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:: Volume 5, Issue 1 And 2 (spring & summer 2007) ::
jmj 2007, 5(1 And 2): 21-26 Back to browse issues page
C3 and C4 in Women with Recurrent Pregnancy Loss
Reza Sotoodeh Jahromi *
Abstract:   (3897 Views)

Introduction: Fetal loss and recurrent abortion are responsible for significant emotional distress for couples desiring children. Regarding the etiologic importance, this study has been carried out to determine the serum level of C3 and C4 in women with recurrent miscarriage.

Material and Methods: This study was carried out in Shariatee hospital of Bandar Abbas university of medical sciences, during 2000 - 2001. 109 women with definite diagnosis of recurrent abortion or fetal loss as patients and 220 matched women with at least two successful deliveries and negative history of miscarriage as controls were studied. The sera of the patients and the controls were tested by SRID method for determining C3 and C4.

Results: Prevalence of reduced serum levels of C3 and C4 in the patients and the controls were 22.02% and 5% respectively and prevalence of reduced serum levels of C4 in the patients and the controls were 24.77% and 8.18% respectively. There was a significant difference between prevalence of reduced serum level of C3 and C4 in the patients and the controls (P < 0. 001).

 Conclusion: The results of this study suggest that complement system   plays a significant role in recurrent miscarriage. Further studies are needed to explore the role of Immune system -classical pathway of complement system- in fetal loss and spontaneous abortion.

Keywords: Recurrent miscarriage, Abortion, Complement system
Full-Text [PDF 1747 kb]   (1006 Downloads)    
Type of Study: Research | Subject: ect
Received: 2016/06/18 | Revised: 2018/03/4 | Accepted: 2016/06/18
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Sotoodeh Jahromi R. C3 and C4 in Women with Recurrent Pregnancy Loss. jmj 2007; 5 (1 and 2) :21-26
URL: http://jmj.jums.ac.ir/article-1-796-en.html


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Volume 5, Issue 1 And 2 (spring & summer 2007) Back to browse issues page
فصلنامه دانشگاه علوم پزشکی جهرم Journal of Jahrom University of Medical Sciences
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