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:: Volume 15, Issue 3 (fall 2017) ::
jmj 2017, 15(3): 49-59 Back to browse issues page
Comparing the Effect of Safranal and Crocin on Serum Levels of Adiponectin, Lipid Profile and Glucose in Healthy and Type One Diabetic Rats
Abstract:   (3365 Views)

Background and Objective: Diabetes is the most common endocrine disease that is associated with impaired glucose and lipid metabolism. Adiponectin is a specific protein secreted from adipose tissue that can affect diabetes progression. Considering the protective effects of crocin, as a potent anti-inflammatory and powerful antioxidant, the aim of this study was to determine the effect of crocin on serum levels of adiponectin, lipid profile and glucose in type one diabetic rat’s model.

Materials and Methods: In this experimental study, 28 wistar male rats were allocated into 4 equal groups. Groups of control, diabetic control and two treated diabetic group with crocin (concentrations of 50 and 100 mg/kg). The diabetes in diabetic control and treated diabetic groups was induced using an intraperitoneal injection of alloxan. Crocin was intraperitoneally injected into treated diabetic groups for 25 days. Saline solution was injected to the animals of control and diabetic control groups. At the end of treatment period, the serum levels of adiponectin, LDL, HDL, triglyceride, total cholesterol and glucose was measured by ELISA.

Results: Compared to diabetic control group, serum levels of LDL, triglycerides, total cholesterol and glucose in diabetic groups treated with 50 and 100 mg/kg of crocin dose-dependent manner decreased, also adiponectin and HDL significantly increased (p<0.05).

Conclusion: Dose dependent administration of crocin by increases adiponectin and decreases blood glucose serum levels, plays a role in regulating lipid metabolism
Keywords: Key words: Diabetes, Crocin, Adiponectin, Lipid profile, Rat
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Type of Study: Research | Subject: Biochemestry
Received: 2017/10/3 | Revised: 2018/06/26 | Accepted: 2018/01/20
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Comparing the Effect of Safranal and Crocin on Serum Levels of Adiponectin, Lipid Profile and Glucose in Healthy and Type One Diabetic Rats . jmj. 2017; 15 (3) :49-59
URL: http://jmj.jums.ac.ir/article-1-1031-en.html

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Volume 15, Issue 3 (fall 2017) Back to browse issues page
فصلنامه دانشگاه علوم پزشکی جهرم Journal of Jahrom University of Medical Sciences
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