:: Volume 17, Issue 2 (summer 2019) ::
jmj 2019, 17(2): 54-63 Back to browse issues page
Protective effect of melatonin on pituitary- gonadal axis hormones and spermatogenesis in sertraline-induced adult Balb/c mice
Mahmoud Goudarzi , Aliasghar Pilehvarian , Akbar Karimi
Biology Department, Payame Noor University, 19395_4697 Tehran, I.R.Iran
Abstract:   (592 Views)
Background and objective: Sertraline affects sexual function and fertility. Melatonin is a powerful antioxidant with the ability to neutralize medical toxins. The present study was an attempt to investigate the effects of melatonin on tissue changes and pituitary- gonadal axis changes occurring in in Balb/c rats following sertraline induction.
Materials and Methods: 40 male Balb / c mice were randomly assigned into 5 groups: control group (receiving sertraline at dose of 50 mg/kg body weight per day for two weeks) and experimental groups 1, 2 and 3 in which Melatonin was intraperitoneally administered at 5, 10 and 15 mg/kg body weight respectively). The experimental groups received melatonin and sertraline every other day and every day for 2 weeks, respectively. 15 days later, gonadal hormone were assessed through direct cardiac blood sampling and testicular histology.
Results: Sertraline-receiving rats, compared to the control group rats, showed a significant decrease in the levels of testosterone, FSH and LH (P˂0/01) and spermatogenesis (P˂0/001) compared to the control group. In experimental groups 2 and 3, Melatonin improved the adverse effects of sertraline on hormones (P˂0/01), gonadal tissue and spermatogenesis maturation process (P˂0/05).
Conclusion: Dose-dependent Melatonin administration can reduce the sertraline-induced effects on the mean serum levels of gonadal hormones and the number of spermatogenic lineage cells in Balb /c male mice.
 
Keywords: Melatonin, Testis, Sertraline, Infertility, Balb / c mice
Full-Text [PDF 744 kb]   (51 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2019/06/2 | Accepted: 2020/01/25 | Published: 2019/10/26


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Volume 17, Issue 2 (summer 2019) Back to browse issues page