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:: Volume 17, Issue 1 (spring 2019) ::
jmj 2019, 17(1): 56-62 Back to browse issues page
The association of beta fibrinogen-455 G/A (rs1800790) gene polymorphism with recurrent abortion in Iranian women
Zeinab Heidari , Mohammad Shokrzadeh , Abbas Mohammadpour
sana non-profit institution
Abstract:   (402 Views)
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Introduction:
Recurrent Abortion is a genetic disorder with different etiologies, as defined by the World Health Organization (WHO), three or more times consecutive pregnancy losses. Genetic anomalies are one of the main etiologies of recurrent abortion. The purpose of the study was to investigate the association between beta fibrinogen (rs1800790) gene polymorphism and recurrent abortion in Iranian women.
Materials and Methods:
In this case-control study, 101 women with recurrent abortion (19-41 years) and 50 women with no history of abortion (23-57 years) (controls) were present. Five milliliters of their blood was collected in EDTA tubes in Imam Khomeini hospital, Sari, Iran, during 2017-2018. Genomic DNA was extracted using salting-out method and genotypic study of polymorphism was performed using PCR-RFLP method. Statistical analysis was performed using Medcalc software version 15.
Results:
Relative frequency of AA, GA, GG genotypes for FGB in patient group were 5.94%, 29.7% and 64.36% and in control group were 2%, 50%, 48% respectively (p= 0.040). The percentage of G and A alleles was 79% and 21% in patient and 73% and 27% in control groups, respectively (p= 0.322). Evidence indicated the AA mutant gene does not increase the risk of recurrent abortion and there is no significant association (p= 0.472). But GA heterozygote relative to GG reference genotype decrease the risk of recurrent abortion (OR= 0.44, 95%CI: 0.22-1.90, P= 0.024).
Conclusion:
The results showed that rs1800790 FGB gene polymorphism did not increase the risk of recurrent abortion.
Keywords: Rs1800790, Recurrent abortion, Beta Fibrinogen- 455 G/A
Full-Text [PDF 679 kb]   (12 Downloads)    
Type of Study: Research | Subject: amozesh pezeshki
Received: 2019/07/28 | Accepted: 2019/09/30 | Published: 2019/09/11
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heidari Z, shokrzadeh M, mohammadpour A. The association of beta fibrinogen-455 G/A (rs1800790) gene polymorphism with recurrent abortion in Iranian women . jmj. 2019; 17 (1) :56-62
URL: http://jmj.jums.ac.ir/article-1-1178-en.html


Volume 17, Issue 1 (spring 2019) Back to browse issues page
فصلنامه دانشگاه علوم پزشکی جهرم Journal of Jahrom University of Medical Sciences
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