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:: Volume 19, Issue 2 (summer 2021) ::
jmj 2021, 19(2): 23-32 Back to browse issues page
The Effect of Kelussia odoratissima Mozaff Extract on SREBP-1C Gene Expression in Fatty Liver Rats and Healthy Rats
Zahra Haghshenas , Noosha Zia-jahromi *
Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
Abstract:   (462 Views)
Background and Aim: Studies have shown that Kelussia lowers low-density lipoprotein levels. Due to the increasing number of patients with fatty liver in this study, we aimed to investigate the effect of Kelussia extract on the expression of SREBP-1C gene in obese mice with fatty liver.
 Materials & Methods: In the present study, 24 rats were divided into four groups: control, negative control, treatment and the second treatment. The two treatment groups received 400 and 800 ml/kg Kelussia extract by gavage, respectively. Rats were anesthetized with chloroform and after dissection, rat liver tissue was collected. Then RNA extraction and cDNA synthesis were performed. Finally, SREBP-1C gene expression was performed using RT-PCR Real time technique and relevant analyzes were performed.
Results: In the present study, the results showed that Kelussia extract at a dose of 800 mg/kg could further reduce the expression of SREBP-1C gene than a dose of 400 mg/kg in rats with fatty liver. It is statistically significant compared to the patient group (p <0.05). The results of biochemical tests confirm liver improvement in treated rats at a dose of 800 mg/kg.
Discussion and Conclusion: It seems that Kelussia extract reduces the expression of SREBP-1C gene due to its orange flavonoid, which plays an important role in the biogenesis of cholesterol, fatty acids and triglycerides. If approved in larger studies, it can be considered as a therapeutic target in fatty liver disease.
Keywords: Kelussia odoratissima Mozaff, SREBP-1C gene, Fatty liver.
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Type of Study: Research | Subject: Biochemestry
Received: 2021/04/9 | Revised: 2021/08/23 | Accepted: 2021/07/10
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Research code: ۹۷۰۱۹۶۳۷۹
Ethics code: IR.IAU.SHK.REC.1399.044


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haghshenas Z, zia-jahromi N. The Effect of Kelussia odoratissima Mozaff Extract on SREBP-1C Gene Expression in Fatty Liver Rats and Healthy Rats. jmj. 2021; 19 (2) :23-32
URL: http://jmj.jums.ac.ir/article-1-1562-en.html


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Volume 19, Issue 2 (summer 2021) Back to browse issues page
فصلنامه دانشگاه علوم پزشکی جهرم Journal of Jahrom University of Medical Sciences
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