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:: Volume 9, Issue 1 (spring2010 2011) ::
jjums 2011, 9(1): 23-27 Back to browse issues page
A survey and comparison of ET-1 level in scleroderma patients with and without pitting ulcer
Mardad Aghaei , Farhad Gharibdost , Habib Zayeni , Masoomeh Akhlaghi , Sima Sedighi , Abdalrahman Rostamian , Naser Aghdami , Mahdeyeh Shojaa
Abstract:   (6023 Views)

Introduction: Scleroderma is a systemic disorder with unknown etiology most notably characterized by skin thickening and damage of organs. Endothelin-1(ET-1) plays a role in skin fibrosis. This study aimed to survey and compareET-1level in systematic sclerosis (SSc) patients with and without scar pitting ulcer. Material and Methods: A cross-sectional analytical study was conducted on 95 patients with scleroderma in 2006 who were referred to the Rheumatology Clinic in Shariati hospital of Tehran. A questionnaire was completed and then the level of endothelin-1was measured in them. The data were analyzed using SPSS software and statistical tests. Results: The results indicated that the relationship among pitting ulcer, ulcer scar and the level of Endothelin-1 was significant. There was no significant relationship between age and the level of Endothelin-1. Conclusion: These data indicated that the Endothelin-1 plasma level in scleroderma patients with pitting ulcer was higher than patients without pitting ulcer. Thus, increase of ET-1 plasma level could be effective in vascular damage, fibrosis and skin thickness.

Keywords: Systemic Scleroderma, Endothelin-1, Ulcer
Full-Text [PDF 149 kb]   (667 Downloads)    
Type of Study: Research |
Received: 2014/05/12 | Accepted: 2014/05/12 | Published: 2014/05/12
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Aghaei M, Gharibdost F, Zayeni H, Akhlaghi M, Sedighi S, Rostamian A, et al . A survey and comparison of ET-1 level in scleroderma patients with and without pitting ulcer. jjums. 2011; 9 (1) :23-27
URL: http://jmj.jums.ac.ir/article-1-340-en.html


Volume 9, Issue 1 (spring2010 2011) Back to browse issues page
فصلنامه دانشگاه علوم پزشکی جهرم Journal of Jahrom University of Medical Sciences
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