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:: Volume 11, Issue 3 (fall 2013 2013) ::
jmj 2013, 11(3): 1-9 Back to browse issues page
Anti-inflammatory and anti-nociceptive effects of hydroalchoholic extract of Nepeta menthoides on pain in aerial parts in male mice
Sosan Asadi Balsin Sharif Abadi1 , Sima Nasri , Gholamreza Amin , Sayeh Bidaran
Abstract:   (5835 Views)
Introduction: The application of herbal plants instead of synthetic drugs has been increasing in recent years because of their lower side-effects and high varieties of efficient components. An investigation on anti-nociceptive and anti-inflammatory effects of hydroalcoholic extract of Nepeta menthoides seems to be necessary due to the existence of its components. Materials and Methods: This study was done on 224 NMRI male mice weighing 20-25 g. Xylene-induced ear edema and Formalin test were used for demonstrating its anti-inflammatory and anti-nociceptive effects. Results: The hydroalcholic extract had no toxic effect. This study showed that Nepeta menthoides aerial parts have anti-inflammatory effect at all doses, particularly at dose of 2800 mg/kg and significantly decreased nociception in chronic phases. The dose of 2800 mg/kg had the most anti-nociceptive effect in chronic phases. Meanwhile, in the immersion test, nociception decreased at a dose of 1400 mg/kg significantly. Conclusion: Hydroalcoholic extract of Nepeta menthoides has anti-nociceptive and anti-inflammatory effects. These effects might be due to its Nepetalactone and 1,8 cineole components.
Keywords: Analgesics, Plant Extracts, Mice
Full-Text [PDF 361 kb]   (1470 Downloads)    
Type of Study: Research |
Received: 2013/12/10 | Accepted: 2013/12/10 | Published: 2013/12/10
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Asadi Balsin Sharif Abadi1 S, Nasri S, Amin G, Bidaran S. Anti-inflammatory and anti-nociceptive effects of hydroalchoholic extract of Nepeta menthoides on pain in aerial parts in male mice. jmj. 2013; 11 (3) :1-9
URL: http://jmj.jums.ac.ir/article-1-252-en.html


Volume 11, Issue 3 (fall 2013 2013) Back to browse issues page
فصلنامه دانشگاه علوم پزشکی جهرم Journal of Jahrom University of Medical Sciences
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