Jahrom University of Medical Sciences Pars Journal of Medical Sciences 2717-0284 15 3 2022 12 25 Effect of the combination of soy milk and physical activity on serum ‎myogenin changes of sedentary aged women ‎ Effect of the combination of soy milk and physical activity on serum ‎myogenin changes of sedentary aged women ‎ 34 41 700365 10.52547/jmj.15.3.6 FA Rahman Soori 0000-0001-5264-3751 Sirous Choobineh 0000-0001-5264-3751 Sahabeh Mahdian 0000-0001-5264-3751 Mahsa Rastegar MM 0000-0001-5264-3751 Journal Article 2022 12 25 Background: Aging is multidimensional process that affiliated with deterioration of the neuromuscular function and major variations in hypertrophic hormones such as myogenin. Different exercise and nutrition interventions clue to decelerate the muscle wasting. So, the aim of this study is to assess serum myogenin changes of sedentary aged women in response to physical activity and protein supplementation. Methods: The study was quasi-experimental designs and 24 aged subjects with the 70.32 ± 3.30 years old were chosen. Subjects were randomly divided into: control (n=8), physical activity-soy milk (n=8), and soy milk (n=8) and took part in exercise-diet intervention for 12 weeks (3 day/week). Anthropometrics, core body function, and myogenin levels were assess pre- and post-interventions. All data was analyzed by two way ANOVA and Bonferroni post-hoc on the p<0.05. Findings: Myogenin levels of both physical activity-soy milk and soy milk groups significantly increased compare with control and pre-intervention (p<0.05). Also, core body function significantly improved in some items in only physical activity-soy milk group compare with control and pre-intervention (p<0.05). Anthropometric features of aged women did not significantly change in any groups (p>0.05). Conclusion: Twelve weeks of exercise and nutrition interventions had similar effects on the myogenin elevation. Protein ingestion although couldn’t improve the elderly function in the current study, but we could anticipate that long-term myogenin elevation may improve muscle strength and function of elderly.   Background: Aging is multidimensional process that affiliated with deterioration of the neuromuscular function and major variations in hypertrophic hormones such as myogenin. Different exercise and nutrition interventions clue to decelerate the muscle wasting. So, the aim of this study is to assess serum myogenin changes of sedentary aged women in response to physical activity and protein supplementation. Methods: The study was quasi-experimental designs and 24 aged subjects with the 70.32 ± 3.30 years old were chosen. Subjects were randomly divided into: control (n=8), physical activity-soy milk (n=8), and soy milk (n=8) and took part in exercise-diet intervention for 12 weeks (3 day/week). Anthropometrics, core body function, and myogenin levels were assess pre- and post-interventions. All data was analyzed by two way ANOVA and Bonferroni post-hoc on the p<0.05. Findings: Myogenin levels of both physical activity-soy milk and soy milk groups significantly increased compare with control and pre-intervention (p<0.05). Also, core body function significantly improved in some items in only physical activity-soy milk group compare with control and pre-intervention (p<0.05). Anthropometric features of aged women did not significantly change in any groups (p>0.05). Conclusion: Twelve weeks of exercise and nutrition interventions had similar effects on the myogenin elevation. Protein ingestion although couldn’t improve the elderly function in the current study, but we could anticipate that long-term myogenin elevation may improve muscle strength and function of elderly.   https://jmj.jums.ac.ir/article_700365_ffbbdc3b6df163ef29d40c0752a5c28c.pdf