Jahrom University of Medical Sciences Pars Journal of Medical Sciences 2717-0284 16 4 2022 12 25 Aerobic exercises and Supplement Spirulina reduce inflammation in diabetic men Aerobic exercises and Supplement Spirulina reduce inflammation in diabetic men 10 18 700397 10.52547/jmj.16.4.10 FA Babak Hooshmand Moghadam PhD student, Department of Physiology and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran 0000-0002-2036-9492 Mohamad Reza Kordi Associate Professor of Physiology and Sport Sciences, University of Tehran, Tehran, Iran 0000-0002-6796-1696 Seyyed Reza Attarzade Hosseini Professor of Physiology and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran 0000-0002-9059-3262 Taymaz Davaloo MSc, Department of Physiology and Sport Sciences, University of Tehran, Tehran, Iran Journal Article 2022 12 25 Introduction: The use of exercise and herbal supplements for the treatment of metabolic diseases and disorders among the population has increased. Spirulina (Herbal Supplement green algae – blue) is one of the richest sources of Anti-inflammatory and antioxidants. Thus, the purpose of this study was to investigate the effect of 8-week exercise with Spirulina consumption on Inflammatory markers tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) in men with type 2 diabetes. Materials & Methods: 32 sedentary men with type 2 diabetes participated in this study with average age of 40 years and with no history of regular exercise that were randomly divided into 4 groups: control (C), exercise (E), supplementation (S) and exercise + supplementation (E+S). Training programs were 45 minutes of aerobic exercise, 3 times in week with 60-65% of maximal heart rate. S and E+S groups consumed Daily 2 tablets of 500 mg Spirulina. Blood samples were taken in two phases (before and after 8 weeks) following 10 to 12 hours of being fasted. Results: TNF-α, IL-6 and CRP levels Decreased significantly in E, S, E+S groups after 8 weeks (P ≤ 0/05).If these changes were not significant in the control group. Also The results showed there was a significant differences between the effects of different interventions in the TNF-α, IL-6 and CRP between groups with the control group (P ≤ 0/05). Conclusions: The results showed that regular aerobic exercise with Spirulina consumption can improve Serum levels of inflammatory markers in men with type 2 diabetes and prevent exercise-induced Inflammation stress and also diabetes. Introduction: The use of exercise and herbal supplements for the treatment of metabolic diseases and disorders among the population has increased. Spirulina (Herbal Supplement green algae – blue) is one of the richest sources of Anti-inflammatory and antioxidants. Thus, the purpose of this study was to investigate the effect of 8-week exercise with Spirulina consumption on Inflammatory markers tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) in men with type 2 diabetes. Materials & Methods: 32 sedentary men with type 2 diabetes participated in this study with average age of 40 years and with no history of regular exercise that were randomly divided into 4 groups: control (C), exercise (E), supplementation (S) and exercise + supplementation (E+S). Training programs were 45 minutes of aerobic exercise, 3 times in week with 60-65% of maximal heart rate. S and E+S groups consumed Daily 2 tablets of 500 mg Spirulina. Blood samples were taken in two phases (before and after 8 weeks) following 10 to 12 hours of being fasted. Results: TNF-α, IL-6 and CRP levels Decreased significantly in E, S, E+S groups after 8 weeks (P ≤ 0/05).If these changes were not significant in the control group. Also The results showed there was a significant differences between the effects of different interventions in the TNF-α, IL-6 and CRP between groups with the control group (P ≤ 0/05). Conclusions: The results showed that regular aerobic exercise with Spirulina consumption can improve Serum levels of inflammatory markers in men with type 2 diabetes and prevent exercise-induced Inflammation stress and also diabetes.

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