Jahrom University of Medical Sciences Pars Journal of Medical Sciences 2717-0284 20 4 2023 02 20 Studying the effect of lycopene on serum concentrations of leptin, cholecystokinin, neuropeptide Y, and body weight changes in adult female rats Studying the effect of lycopene on serum concentrations of leptin, cholecystokinin, neuropeptide Y, and body weight changes in adult female rats 65 70 701650 10.22034/pjms.2023.701650 FA Maliha Hajiani Research center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran Shekoufeh Atashpour Department of Pharmacology, Jahrom University of Medical Sciences, Jahrom, Iran Marzieh Rahimipour Department of Anatomical Sciences, Jahrom University of Medical Sciences, Jahrom, Iran 0000-0003-2870-1119 Yaser Sarikhani Research center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran 0000-0002-0615-9210 Jila Rahmanian Research center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran 0000-0002-1338-5662 Shiva Saleh Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran 0000-0003-2628-2096 Hamidreza Dowlatkhah Research center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran Hossein Kargar Jahromi Research center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran 0000-0002-2614-8885 Journal Article 2022 01 12 Introduction: Lycopene is a lipophilic carotenoid found in high quantities in tomatoes. The aim of this study was to<br />investigate the effects of lycopene on serum concentrations of leptin, cholecystokinin, neuropeptide Y, and body weight changes in adult female rats.<br />Methods & Materials: In this experimental study, 32 adult female Wistar rats were divided into four groups of eight including control, Sham, and two experimental groups receiving lycopene (at concentrations of five and 10 mg/kg). Lycopene was administered to the animals by gavage. Twenty-nine days after the start of the experiment and after weighing the animals, blood samples were taken from heart and serum concentrations of cholecystokinin, leptin, and neuropeptide Y were measured. Results were analyzed using ANOVA statistical test and Duncan's test at significance level of p≤0.05.<br />Results: Lycopene at concentration of 10 mg/kg significantly increased leptin (4.01±0.62) and cholecystokinin (1158.62±65.68) while significantly reduced neuropeptide Y (138.05±26.09) and body weight (21.12±2.10) compared to the control group (leptin: 3.07±0.47/ cholecystokinin: 925±158.55/ neuropeptide Y: 200.45±26.55/ body weight: 24.50±2.82) (P<0.05).<br />Conclusion: Lycopene reduces body weight by increasing serum levels of appetite-reducing hormones (leptin and<br />cholecystokinin) and inhibition of orexigenic neuropeptide Y hormone. Introduction: Lycopene is a lipophilic carotenoid found in high quantities in tomatoes. The aim of this study was to<br />investigate the effects of lycopene on serum concentrations of leptin, cholecystokinin, neuropeptide Y, and body weight changes in adult female rats.<br />Methods & Materials: In this experimental study, 32 adult female Wistar rats were divided into four groups of eight including control, Sham, and two experimental groups receiving lycopene (at concentrations of five and 10 mg/kg). Lycopene was administered to the animals by gavage. Twenty-nine days after the start of the experiment and after weighing the animals, blood samples were taken from heart and serum concentrations of cholecystokinin, leptin, and neuropeptide Y were measured. Results were analyzed using ANOVA statistical test and Duncan's test at significance level of p≤0.05.<br />Results: Lycopene at concentration of 10 mg/kg significantly increased leptin (4.01±0.62) and cholecystokinin (1158.62±65.68) while significantly reduced neuropeptide Y (138.05±26.09) and body weight (21.12±2.10) compared to the control group (leptin: 3.07±0.47/ cholecystokinin: 925±158.55/ neuropeptide Y: 200.45±26.55/ body weight: 24.50±2.82) (P<0.05).<br />Conclusion: Lycopene reduces body weight by increasing serum levels of appetite-reducing hormones (leptin and<br />cholecystokinin) and inhibition of orexigenic neuropeptide Y hormone. https://jmj.jums.ac.ir/article_701650_adb60b19484ee50ec407af43a1be9fb7.pdf