[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 9, Number 3 (Fall 2011 2011) ::
jjums 2011, 9(3): 1-7 Back to browse issues page
The inhibitory effects of Walnut (Juglansregia L.) huskhydroalcoholic extract on LDL oxidation in vitro
Hassan Ahmadvand , ali khosrobaigei, Gholamreza Shahsavari, Fovad Abdolahpour, Shahrokh Bagheri, Marzeyeh Rashidi pour
Abstract:   (8001 Views)

Introduction: Oxidation of low-density lipoprotein (LDL) has been strongly implicated in the pathogenesis of atherosclerosis. The use of antioxidant compounds in dietary food stuff including vitamin E and herbal extract such as Walnut (Juglansregia L.) husks hydroalcoholic extract (W) may lead to inhibition of the production of oxidized LDL and may decrease both the development and the progression of atherosclerosis. The present study is an attempt to determine the effects of W on LDL oxidation induced-CuSO4 quantitatively in vitro. Material and Methods: Fasting blood samples were collected from normal people after an overnight fasting and then LDL was isolated. LDL was incubated without CuSO4 as control and with CuSO4 and several concentration of W (0.2, 2 and 20 µg/ml) the formation of conjugated dienes, lag time and Malondialdehyde (MDA)were measured. Inhibition of this Cu-induced oxidation was studied in the presence of several concentrations of W. Results: It was demonstrated that W is able to decrease CuSO4-induced LDL oxidation. Walnut (JuglansregiaL.) huske extract led to an increase rate of 87%, 178% and 202% lag time at concentrations ranging from 0.2µg/ml to 20 µg/ml, respectively. The inhibitory effects of W on LDL oxidation were dose-dependent at concentrations ranging from 0.2 µg/ml to 20 µg/ml. Conclusion: This study showed that W prevented the oxidation of LDL in vitro and it can be concluded that it might have similar effects in vivo.

Keywords: Walnut, LDL, In Vitro
Full-Text [PDF 207 kb]   (842 Downloads)    
Type of Study: Research |
Received: 2013/08/13 | Accepted: 2017/07/22 | Published: 2017/07/22
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ahmadvand H, khosrobaigei A, Shahsavari G, Abdolahpour F, Bagheri S, Rashidi pour M. The inhibitory effects of Walnut (Juglansregia L.) huskhydroalcoholic extract on LDL oxidation in vitro. jjums. 2011; 9 (3) :1-7
URL: http://jmj.jums.ac.ir/article-1-163-en.html
Volume 9, Number 3 (Fall 2011 2011) Back to browse issues page
فصلنامه دانشگاه علوم پزشکی جهرم Journal of Jahrom University of Medical Sciences
Persian site map - English site map - Created in 0.532 seconds with 798 queries by yektaweb 3471