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:: Volume 10, Issue 4 (Winter2012 2012) ::
jmj 2012, 10(4): 29-34 Back to browse issues page
The effect of hydroalkoholic extract urtica dioica on concentrations of sex hormones in adult male rats
M Pourahmadi , M Bagheri , H Karimi Jashni , H Kargar Jahromi , S Zarei
Abstract:   (15213 Views)
Introduction: Nowadays using herbal products as an alternative or supplement to contraceptive synthetic drugs is common. There are reports of anti-estrogenic effects of nettle resulting in sterility in mammals. We asked if hydro-alcoholic extract of the nettle root (Urtica diocia) could alter serum concentrations of hormones gandotropins and testosterone, in adult male rats. Materials and Methods: 80 adult male rats were randomly divided into 8 groups of 10. Three groups received 300, 600 and 1000 mg/ kg body weight of hydro-alcoholic extract of nettle root intraperitoneally for 3 days to lethal dose.In remaing groups, one as control, another as sham, and three others received 75, 150, 300 mg/kg body weight for 20 days. The rats were then sacrificed and FSH and LH serum concentrations were determined by ELISA. Results: The nettle extract increased LH significantly (P<0.05), whereas the effect on FSH was variable and nonsignificant. The extract tended to increase testosterone serum concentration but did not reach significant level. Conclusion: Hydro-alcoholic extract of nettle root has a positive effect on LH hormone at the dose of 300 mg/kg body weight.
Keywords: Urtica dioica, Sex Hormones, Rat
Full-Text [PDF 315 kb]   (2103 Downloads)    
Type of Study: Research |
Received: 2013/02/19 | Accepted: 2013/04/29 | Published: 2013/04/29
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Pourahmadi M, Bagheri M, Karimi Jashni H, Kargar Jahromi H, Zarei S. The effect of hydroalkoholic extract urtica dioica on concentrations of sex hormones in adult male rats. jmj. 2012; 10 (4) :29-34
URL: http://jmj.jums.ac.ir/article-1-26-en.html

Volume 10, Issue 4 (Winter2012 2012) Back to browse issues page
فصلنامه دانشگاه علوم پزشکی جهرم Journal of Jahrom University of Medical Sciences
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