مجله علوم پزشکی پارس

اثر تعاملی 12 هفته فعالیت ورزشی هوازی و مصرف مکمل مولتی ویتامین - مینرال بر میزان سرب خون مردان در مواجهه با هوای آلوده ی شهری

نویسندگان

1 دانشجوی دکتری بیوشیمی و متابولیسم ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی،دانشگاه اصفهان، اصفهان، ایران

2 استاد، گروه فیزیولوژی ورزشی،دانشکده علوم ورزشی،دانشگاه اصفهان، اصفهان، ایران

3 دانشیار، گروه فیزیولوژی ورزشی،دانشکده علوم ورزشی،دانشگاه اصفهان، اصفهان، ایران

4 استاد،دانشکده پزشکی، مرکز تحقیقات رشد و نمو کودکان، دانشگاه علوم پزشکی اصفهان

چکیده

مقدمه: در این مطالعه اثر تعاملی دوازده هفته فعالیت ورزشی هوازی و مصرف مکمل مولتی ویتامین- مینرال بر میزان سرب خون مردان در مواجهه با هوای آلوده شهری مورد بررسی قرار گرفت.
روش کار: در این تحقیق نیمه تجربی، تعداد 46 آزمودنی‌ مرد با میانگین 2.1±25 سال، به صورت داوطلبانه و با رضایت کامل در این مطالعه شرکت و به صورت تصادفی در 4 گروه؛ مکمل و تمرین (11 نفر)- تمرین (11 نفر)– مکمل (12 نفر) و کنترل (12 نفر) قرار گرفتند. فعالیت هوازی با پروتکل تمرینی یکسان و فزاینده برای گروه ترکیبی و تمرین شامل: هفته اول 12 دقیقه دویدن با 60 درصد ضربان قلب ذخیره تا هفته دوازدهم به تدریج به 30 دقیقه دویدن با 85 درصد ضربان قلب ذخیره ای و مصرف مکمل مولتی ویتامین-مینرال به اندازه یک عدد کپسول 500 میلی گرم هر روز برای گروه های ترکیبی و مکمل پژوهش انجام گرفت. متغیر میزان سرب خون یک بار قبل و یک بار بعد از پایان 12 هفته با نمونه گیری خونی سه میلی متر از ورید بازویی با روش طیف سنجی جذب اتمی کوره گرافیتی اندازه گیری شد. از آزمون تحلیل واریانس با اندازه گیری های مکرر برای مقایسه بین گروهی و آزمون تعقیبی LSD برای مقایسه زوج گروه ها استفاده شد. سطح معناداری (0.05>p ) در نظر گرفته شد.
یافته ها: پس از 12 هفته مداخله، کاهش معناداری در میزان غلظت سرب خون در گروه های ترکیبی و مکمل و افزایش معنادار در گروه تمرین در مقایسه با قبل از مطالعه مشاهده شد (0.05>p). نتایج تحلیل واریانس با اندازه گیری تکراری تفاوت معناداری بین گروه ها در میزان غلظت سرب نشان داد، که این تفاوت فقط بین گروه ترکیبی و گروه تمرین معنادار بود.
نتیجه گیری: نتایج پژوهش نشان داد که مصرف مکمل موجب کاهش قابل توجه میزان غلظت سرب هنگام فعالیت ورزشی هوازی در هوای آلوده می شود. بنابراین، پیشنهاد می شود برای کاهش جذب سرب هنگام فعالیت ورزشی هوازی، مواد غذایی حاوی ویتامین ها و املاح مورد نیاز بدن به اندازه مصرف و در صورت کمبود از مکمل های آنتی اکسیدانی استفاده شود.
 

کلیدواژه‌ها

عنوان مقاله [English]

The Interactive effect of 12 weeks of aerobic exercise and the intake of multivitamin minerals supplementation on blood lead levels in the men exposed to urban air pollution

نویسندگان [English]

  • Saber Rezanejad 1
  • Mehdi Kargarfard 2
  • Effat Bambaeichi 3
  • Roya Kelishadi 4

1 PhD Student, Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran

2 Professor, Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran

3 Associate Professor, Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran

4 Professor, School of Medicine, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

چکیده [English]

Introduction: In this study, the interactive effect of 12 weeks of aerobic exercise and the intake of multivitamin-mineral supplementation on blood lead levels in the men exposed to urban air pollution was investigated.
Materials and Methods: In this quasi-experimental study, 46 men with the average age of 25±1.2 year took part voluntarily and with complete satisfaction were randomly assigned to 4 groups: supplement and exercise (N=11), exercise (N=11), supplement (N=12), control (N=12). Aerobic exercise was carried out with the same and increasing practice protocol for the first and second groups (including the first week of 12 minutes running with 60% heart rate up to 12th week, progressively 30 minutes running with 85% heart rate reserve) and with supplementation of multivitamin - minerals (500mg) which were taken as one capsule each day for the first and third groups of the research. The variable including blood lead levels were measured before and after 12 weeks with 3 ml blood sampling from the venous vein by Graphite furnace atomic absorption spectrometry (GFAAS). A repeated measure ANOVA test was used for comparison between groups and the LSD test was used to compare the group pairs. A significant level (P<0.05) was considered.
Results: After 12 weeks of intervention, there was a significant decrease in the concentration of lead in the combined and supplementary groups and a significant increase in the exercise group compared with the pre-study (P<0.05). The results of ANOVA showed a significant difference between the groups in the concentration of lead. This difference was significant between the combined group and the training group, while there was no significant difference between the combined and complementary groups.
Conclusion: The results of this study showed that Consumption of supplementation reduced the concentration of lead when aerobic exercise activity urban polluted air. Therefore, using the same amount of vitamins and necessary minerals is recommended in order to reduce lead absorption during aerobic exercise, and in case of shortage, use antioxidant supplements, such as the multivitamin-mineral supplement.

کلیدواژه‌ها [English]

  • Aerobic Exercise Activity
  • Multivitamin Minerals Supplement
  • Lead
  • Urban Air Pollution
1- Memar Mogaddam M, Dabidi Roshan V. Changes in heat shock protein and superoxide dismutase in pulmonary tissue after regular physical activity and antioxidant feeding. Olympic Journal 2011; 19(4):67-78. (Persian) 2- Ahangari G and et al. Air pollution and health. First Edition. City Publishing. 2015; 11-15. (Persian) 3- Mihaggeg Sh, Hajian M. exercise and air pollution. Journal of the Iranian Medical Society 2011; 31(3): 237-249. (Persian) 4- Kargafard, M. Poursafa, P. Rezanejad, S. Mousavinasab, F. Effects of exercise in polluted air on the aerobic power, serum lactate level and cell blood count of active Individuals, Int J Prev Med 2011; 2(3): 145-150. (Persian) 5- Lippi G, Guidi GC, Maffulli N. Air pollution and sports performance in Beijing. Int J Sports Med 2008; 29(8): 696-8. 6- Rundel KW. Effect of air pollution on athlete health and performance. Br J Sports Med 2012; 20. Bricic I. General population exposure to volatile aromatic hydrocarbons. Arh High Rada Toksikol 2004; 55: 291. 7- Vedal S, Brauer M, White R, Petkau J. Air pollution and daily mortality in a city with low levels of pollution. Environ Health Perspect 2003; 111: 45-51. 8- Blair C, Walls J, Davies NW, Jacobson GA. Volatile organic compounds in runners near a roadway: increased blood levels after short-duration exercise. Br J Sports Med 2010; 44(10): 731. 9- Nel AE. Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the system. The Journal of allergy and clinical immunology. 2008: 102: 539-554. 10- Carlisle AJ, Sharp NC. Exercise and outdoor ambient air pollution. Br J Sports Med 2001; 35: 214-22. 11- Jillian AM, et all. Maternal exposure to metals and persistent pollutants and cord blood immune system biomarkers. Ashley-Martin et al. Environmental Health 2015; 14-52. 12- Gerard H and et al. Long-term air pollution exposure and cardio- respiratory mortality: a review. Hoek et al. Environmental Health 2013; 12-43. 13- Venn AG, Lewis SA, Cooper M, et al. living near a main road and the risk of wheezing illness in children. Am J Rspir Crit Care Med 2001; 164(12): 2117-80. 14- Rodney RD, Jieun L, Irshad H, Michael P. Developmental immune toxicology of lead. Toxicol Appl Pharmacol. 2004; 198(2): 86-94. 15- Boskabady MH, Tabatabai SA, Farkhondeh T. Inhaled lead affects lung pathology and inflammation in sensitized and control guinea pigs. Environ Toxicol. 2014; 107-19. 16- Samarghandian S, Borji A, Afshari R, Delkhosh MB, gholami A. The effect of lead acetate on oxidative stress and antioxidant status in rat broncho alveolar lavage fluid and lung tissue. Toxicol Mech Methods. 2013; 23(6): 432-6. 17- Zorana J A and et al. A study of the combined effects of physical activity and air pollution on mortality in elderly urban residents: The Danish Diet, cancer, and health cohort. Environmental health perspectives 2015; 215-23. 18- Scott W, Marianne H, Mark S G. Exposure to traffic-related air pollution during physical activity and acute changes in blood pressure, autonomic and micro-vascular function in women. Particle and Fiber Toxicology 2014; 11-70. 19- Miguel A. Camelo Rosas. Effect of air pollution on athletes’ performance, health, and mortality. Air & Water Pollution Control Engineering 2013; 5: 11-5. 20- Rodolfo PV and et al. Anti-inflammatory Effects of Aerobic Exercise in Mice Exposed to Air Pollution. Available from: Alessandra Toledo-Arruda Retrieved on 2015; 25-36. 21- Jeremy P and et al. Beneficial cardiovascular effects of reducing exposure to particulate air pollution with a simple facemask. Particle and Fiber Toxicology 2009; 1186-93. 22- Romieu I and et al. Air pollution, oxidative stress and dietary supplementation: a review. Eur Respir J 2008; 31: 179–196. 23- Amir YT, Katherine Ch and Chris C. Modification by antioxidant supplementation of changes in human lung function associated with air pollutant exposure: A systematic review. BMC Public Health 2011; 11:532. 24- Inge B and et al. Physical Activity, Air Pollution and the Brain. Air Quality, Atmosphere & Health Sports Medicine 2014: 44(11) 1505-18. 25- Jamieson J, Taylor C, Weiler H. Marginal zinc deficiency exacerbates bone lead accumulation and high dietary zinc attenuates lead accumulation at the expense of bone density in growing rats. Toxicol Sci. 2006 Jul; 92(1): 286-94. 26- Gaeini A A, Rajabi H. Physical Fitness. Samt publisher. 6 Ed. 2008: 68-69. 27- Carta P, Aru G, Nurchis P, Cadeddu C, Polizzi M, Nieddu V, et al. Study on mortality by specific cause among workers at a lead and zinc foundry in Sardinia. G Ital Med Lav Ergon.2005; 27 (1): 43-5. 28- Kamp F, Donangelo C. Supplementing young women with both zinc and iron protects zinc-related antioxidant indicators previously impaired by iron supplementation. J Nutr. 2008; 138(11): 2186-9. 29- Ahamed M, Siddiqui M K. Environmental lead toxicity and nutritional factors. Clin Nutr. 2007 Aug; 26(4): 400-8. 30- Ashry K M, Sayed Y S, Khamiss R M, Ashmawy I M .Oxidative stress and immunotoxic effects of lead and their amelioration with myrrh. Food Chem Toxicol. 2010 Jan; 48 (1): 236-41.
مجله علوم پزشکی پارس
دوره 17، شماره 1 - شماره پیاپی 47
فروردین 1398
صفحه 25-32