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:: Volume 14, Issue 1 (spring 2016) ::
jmj 2016, 14(1): 45-54 Back to browse issues page
the effects of 3 and 6 weeks of endurance training on stress arising fromdifferent doses of doxorubicin-induced in rats
Valiollah Dabidi Roshan , Shabnam Jamali , Samaneh Afshan
university of mazandaran
Abstract:   (2089 Views)

Introduction: The purpose of this study, the preventive effect of 3 and 6 weeks of aerobic training on HSP72 and CAT liver levels in rats following acute administration of Doxorubicin at doses of 10 or 20 mg per kg. Materials and Methods: The study population consisted of 72 male rats for 60 days to randomly were classified into two groups practice. The exercise groups divided were into groups of 3 and 6 weeks training. At the end of the exercise training group was also randomly into the following groups (10 mg kg dose of doxorubicin and doxorubicin dose of 20 mg per kg and saline) divided were. After 24 hours, the last training session, the specified dose of doxorubicin (10 and 20 mg kg) and saline 0/9 percent were injected as follows. After the biopsy, the ELISA was used to measure levels of HSP72 and CAT liver. Results: A significant increase in HSP72 levels in the Group C / DXR20 compared to C / SAL was seen. Injecting a dose of 20 mg per kg after 3 and 6 weeks of training is a significant increase compared to the CAT (3wEX / SAL) and (6wEX / SAL) was. Conclusion: The use of non-pharmacological methods such as medium-term and short-term resistance exercise before Injecting drug doxorubicin can reduce oxidative stress by increasing the support mechanisms to reduce drug-related liver toxicity and a proactive approach before treatment doxorubicin to be used.

Keywords: HSP72, CAT, Oxidative stress, Doxorubicin
Full-Text [PDF 258 kb]   (616 Downloads)    
Type of Study: Research | Subject: Phiziuology varzeshi
Received: 2016/02/26 | Accepted: 2016/06/20 | Published: 2016/10/5
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Dabidi Roshan V, Jamali S, Afshan S. the effects of 3 and 6 weeks of endurance training on stress arising fromdifferent doses of doxorubicin-induced in rats. jmj. 2016; 14 (1) :45-54
URL: http://jmj.jums.ac.ir/article-1-555-en.html


Volume 14, Issue 1 (spring 2016) Back to browse issues page
فصلنامه دانشگاه علوم پزشکی جهرم Journal of Jahrom University of Medical Sciences
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