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Investigating the distribution of FGB (rs1800790) gene polymorphism in women with recurrent pregnancy loss , refered to the mazandaran university of medical science clinic.
Zeinab Heidari , Mohammad Shokrzadeh , Abbas Mohammadpour
sana non-profit institution
Abstract:   (64 Views)
Background and purpose: recurrent pregnancy loss(RPL) is a heterogeneous disorder with various causes. As defined by the World Health Organization (WHO), spontaneous termination of pregnancy occurs at least three times or more before the 20th week of pregnancy. Anomalies – genetic causes are one of the main causes of RPL. Beta fibrinogen (FGB 455 G/A) gene is one of the effective genes in developing thrombophilia and incidence of RPL.
Materials and Methods: in this case-control study, 101 women with RPL and 50 women with no history of pregnancy loss(controls) were present.5cc of  their peripheral blood was collected in EDTA-containing tubes.genomic DNA was extracted using salting-out method and polymorphism genotype was investigated using PCR-RFLP method.statistical analysis was performed using Medcalc software.
Results: prevalence of GG,GA,AA genotypes for FGB in patient group was 65%,30%,6% and in control group was 48%,50%,2% respectively (p=0/0403).the percentage of allelic frequency of G and A was 79%,21% in patient group and 73%,27% in control group respectively(p=0/3215). evidence indicated that wild homozygotes GG against heterozygote GA with p=0/0242 and GA+AA with p=0/0560 has a protective effect.moreover, heterozygosity against homozygosity indicated double increased the risk of RPL.(OR=2/3667, 1/1757-4/7641) ,95%CI.
Conclusion: the results showed that polymorphism rs1800790 FGB gene is genotypically , passibly related to RPL.
Keywords: rs1800790, FGB, Recurrent pregnancy loss, PCR-RFLP
     
Type of Study: Research | Subject: amozesh pezeshki
Received: 2018/07/28 | Accepted: 2019/02/27
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فصلنامه دانشگاه علوم پزشکی جهرم Journal of Jahrom University of Medical Sciences
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