Jahrom University of Medical Sciences Pars Journal of Medical Sciences 2717-0284 22 3 2024 11 21 The effect of leech therapy on the severity and extent of psoriasis: a randomized, blinded clinical trial The effect of leech therapy on the severity and extent of psoriasis: a randomized, blinded clinical trial 56 62 718320 10.22034/pjms.2024.2042595.1171 FA Mohsen Fasele . Assistant Professor, Faculty of Nursing, Jahrom University of Medical Sciences, Jahrom, Iran Ehsan Khavare Master of Science in Nursing, Faculty of Nursing, Jahrom University of Medical Sciences, Jahrom, Iran Mohsen Hojat Assistant Professor, Faculty of Nursing, Jahrom University of Medical Sciences, Jahrom, Iran 0000-0003-2446-6035 Journal Article 2024 10 05 Introduction: Today, three to eleven percent of the world's population is suffering from psoriasis. This disease causes many physical, psychological, and social complications for patients. Despite the high cost and time of treating this chronic disease, modern medicine has not yet been able to provide a definitive solution for its treatment, however, in most of the old Greek, Iranian, and Indian medical books, complementary medicine and especially leech therapy are introduced as one of the ways to treat this disease. The present study was designed and implemented to determine the effectiveness of leech therapy on the severity and extent of psoriasis.<br />Materials & Methods: This randomized, blinded, controlled clinical trial was conducted on 60 patients. Patients were randomly assigned to two intervention groups (routine psoriasis care with leech therapy) and control (receiving routine psoriasis care). The data collection tool included a demographic information questionnaire and the Psoriasis Extent and Severity Index (PASI). Data were analyzed with the help of the spss22 program under Windows and using Kolmogorov Smirnov, independent t, chisquare, and paired t-test.<br />Results: The majority of the patients were men and held a diploma or higher degree. Before the intervention, the background variables and average PASI scores in the two groups did not have statistically significant differences (P=0.83, t=0.26). After the intervention, the mean score of PASI in the two intervention groups was statistically significantly different from the control group (P=0.004, t=2.94). In the two measurement periods (before and after the intervention), the mean scores of the PASI index in intervention group and in control group had a statistically significant difference.<br />Conclusion: The implementation of leech therapy is effective in improving the symptoms of psoriasis patients and results in a significant decrease in the PASI score of patients undergoing leech therapy, therefore, leech therapy as a cost-effective method in terms of cost and time can be used alongside Common medical treatments help in the recovery of such patients. Introduction: Today, three to eleven percent of the world's population is suffering from psoriasis. This disease causes many physical, psychological, and social complications for patients. Despite the high cost and time of treating this chronic disease, modern medicine has not yet been able to provide a definitive solution for its treatment, however, in most of the old Greek, Iranian, and Indian medical books, complementary medicine and especially leech therapy are introduced as one of the ways to treat this disease. The present study was designed and implemented to determine the effectiveness of leech therapy on the severity and extent of psoriasis.<br />Materials & Methods: This randomized, blinded, controlled clinical trial was conducted on 60 patients. Patients were randomly assigned to two intervention groups (routine psoriasis care with leech therapy) and control (receiving routine psoriasis care). The data collection tool included a demographic information questionnaire and the Psoriasis Extent and Severity Index (PASI). Data were analyzed with the help of the spss22 program under Windows and using Kolmogorov Smirnov, independent t, chisquare, and paired t-test.<br />Results: The majority of the patients were men and held a diploma or higher degree. Before the intervention, the background variables and average PASI scores in the two groups did not have statistically significant differences (P=0.83, t=0.26). After the intervention, the mean score of PASI in the two intervention groups was statistically significantly different from the control group (P=0.004, t=2.94). In the two measurement periods (before and after the intervention), the mean scores of the PASI index in intervention group and in control group had a statistically significant difference.<br />Conclusion: The implementation of leech therapy is effective in improving the symptoms of psoriasis patients and results in a significant decrease in the PASI score of patients undergoing leech therapy, therefore, leech therapy as a cost-effective method in terms of cost and time can be used alongside Common medical treatments help in the recovery of such patients. https://jmj.jums.ac.ir/article_718320_8784c177c8324ce2dd60821a9d5d5774.pdf