Jahrom University of Medical Sciences Pars Journal of Medical Sciences 2717-0284 23 1 2025 05 22 The effect of two months of high intensity interval training and vitamin D intake on the serum concentration of Adiponectin and Interleukin 6 in overweight women with vitamin D deficiency The effect of two months of high intensity interval training and vitamin D intake on the serum concentration of Adiponectin and Interleukin 6 in overweight women with vitamin D deficiency 20 29 725304 10.22034/pjms.2025.2060152.1207 FA Parvaneh Safari Master's Degree, Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran Negar Mohammadi Master's Degree, Department of Physical Education and Sport Sciences, Sari Branch, Islamic Azad University, Sari, Iran 0009-0006-1354-2249 Masoumeh Habibian Associate Professor, Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran 0000-0003-1028-1726 Journal Article 2025 05 09 Introduction: Obesity and low serum vitaminD (VitD) levels are important risk factors for chronic systemic inflammation, and an inactive lifestyle contributes to the enhancement of these factors. This study aimed to investigate the effect of two months of high intensity interval resistance training and VitD on the serum concentratio Materials and Methods n of adiponectin and interleukin-6 (IL-6) in women with VitD deficiency.<br>Materials and Methods: In this study, 52overweight and VitD deficient women were selected through convenience and purposive sampling and then randomly divided into control, exercise, VitD, and combination groups. The exercise program consisted of 5 exercises in three sets (6 repetitions/set, with an intensity of 80% of one repetition maximum with20 seconds of rest) and 3 sessions/week. VitD was consumed weekly with a dose of 50,000 units. One-way analysis of variance and Kruskal-Wallis tests were used to analyze the data.<br>Results: All three interventions led to a significant increase in adiponectin concentration and a significant decrease in IL-6 (P<0.001). The effect of exercise in reducing IL-6 and increasing adiponectin was greater compared to VitD consumption(P<0.001). But the combined intervention had significant synergistic effects in the changes of these variables compared to the other two interventions(P<0.001).<br>Conclusion: It seems that high intensity interval resistance training, VitD consumption and combined intervention can help reduce systemic inflammation in overweight conditions with VitD deficiency partially by reducing the inflammatory index of IL-6 and increasing adiponectin. Although the combined intervention has been associated with stronger effects in the changes of these variables. Introduction: Obesity and low serum vitaminD (VitD) levels are important risk factors for chronic systemic inflammation, and an inactive lifestyle contributes to the enhancement of these factors. This study aimed to investigate the effect of two months of high intensity interval resistance training and VitD on the serum concentratio Materials and Methods n of adiponectin and interleukin-6 (IL-6) in women with VitD deficiency.<br>Materials and Methods: In this study, 52overweight and VitD deficient women were selected through convenience and purposive sampling and then randomly divided into control, exercise, VitD, and combination groups. The exercise program consisted of 5 exercises in three sets (6 repetitions/set, with an intensity of 80% of one repetition maximum with20 seconds of rest) and 3 sessions/week. VitD was consumed weekly with a dose of 50,000 units. One-way analysis of variance and Kruskal-Wallis tests were used to analyze the data.<br>Results: All three interventions led to a significant increase in adiponectin concentration and a significant decrease in IL-6 (P<0.001). The effect of exercise in reducing IL-6 and increasing adiponectin was greater compared to VitD consumption(P<0.001). But the combined intervention had significant synergistic effects in the changes of these variables compared to the other two interventions(P<0.001).<br>Conclusion: It seems that high intensity interval resistance training, VitD consumption and combined intervention can help reduce systemic inflammation in overweight conditions with VitD deficiency partially by reducing the inflammatory index of IL-6 and increasing adiponectin. Although the combined intervention has been associated with stronger effects in the changes of these variables. https://jmj.jums.ac.ir/article_725304_7b65e7a7cfe486cada433cdf57e72e5d.pdf