Jahrom University of Medical Sciences Pars Journal of Medical Sciences 2717-0284 17 1 2022 12 25 The effect of twelve weeks aerobic training with Rose damascena supplementation on expression of Caspase 3 and 9 genes of Soleus muscle in male rats The effect of twelve weeks aerobic training with Rose damascena supplementation on expression of Caspase 3 and 9 genes of Soleus muscle in male rats 42 51 700409 10.52547/jmj.17.1.42 FA Fatemeh Ghased Tabriz Branch, Islamic Azad University, Tabriz, Iran 0000-0002-4565-7052 Jabbar Bashiri Tabriz Branch, Islamic Azad University, Tabriz, Iran Journal Article 2022 12 25 Introduction: Caspases play an important role in the cellular death process and, on the other hand, Rose has protective effects in this area. The purpose of this study was to investigate the effect of aerobic exercises with Rose damascena supplementation on the expression of caspase 3 and 9 genes of soleus muscle in male rats.<br />Materials and Methods: In this experimental study, 50 male Wistar, two-month-old rats were randomly divided into five<br />groups (three-month control, six-month control, exercise, Rose damascena, and combined). Aerobic exercise and aerobic exercises + Rose participated in the treadmill on a gradient of 15% for 5 days a week and for 12 weeks, and the Rose damascena and combined groups received 0.09 grams of rose + 9 cc saline per kg body weight with gavage,. After intervention aerobic exercises and use of Rose damascena, surgical procedures and extraction of specimens were performed in rats. The data were analyzed by ANOVA at a significant level of less than 0.05.<br />Results: Caspase 3 and 9 genes expression in soleus muscles of aerobic exercise and rose damascena and combaind group (rose and aerobic exercise) was less pronounced than in six-month control group, respectively, so that in 6 month control group the highest expression was observed.<br />Conclusion: According to the results, aerobic exercises and Rose damascena maybe can reduce the rate of cell<br />apoptosis by reducing the expression of Caspase 3 and 9 genes, and slow down the muscle weakness. Introduction: Caspases play an important role in the cellular death process and, on the other hand, Rose has protective effects in this area. The purpose of this study was to investigate the effect of aerobic exercises with Rose damascena supplementation on the expression of caspase 3 and 9 genes of soleus muscle in male rats.<br />Materials and Methods: In this experimental study, 50 male Wistar, two-month-old rats were randomly divided into five<br />groups (three-month control, six-month control, exercise, Rose damascena, and combined). Aerobic exercise and aerobic exercises + Rose participated in the treadmill on a gradient of 15% for 5 days a week and for 12 weeks, and the Rose damascena and combined groups received 0.09 grams of rose + 9 cc saline per kg body weight with gavage,. After intervention aerobic exercises and use of Rose damascena, surgical procedures and extraction of specimens were performed in rats. The data were analyzed by ANOVA at a significant level of less than 0.05.<br />Results: Caspase 3 and 9 genes expression in soleus muscles of aerobic exercise and rose damascena and combaind group (rose and aerobic exercise) was less pronounced than in six-month control group, respectively, so that in 6 month control group the highest expression was observed.<br />Conclusion: According to the results, aerobic exercises and Rose damascena maybe can reduce the rate of cell<br />apoptosis by reducing the expression of Caspase 3 and 9 genes, and slow down the muscle weakness. https://jmj.jums.ac.ir/article_700409_7e2eff139e3e7efed7e4fd1968251530.pdf