Binge Ethanol Drinking in Male Rats: Preliminary Report". Journal of Medicinal Plants”, 16(10), 174-184, (2016). [4]. Moradi Kelardeh B, Azarbayjani MA, Peeri M, et al. "Effect of Curcumin Supplementation and Resistance Training in Patients with Nonalcoholic Fatty Liver Disease". Journal of Medicinal Plants. 15(60), 161-172, (2016). [5]. Geng, Hai-Hua, Rui Li, Ya-Min Su, Jie Xiao, Min Pan, Xing-Xing Cai, and Xiao-Ping Ji. "Curcumin protects cardiac myocyte against hypoxia-induced apoptosis through upregulating miR-7a/b expression." Biomedicine & Pharmacotherapy 81 (2016): 258-264. [6]. Marfe, Gabriella, Marco Tafani, Bruna Pucci, Carla Di Stefano, Manuela Indelicato, Angela Andreoli, Matteo Antonio Russo, Paola Sinibaldi-Salimei, and Vincenzo Manzi. "RETRACTED ARTICLE: The effect of marathon on mRNA expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners." BMC physiology 10, no. 1 (2010): 7. [7]. Ahmadiasl, Nasser, Farhad Ghadiri Soufi, Mohammadreza Alipour, Mohammadreza Bonyadi, Farzam Sheikhzadeh, Amirmansour Vatankhah, Iraj Salehi, and Mehran Mesgari. "Effects of age increment and 36-week exercise training on antioxidant enzymes and apoptosis in rat heart tissue." Journal of sports science & medicine 6, no. 2 (2007): 243. [8]. Amirkhani Z, Azarbayjani MA, MatinHomaee H, Pri M, “Effect of Combining Resistance Training and Curcumin Supplementation on Lipid Profile in Inactive Obese and Overweight Females”, Iranian Journal of Obstetrics, Gynecology and Infertility, 2017. [9]. Rezai SH, Matin homaee H, Azarbayjani MA. et al. " The Effect of Intense and Moderate Interval Aerobic Exercise and Curcumin Consumption on the Gene Expression of c-Kit in Stem Cells of Old Rats Heart". Journal of Fasa University of Medical Sciences. 6(1), (2016). [10]. Jafari A, Pourrazi H, Nikookheslat S, and Baradaran B. "Effect of Exercise Training on Bcl-2 and Bax Gene Expression in the Rat Heart." Gene, Cell and Tissue, 2(4), (2015). [11]. Jafari, M., Shirbazou, S., Sadraie, S.H., Kaka, G. and Norozi, M., 2015. The role of apoptosis in the cellular response of liver and spleen of BALB/c mice in cutaneous leishmaniasis. Iranian journal of medical sciences, 40(2), p.133. [12]. Suliman, Ayoub, Arh Lam, Rakesh Datta, and Rakesh K. Srivastava. "Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and-independent pathways." Oncogene 20, no. 17 (2001): 2122-2133. [13]. Kroemer, Guido. "Mitochondrial control of apoptosis: an introduction." Biochemical and biophysical research communications 304, no. 3 (2003): 433-435. [14]. KOSTANECKI, K., J. MIŁOBĘDZKA, and W. LAMPE. "Zur Kenntnis des Curcumins." Berichte der Deutschen Chemischen Gesellschaft 43, no. 2 (1910): 2163-2170. [15]. Wang, Yuehong, Jinjun Zhao, Wei Yang, Yayan Bi, Jing Chi, Juanjuan Tian, and Weimin Li. "High-dose alcohol induces reactive oxygen species-mediated apoptosis via PKC-β/p66Shc in mouse primary cardiomyocytes." Biochemical and biophysical research communications 456, no. 2 (2015): 656-661. [16]. Maheshwari, R.K.; Singh, A.K.; Gaddipati, J.; Srimal, R.C. “Multiple biological activities of curcumin: A short review”, Life Sci. )2006(, 78(18), 2081-2087. [17]. Yu, Linsheng, Yanyan Fan, Guanghua Ye, Junli Li, Xiangping Feng, Kezhi Lin, Miuwu Dong, and Zhenyuan Wang. "Curcumin inhibits apoptosis and brain edema induced by hypoxia-hypercapnia brain damage in rat models." The American journal of the medical sciences, 349(6), (2015): 521-525. [18]. Manna P., Das J., Ghosh J., Sil P.C. “Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid”, Free Radic Biol Med, )2010(, 48 (11):1465-84. [19]. Tao, Pei, Haiyan Yin, and Yonghui Ma. "Study of the mechanisms of curcumin on mitochondrial permeability transition of hepatocytes in rats with sepsis." Zhonghua wei zhong bing ji jiu yi xue 26, no. 9 (2014): 666-670. [20]. Somasundaram, Sivagurunathan, Natalie A. Edmund, Dominic T. Moore, George W. Small, Yue Y. Shi, and Robert Z. Orlowski. "Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer." Cancer research 62, no. 13 (2002): 3868-3875. [21]. Ghoneim, Asser I. "Effects of curcumin on ethanol-induced hepatocyte necrosis and apoptosis: implication of lipid peroxidation and cytochrome c." Naunyn-Schmiedeberg's archives of pharmacology, 379(1), (2009): 47-60. [22]. Samuhasaneeto, Suchittra, Duangporn Thong-Ngam, Onanong Kulaputana, Doungsamon Suyasunanont, and Naruemon Klaikeaw. "Curcumin Decreased Oxidative Stress, Inhibited NF-𝜅 B Activation, and Improved Liver Pathology in Ethanol-Induced Liver Injury in Rats." BioMed Research International, (2009). [23]. Tiwari, Vinod, and Kanwaljit Chopra. "Attenuation of oxidative stress, neuroinflammation, and apoptosis by curcumin prevents cognitive deficits in rats postnatally exposed to ethanol." Psychopharmacology (2012): 1-17. [24]. Bulku, Elida, Sidney J Stohs, Lorraine Cicero, Tracy Brooks, Herb Halley, and Sidhartha D Ray. "Curcumin exposure modulates multiple pro-apoptotic and anti-apoptotic signaling pathways to antagonize acetaminophen-induced toxicity." Current neurovascular research 9, no. 1 (2012): 58-71. [25]. Wang, Long. "Curcumin prevents the non-alcoholic fatty hepatitis via mitochondria protection and apoptosis reduction." International journal of clinical and experimental pathology 8, no. 9 (2015): 11503. [26]. Motaghinejad, Majid, Morteza Karimian, Ozra Motaghinejad, Behnaz Shabab, Iraj Yazdani, and Sulail Fatima. "Protective effects of various dosage of Curcumin against morphine induced apoptosis and oxidative stress in rat isolated hippocampus." Pharmacological Reports 67, no. 2 (2015): 230-235 [27]. Yu, Wei, Wenliang Zha, Zhiqiang Ke, Qing Min, Cairong Li, Huirong Sun, and Chao Liu. "Curcumin protects neonatal rat cardiomyocytes against high glucose-induced apoptosis via PI3K/Akt signalling pathway." Journal of diabetes research (2016) [28]. Yan, Xiaochen, Bo Pan, Tiewei Lv, Lingjuan Liu, Jing Zhu, Wen Shen, Xupei Huang, and Jie Tian. "Inhibition of histone acetylation by curcumin reduces alcohol-induced fetal cardiac apoptosis." Journal of biomedical science 24, no. 1 (2017): 1. [29]. Shin, Hyun Joo, Ji Yeong Lee, Eunyung Son, Dong Hun Lee, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, and Gu Seob Roh. "Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice." Neuroscience letters 416, no. 1 (2007): 49-54. [30]. Mirdar Harijani SH. Musavi N, Hamidian, Gh.R,.et al, "Effect of Endurance Swimming Training and Silymarin Treatment on Changes in Liver Apoptotic Index in Pregnant Rats Exposed to Cadmium", Journal Mediine university Rafssanjan, 13(8):705-714, (2014). [31]. Su, Shu-Hui, Chauying J. Jen, and Hsiun-ing Chen. "NO signaling in exercise training-induced anti-apoptotic effects in human neutrophils." Biochemical and biophysical research communications 405, no. 1 (2011): 58-63. [32]. Seppet, Enn, Ehte Orlova, Teet Seene, and Frank N. Gellerich. "Adaptation of cardiac and skeletal muscle mitochondria to endurance training: implications for cardiac protection." In Cardiac Adaptations, pp. 375-402. Springer New York, 2013. [33]. Higashi Y, Sukhanov S, Anwar A, Shai SY, Delafontaine P. “Aging, atherosclerosis, and IGF-1”, J Gerontol A Biol Sci Med Sci )2012(; 67(6):626-639. [34]. Li, Chun-Ying, Jae-Seon Lee, Young-Gyu Ko, Jong-Il Kim, and Jeong-Sun Seo. "Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation." Journal of Biological Chemistry 275, no. 33 (2000): 25665-25671. [35]. Beere, Helen M., Beni B. Wolf, Kelvin Cain, Dick D. Mosser, Artin Mahboubi, Tomomi Kuwana, Pankaj Tailor, Richard I. Morimoto, Gerald M. Cohen, and Douglas R. Green. "Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome." Nature cell biology, 2(8), (2000): 469-475. [36]. Reed, John C. "Apoptosis-regulating proteins as targets for drug discovery." Trends in molecular medicine, 7(7), (2001): 314-319. [37]. Radak, Zsolt, Shuzo Kumagai, Hideko Nakamoto, and Sataro Goto. "8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats." Journal of Applied Physiology, 102(4) (2007): 1696-1701. [38]. Huang, Chih-Yang, Ai-Lun Yang, Yueh-Min Lin, Fan-Ni Wu, James A. Lin, Yi-Sheng Chan, Fuu-Jen Tsai, Chang-Hai Tsai, Chia-Hua Kuo, and Shin-Da Lee. "Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts." Journal of applied physiology 112, no. 5 (2012): 883-891. [39]. Siu, Parco M., Randall W. Bryner, Julie K. Martyn, and Stephen E. Alway. "Apoptotic adaptations from exercise training in skeletal and cardiac muscles." The FASEB Journal, 18(10), (2004): 1150-1152. [40]. Quindry, John, Joel French, Karyn Hamilton, Youngil Lee, Jawahar L. Mehta, and Scott Powers. "Exercise training provides cardioprotection against ischemia–reperfusion induced apoptosis in young and old animals." Experimental gerontology, 40(5), (2005): 416- 425. [41]. Delchev, S., K. Georgieva, Y. Koeva, and P. Atanassova. "Bcl-2 and Bax Expression in Rat Myocardium after Acute Exercise and Endurance Training." In Proceeding of the Balkan Scientific Conference of Biology in Plovdiv (Bulgaria), pp. 19-21. )2005(. [42]. Kavazis A N, “Exercise preconditioning of the myocardium”. Sports Med 39(11), (2009) 923-935. [43]. Peterson, Jonathan M., Randall W. Bryner, Amy Sindler, Jefferson C. Frisbee, and Stephen E. Alway. "Mitochondrial apoptotic signaling is elevated in cardiac but not skeletal muscle in the obese Zucker rat and is reduced with aerobic exercise." Journal of applied physiology 105, no. 6 (2008): 1934 - 1943.‎ [44]. Cheng, Shiu-Min, Tsung-Jung Ho, Ai-Lun Yang, I-Ju Chen, Chung-Lan Kao, Fan-Ni Wu, James A. Lin et al. "Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats." International journal of cardiology 167, no. 2 (2013): 478-485. [45]. Lu, Kai, Li Wang, Changying Wang, Yuan Yang, Dayi Hu, and Rongjing Ding. "Effects of high-intensity interval versus continuous moderate‑intensity aerobic exercise on apoptosis, oxidative stress and metabolism of the infarcted myocardium in a rat model." Molecular medicine reports 12, no. 2 (2015): 2374-2382. [46]. Lee, S-D., W-C. Shyu, I-S. Cheng, C-H. Kuo, Y-S. Chan, Y-M. Lin, C-Y. Tasi, C-H. Tsai, T-J. Ho, and C-Y. Huang. "Effects of exercise training on cardiac apoptosis in obese rats." Nutrition, Metabolism and Cardiovascular Diseases 23, no. 6 (2013): 566-573. [47]. Choi, Jun-Ho, Tae-Soo Kim, Joon-Ki Park, Young-Je Sim, Kijeong Kim, and Sam-Jun Lee. "Short-term treadmill exercise preserves sensory-motor function through inhibiting apoptosis in the hippocampus of hypoxic ischemia injury rat pups." Journal of exercise rehabilitation, 9(5), (2013): 457. [48]. Santana, Eduardo Tadeu, Andrey Jorge Serra, José Antonio Silva Junior, Danilo Sales Bocalini, Valério Garrone Barauna, José Eduardo Krieger, and Paulo José Ferreira Tucci. "Aerobic exercise training induces an anti-apoptotic milieu in myocardial tissue." Motriz: Revista de Educação Física 20, no. 2 (2014): 233-238 [49]. Zhao, Y. C. "Effects of exercise training on myocardial mitochondrial miR-499-CaN-Drp-1 apoptotic pathway in mice." Zhongguo ying yong sheng li xue za zhi= Zhongguo yingyong shenglixue zazhi= Chinese journal of applied physiology, 31(3), (2015): 259-263. [50]. Doustar Y, Mohajeri D, Rezaei A, et al, "The effect of endurance swimming exercise on the occurrence of apoptosis in experimental diabetic myopathic rats", Journal of Islamic Azad Uni. Tabriz Branch. 3(4), (2010). 629-636. [51]. 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Tehran University Medical Journal TUMS Publications, 74(11), (2017): 807-816. [55]. Razavi Majd Z, Matin Homaee H, Azarbayjani MA, "Effects of Concurrent Regular Aerobic Training and Garlic Extract on Cardiac Tissue Apoptosis Markers in Aged Rats with Chronic Kidney Disease", Journal of Medicinal Plants. 2(62), (2017); 54-64. [56]. Zikaki, Kyriaki, Ioanna-Katerina Aggeli, Catherine Gaitanaki, and Isidoros Beis. "Curcumin induces the apoptotic intrinsic pathway via upregulation of reactive oxygen species and JNKs in H9c2 cardiac myoblasts." Apoptosis, 19(6), (2014): 958-974. [57]. Zhu, Lin, Ming Bao Han, Yuan Gao, Huan Wang, Ling Dai, Ying Wen, and Li Xin Na. "Curcumin triggers apoptosis via upregulation of Bax/Bcl-2 ratio and caspase activation in SW872 human adipocytes." Molecular medicine reports 12, no. 1 (2015): 1151-1156. [58]. El-Sayed, Eman M., Amal S. Abd El-azeem, Abeer A. Afify, Manal H. Shabana, and Hanaa H. Ahmed. 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Pourrazi H, Jafari A, Nikookheslat S, Baradaran B, “Effect of three-month aerobic training on some indices of myocardial apoptosis”, National Conference on Applied Science of Sport and Health, Tabriz, Iran,2015. [52]. Fattahi Bafghi, A., H.M. Homaee, and M.A. Azarbayjani, Effects of High Intensity Interval Training and Curcumin Supplement on Antioxidant Enzyme in Heart Tissue of Diabetic Rats. Iranian Journal of Diabetes and Obesity, 2016. 8(3): p. 135-141. [53]. Emami, A.-M., H.M. Homaee, and M.A. Azarbayjani, Effects of High Intensity Interval Training and Curcumin Supplement on Glutathione Peroxidase (GPX) Activity and Malondialdehyde (MDA) Concentration of the Liver in STZ Induced Diabetic Rats. Iranian Journal of Diabetes and Obesity, 2016. 8(3): p. 129-134. [54].Sadat Hoseini S.K, Dabidi Roshan VA, " The interactive effects of two forced and voluntary exercise training method and Nanocurcumin supplement on doxorubicin-induced hepatotoxicity in aging induced by D-galactos". Tehran University Medical Journal TUMS Publications, 74(11), (2017): 807-816. [55]. Razavi Majd Z, Matin Homaee H, Azarbayjani MA, "Effects of Concurrent Regular Aerobic Training and Garlic Extract on Cardiac Tissue Apoptosis Markers in Aged Rats with Chronic Kidney Disease", Journal of Medicinal Plants. 2(62), (2017); 54-64. [56]. Zikaki, Kyriaki, Ioanna-Katerina Aggeli, Catherine Gaitanaki, and Isidoros Beis. "Curcumin induces the apoptotic intrinsic pathway via upregulation of reactive oxygen species and JNKs in H9c2 cardiac myoblasts." Apoptosis, 19(6), (2014): 958-974. [57]. Zhu, Lin, Ming Bao Han, Yuan Gao, Huan Wang, Ling Dai, Ying Wen, and Li Xin Na. "Curcumin triggers apoptosis via upregulation of Bax/Bcl-2 ratio and caspase activation in SW872 human adipocytes." Molecular medicine reports 12, no. 1 (2015): 1151-1156. [58]. El-Sayed, Eman M., Amal S. Abd El-azeem, Abeer A. Afify, Manal H. Shabana, and Hanaa H. Ahmed. "Cardioprotective effects of Curcuma longa L. extracts against doxorubicin-induced cardiotoxicity in rats." Journal of Medicinal Plants Research, 5(17) (2011): 4049-4058. [59]. Sandri, Marco, Ugo Carraro, Marzena Podhorska-Okolov, Corrado Rizzi, Paola Arslan, Daniela Monti, and Claudio Franceschi. "Apoptosis, DNA damage and ubiquitin expression in normal and mdx muscle fibers after exercise." FEBS letters 373, no. 3 (1995): 291-295. [1]. Rajaei F, Rad JS, Niknafs B, et al. "Effect of vitrification on apoptosis in mouse blastocysts". J Reprod Infertil; 7: 14-22. (2004). [2]. Aggarwal BB, Surh YJ, Shihsodia S (Ed).: "The molecular targets and therapeutic uses of curcumin in health and disease". Adv Exp Med Biol 595; 8: (2007). [3]. Feizolahi F, Azarbayjani MA, Nasehi M, et al. "Comparison the Effect of Short-term Swimming Training and Curcumin Supplementation on Damaged Spatial Memory after Binge Ethanol Drinking in Male Rats: Preliminary Report". Journal of Medicinal Plants”, 16(10), 174-184, (2016). [4]. Moradi Kelardeh B, Azarbayjani MA, Peeri M, et al. "Effect of Curcumin Supplementation and Resistance Training in Patients with Nonalcoholic Fatty Liver Disease". Journal of Medicinal Plants. 15(60), 161-172, (2016). [5]. Geng, Hai-Hua, Rui Li, Ya-Min Su, Jie Xiao, Min Pan, Xing-Xing Cai, and Xiao-Ping Ji. "Curcumin protects cardiac myocyte against hypoxia-induced apoptosis through upregulating miR-7a/b expression." Biomedicine & Pharmacotherapy 81 (2016): 258-264. [6]. Marfe, Gabriella, Marco Tafani, Bruna Pucci, Carla Di Stefano, Manuela Indelicato, Angela Andreoli, Matteo Antonio Russo, Paola Sinibaldi-Salimei, and Vincenzo Manzi. "RETRACTED ARTICLE: The effect of marathon on mRNA expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners." BMC physiology 10, no. 1 (2010): 7. [7]. Ahmadiasl, Nasser, Farhad Ghadiri Soufi, Mohammadreza Alipour, Mohammadreza Bonyadi, Farzam Sheikhzadeh, Amirmansour Vatankhah, Iraj Salehi, and Mehran Mesgari. "Effects of age increment and 36-week exercise training on antioxidant enzymes and apoptosis in rat heart tissue." Journal of sports science & medicine 6, no. 2 (2007): 243. [8]. Amirkhani Z, Azarbayjani MA, MatinHomaee H, Pri M, “Effect of Combining Resistance Training and Curcumin Supplementation on Lipid Profile in Inactive Obese and Overweight Females”, Iranian Journal of Obstetrics, Gynecology and Infertility, 2017. [9]. Rezai SH, Matin homaee H, Azarbayjani MA. et al. " The Effect of Intense and Moderate Interval Aerobic Exercise and Curcumin Consumption on the Gene Expression of c-Kit in Stem Cells of Old Rats Heart". Journal of Fasa University of Medical Sciences. 6(1), (2016). [10]. Jafari A, Pourrazi H, Nikookheslat S, and Baradaran B. "Effect of Exercise Training on Bcl-2 and Bax Gene Expression in the Rat Heart." Gene, Cell and Tissue, 2(4), (2015). [11]. Jafari, M., Shirbazou, S., Sadraie, S.H., Kaka, G. and Norozi, M., 2015. The role of apoptosis in the cellular response of liver and spleen of BALB/c mice in cutaneous leishmaniasis. Iranian journal of medical sciences, 40(2), p.133. [12]. Suliman, Ayoub, Arh Lam, Rakesh Datta, and Rakesh K. Srivastava. "Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and-independent pathways." Oncogene 20, no. 17 (2001): 2122-2133. [13]. Kroemer, Guido. "Mitochondrial control of apoptosis: an introduction." Biochemical and biophysical research communications 304, no. 3 (2003): 433-435. [14]. KOSTANECKI, K., J. MIŁOBĘDZKA, and W. LAMPE. "Zur Kenntnis des Curcumins." Berichte der Deutschen Chemischen Gesellschaft 43, no. 2 (1910): 2163-2170. [15]. Wang, Yuehong, Jinjun Zhao, Wei Yang, Yayan Bi, Jing Chi, Juanjuan Tian, and Weimin Li. "High-dose alcohol induces reactive oxygen species-mediated apoptosis via PKC-β/p66Shc in mouse primary cardiomyocytes." Biochemical and biophysical research communications 456, no. 2 (2015): 656-661. [16]. Maheshwari, R.K.; Singh, A.K.; Gaddipati, J.; Srimal, R.C. “Multiple biological activities of curcumin: A short review”, Life Sci. )2006(, 78(18), 2081-2087. [17]. Yu, Linsheng, Yanyan Fan, Guanghua Ye, Junli Li, Xiangping Feng, Kezhi Lin, Miuwu Dong, and Zhenyuan Wang. "Curcumin inhibits apoptosis and brain edema induced by hypoxia-hypercapnia brain damage in rat models." The American journal of the medical sciences, 349(6), (2015): 521-525. [18]. Manna P., Das J., Ghosh J., Sil P.C. “Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid”, Free Radic Biol Med, )2010(, 48 (11):1465-84. [19]. Tao, Pei, Haiyan Yin, and Yonghui Ma. "Study of the mechanisms of curcumin on mitochondrial permeability transition of hepatocytes in rats with sepsis." Zhonghua wei zhong bing ji jiu yi xue 26, no. 9 (2014): 666-670. [20]. Somasundaram, Sivagurunathan, Natalie A. Edmund, Dominic T. Moore, George W. Small, Yue Y. Shi, and Robert Z. Orlowski. "Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer." Cancer research 62, no. 13 (2002): 3868-3875. [21]. Ghoneim, Asser I. "Effects of curcumin on ethanol-induced hepatocyte necrosis and apoptosis: implication of lipid peroxidation and cytochrome c." Naunyn-Schmiedeberg's archives of pharmacology, 379(1), (2009): 47-60. [22]. Samuhasaneeto, Suchittra, Duangporn Thong-Ngam, Onanong Kulaputana, Doungsamon Suyasunanont, and Naruemon Klaikeaw. "Curcumin Decreased Oxidative Stress, Inhibited NF-𝜅 B Activation, and Improved Liver Pathology in Ethanol-Induced Liver Injury in Rats." BioMed Research International, (2009). [23]. Tiwari, Vinod, and Kanwaljit Chopra. "Attenuation of oxidative stress, neuroinflammation, and apoptosis by curcumin prevents cognitive deficits in rats postnatally exposed to ethanol." Psychopharmacology (2012): 1-17. [24]. Bulku, Elida, Sidney J Stohs, Lorraine Cicero, Tracy Brooks, Herb Halley, and Sidhartha D Ray. "Curcumin exposure modulates multiple pro-apoptotic and anti-apoptotic signaling pathways to antagonize acetaminophen-induced toxicity." Current neurovascular research 9, no. 1 (2012): 58-71. [25]. Wang, Long. "Curcumin prevents the non-alcoholic fatty hepatitis via mitochondria protection and apoptosis reduction." International journal of clinical and experimental pathology 8, no. 9 (2015): 11503. [26]. Motaghinejad, Majid, Morteza Karimian, Ozra Motaghinejad, Behnaz Shabab, Iraj Yazdani, and Sulail Fatima. "Protective effects of various dosage of Curcumin against morphine induced apoptosis and oxidative stress in rat isolated hippocampus." 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