Jahrom University of Medical Sciences Pars Journal of Medical Sciences 2717-0284 22 3 2024 11 21 Evaluation of hematological changes in critically ill COVID- 19 patients with venous thromboembolism Evaluation of hematological changes in critically ill COVID- 19 patients with venous thromboembolism 30 36 718317 10.22034/pjms.2024.2031137.1142 FA Akbar Hashemi Tayer Research Center for Noncommunicable Diseases , Jahrom University of Medical Sciences, Jahrom, Iran 0000-0001-8007-5552 Maryam Kamravan Research Center for Noncommunicable Diseases , Jahrom University of Medical Sciences, Jahrom, Iran 0000-0003-3574-6753 Mohadeseh Moradiparast Research Center for Noncommunicable Diseases , Jahrom University of Medical Sciences, Jahrom, Iran Journal Article 2024 06 04 Introduction: The COVID-19 disease significantly impacts the blood coagulation system. Some patients with a severe form of COVID-19 are more susceptible to coagulation disorders, disseminated  intravascular coagulation (DIC), and severe inflammatory responses. This study seeks to improve our understanding of coagulation parameters and examine their changes in COVID-19 patients with venous thromboembolism (VTE).<br />Materials and Methods: In this case-control study, 56 patients with COVID-19 were admitted to the intensive care unit, consisting of 30 patients without venous thromboembolism (VTE) and 26 patients with VTE. Additionally, 30 healthy individuals who provided written informed consent were included in the sampling. Complete blood count (CBC) was conducted using a sysmax hematology analyzer. Prothrombin time (PT), partial thromboplastin time (PTT), and fibrinogen tests were manually performed with dual repeat for clot formation evaluation. Furthermore, d-dimer, and vWF-Ag indices<br />were determined using the ELISA-based technique.<br />Results: In the analysis of CBC parameters, a statistically significant difference was noted between critically ill patients with COVID-19 and healthy individuals (p<0.001). There was also a substantial elevation in coagulation panels, fibrinogen, and D-dimer levels in COVID-19 patients with VTE compared to those without VTE and healthy individuals (p<0.001).<br />Conclusion: COVID-19 patients, particularly those with VTE, exhibit notable variations in blood and coagulation parameters, as well as increased fibrinogen levels, indicating a potential augmentation in the susceptibility to thrombotic events. Introduction: The COVID-19 disease significantly impacts the blood coagulation system. Some patients with a severe form of COVID-19 are more susceptible to coagulation disorders, disseminated  intravascular coagulation (DIC), and severe inflammatory responses. This study seeks to improve our understanding of coagulation parameters and examine their changes in COVID-19 patients with venous thromboembolism (VTE).<br />Materials and Methods: In this case-control study, 56 patients with COVID-19 were admitted to the intensive care unit, consisting of 30 patients without venous thromboembolism (VTE) and 26 patients with VTE. Additionally, 30 healthy individuals who provided written informed consent were included in the sampling. Complete blood count (CBC) was conducted using a sysmax hematology analyzer. Prothrombin time (PT), partial thromboplastin time (PTT), and fibrinogen tests were manually performed with dual repeat for clot formation evaluation. Furthermore, d-dimer, and vWF-Ag indices<br />were determined using the ELISA-based technique.<br />Results: In the analysis of CBC parameters, a statistically significant difference was noted between critically ill patients with COVID-19 and healthy individuals (p<0.001). There was also a substantial elevation in coagulation panels, fibrinogen, and D-dimer levels in COVID-19 patients with VTE compared to those without VTE and healthy individuals (p<0.001).<br />Conclusion: COVID-19 patients, particularly those with VTE, exhibit notable variations in blood and coagulation parameters, as well as increased fibrinogen levels, indicating a potential augmentation in the susceptibility to thrombotic events. https://jmj.jums.ac.ir/article_718317_1fcc93472a88752b61cfbfc29227a4aa.pdf